Health system delay and risk factors in pulmonary tuberculosis diagnosis before and during the COVID-19 epidemic: a multi-center survey in China.

Background: Understanding health system delay (HSD) in pulmonary tuberculosis (PTB) diagnosis aids in tailoring interventions for case detection and curbing transmission. However, recent nationwide studies on HSD in PTB diagnosis have been scarce. This study assesses HSD and its risk factors in China, taking into account the impact of the COVID-19 epidemic.

Endolysins as Effective Agents for Decontaminating , , and on Mung Bean Seeds.

Seeds are a major source of contamination by foodborne pathogens such as , , and , significantly increasing the risk of foodborne diseases associated with fresh produce like sprouts. In this study, we described novel endolysins and the engineered variants that exhibited potent bactericidal activity against these pathogens. These endolysins demonstrated strong bactericidal effects independently of outer membrane permeabilizers, effectively killing , , and to undetectable levels (>4-log kill) at concentrations as low as 12.

Meter-Scale Wearable Multifunctional Core-Shell Nanofiber Textiles for Ultra-Broadband Electromagnetic Interference Shielding and Infrared Stealth.

The rapid development of wireless communication and infrared (IR) detection technologies has generated an increasing demand for large-size high-performance wearable electromagnetic interference (EMI) shielding and IR stealth textiles. Herein, meter-scale MXene/graphene oxide (MG)@monstera nanocellulose (MC) core-shell nanofiber textiles are fabricated for the first time using a multi-stage cryogenic drying-assisted coaxial wet spinning assembly strategy, with MG as the conductive composite core and MC as the organic skeleton shell. The highly aligned shell and dense core endow the nanofibers with a great toughness of ≈39.

Tectonic Characteristics of the Juyanhai Depression in the Yingen-Ejinaqi Basin, Inner Mongolia, China, Based on Gravity, Electrical, and Seismic Data.

To determine the tectonic characteristics of the Juyanhai Depression in the west of the Yingen-Ejinaqi Basin, gravity data in the study area were processed and analyzed on the basis of the collection of existing geophysical data. Then, fault systems in the Juyanhai Depression were comprehensively presumed and explained mainly using processed gravity data in conjunction with the electrical and seismic data. Existing tectonic units in the depression were divided and studied afterward.

Identification of the enzymatic cleavage relationship between anti-aging protein α-Klotho and Alzheimer's disease biomarker BACE1.

Background: The α-Klotho is known to be involved in longevity and various age-related diseases, including cognitive impairment. BACE1, an important enzyme associated with the pathological process of Alzheimer's disease (AD), serves as a biomarker for predicting changes in cognitive function. Although both proteins are closely linked to age-related cognitive function, the mechanism of their interaction remains unclear.

PTP-3 regulated by VB12 is important for ageing health in C. elegans.

Ageing is associated with cognitive decline, which is a significant factor in the development of dementia. Vitamin B12 (VB12) is crucial for maintaining proper nervous system function, as well as for protein, fat, and carbohydrate metabolism, and DNA synthesis. Moreover, it helps prevent serious health conditions such as pernicious anemia, neurodegenerative diseases, and Alzheimer's disease.

Sanye tablet regulates gut microbiota and bile acid metabolism to attenuate hepatic steatosis.

Ethnopharmacological Relevance: Sanye Tablet (SYT), a patent traditional Chinese prescription, is commonly used in treating type 2 diabetes mellitus and hyperlipidemia. Both clinical and animal studies suggest that SYT effectively regulates lipid metabolism. However, its mode of action on hepatic steatosis has yet to be fully elucidated.

First-in-human phase 1 study of an orally bioavailable vascular-disrupting agent DX1002 in patients with advanced solid tumors.

DX1002 is an oral vascular-disrupting agent and exhibits promising results in preclinical studies, leading to tumor vasculature destruction and xenografted tumor necrosis in various animal models. In the phase 1 trial, 17 patients with solid tumors receive DX1002 ranging from 50 to 1,100 mg. The maximum tolerated dose and recommended phase 2 dose of DX1002 are determined as 600 mg once daily.

Integration of radiomic and deep features to reliably differentiate benign renal lesions from renal cell carcinoma.

Purpose: Accurate differentiation of benign renal lesions from renal cell carcinoma (RCC) is crucial for optimized management, particularly for small renal lesions (≤4 cm in diameter). This study aimed to integrate clinical data, radiomic features, and deep features to improve diagnostic performance in distinguishing benign renal lesions from RCC.

Methods: In this retrospective study, radiomic and deep scores were constructed using the AutoGluon-Tabular classifier based on radiomic and deep features extracted from the whole region of CT imaging.

Rib suppression-based radiomics for diagnosis of neonatal respiratory distress syndrome in chest X-rays.

This study aims to refine a radiomics-based diagnostic approach for detecting neonatal respiratory distress syndrome (NRDS) and examines the influence of rib suppression on the diagnostic precision of radiomics models using neonatal chest X-ray (CXR) images. A total of 138 CXR images were collected in this study. The data was partitioned into training and validation subsets based on chronological order.

