Publications by authors named "Yuhong Ouyang"
Article Synopsis
- The study aimed to discover new anticoagulant peptides from deep-sea organisms by using various computational methods and to evaluate their effectiveness against FXIa, an enzyme involved in blood clotting.
- Researchers created a database of deep-sea peptides by analyzing the proteins of animals from extreme environments and identified two promising candidates, PRNIF and GNDRCL, which showed strong inhibitory effects on FXIa in lab tests.
- Molecular simulations revealed that PRNIF works as a noncompetitive inhibitor with unique binding characteristics, potentially leading to the development of deep-sea peptides as natural alternatives for preventing blood clots.
Aim: To clarify dynamic changes of IgG subtypes of thyroid peroxidase antibody (TPOAb) during the first postpartum year in Chinese patients diagnosed with postpartum thyroiditis (PPT).
Methods: We retrospectively collected serum samples before and 3, 6, 9 and 12 months postpartum from 58 PPT patients. Levels of TPOAb and its IgG subtypes were examined by ELISA.
The lymphocyte subsets and the percentages of activated T cells or regulatory T cells were observed during the course of postpartum thyroiditis (PPT). Heparin anticoagulant vein bloods were collected at 3, 6, 9 and 12 months postpartum consequently from 27 PPT patients and 23 normal postpartum subjects. Lymphocyte surface antigen CD3, CD4, CD8, HLA-DR and CD25 were stained in appropriate combination and detected with fluorescence-activated cell sorter analysis.
View Article and Find Full Text PDF[Thyroid function and thyroid autoimmunity at the late pregnancy: data from 664 pregnant women].
Zhonghua Fu Chan Ke Za Zhi
August 2006
Objective: To study the prevalence of thyroid diseases, as well as characteristics of the disease spectrum and thyroid autoimmunity in women at the end of pregnancy.
Methods: Six hundred and sixty-four pregnant women (pregnancy group) and 276 non-pregnant women (control group) were enrolled in the study. Serum thyrotropin (TSH), thyroid peroxidase antibody (TPOAb), free T(3) (FT(3)) and free T(4) (FT(4)) were measured by high-sensitive immunochemiluminescent assay, and urinary iodine was also examined at the end of pregnancy.
[The dynamic changes of serum Th1 and Th2 cytokines in postpartum thyroiditis].
Zhonghua Nei Ke Za Zhi
June 2006
Objective: To investigate the dynamic changes of serum Th1 and Th2 cytokines in patients with postpartum thyroiditis (PPT) during the first postpartum year.
Methods: 21 patients diagnosed as clinical PPT and 11 healthy postpartum women were enrolled in the study. Blood samples were taken before delivery and every 3 months postpartum for testing serum IFNgamma, IL-2, IL-4 and IL-10, which were measured with ELISA method.