Giant energy storage density with ultrahigh efficiency in multilayer ceramic capacitors via interlaminar strain engineering.

Dielectric capacitors with high energy storage performance are highly desired for advanced power electronic devices and systems. Even though strenuous efforts have been dedicated to closing the gap of energy storage density between the dielectric capacitors and the electrochemical capacitors/batteries, a single-minded pursuit of high energy density without a near-zero energy loss for ultrahigh energy efficiency as the grantee is in vain. Herein, for the purpose of decoupling the inherent conflicts between high polarization and low electric hysteresis (loss), and achieving high energy storage density and efficiency simultaneously in multilayer ceramic capacitors (MLCCs), we propose an interlaminar strain engineering strategy to modulate the domain structure and manipulate the polarization behavior of the dielectric mediums.

Erratum: Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression: Erratum.

[This corrects the article DOI: 10.7150/thno.20942.

Association between ABCB4 variants and intrahepatic cholestasis of pregnancy.

The ABCB4 gene encodes multidrug resistance protein 3(MDR3), which is a phosphatidylcholine(PC) transfer enzyme that transfers lecithin from the inner part of the phospholipid bilayer to the extracellular bile. The occurrence of intrahepatic cholestasis of pregnancy(ICP) is closely related to ABCB4 variants, but there is limited research on this topic in southern Anhui, China. We sequenced ABCB4 in pregnant women with ICP and healthy pregnant women to explore the relationship.

Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway.

Plants, algae and photosynthetic bacteria convert light into chemical energy by means of photosynthesis, thus providing food and energy for most organisms on Earth. Photosynthetic pigments, including chlorophylls (Chls) and carotenoids, are essential components that absorb the light energy necessary to drive electron transport in photosynthesis. The biosynthesis of Chl shares several steps in common with the biosynthesis of other tetrapyrroles, including siroheme, heme and phycobilins.

Intercellular communication is crucial in the regulation of healthy aging via exosomes.

The hallmarks of aging encompass a variety of molecular categories (genomic, telomeric, and epigenetic), organelles (proteostasis, autophagy, and mitochondria), cellular components (including stem cells), systems (such as intercellular communication and chronic inflammation), and environmental factors (dysbiosis and nutrient sensing). These hallmarks play a crucial role in the aging process. Despite their intricate interconnections, the relationships among the hallmarks of aging remain unclear.

Assessment of public literacy in TB prevention and control in the National 13th Five-Year plan for Tuberculosis Prevention and Control (2016-2020) in China.

Background: China has always been a country with a high burden of tuberculosis. In order to end TB, the Chinese government launched three plans for TB prevention and control. The Chinese government implemented the National 13th Five-Year plan for Tuberculosis Prevention and Control (2016-2020) to promote TB prevention and control from policy, technology, health promotion and other aspects from 2016 to 2020.

Heterophilous distribution propagation for Graph Neural Networks.

Graph Neural Networks (GNNs) have achieved remarkable success in various graph mining tasks by aggregating information from neighborhoods for representation learning. The success relies on the homophily assumption that nearby nodes exhibit similar behaviors, while it may be violated in many real-world graphs. Recently, heterophilous graph neural networks (HeterGNNs) have attracted increasing attention by modifying the neural message passing schema for heterophilous neighborhoods.

A Review on MXene/Nanocellulose Composites: Toward Wearable Multifunctional Electromagnetic Interference Shielding Application.

With the rapid development of mobile communication technology and wearable electronic devices, the electromagnetic radiation generated by high-frequency information exchange inevitably threatens human health, so high-performance wearable electromagnetic interference (EMI) shielding materials are urgently needed. The 2D nanomaterial MXene exhibits superior EMI shielding performance owing to its high conductivity, however, its mechanical properties are limited due to the high porosity between MXene nanosheets. In recent years, it has been reported that by introducing natural nanocellulose as an organic framework, the EMI shielding and mechanical properties of MXene/nanocellulose composites can be synergically improved, which are expected to be widely used in wearable multifunctional shielding devices.

Comprehensive Mendelian Randomization Analysis of Smoking and Its Effects on Venous Thromboembolism.

An increasing number of Mendelian randomization (MR) studies have evaluated the causal link between smoking and venous thromboembolism (VTE). However, previous studies often rely on single genetic variants related to smoking quantity and exhibit various other shortcomings, making them prone to pleiotropy and potentially leading to imprecise causal estimates. Thus, the deeper causal mechanisms remain largely unexplored.

Analysis of linear accelerator-based fractionated stereotactic radiotherapy in brain metastases: efficacy, safety, and dose tolerances.

Objective: To assess the efficacy and safety of linear accelerator-based fractionated stereotactic radiotherapy (LINAC-FSRT) in patients with brain metastases (BM).

Methods: We retrospectively analyzed 214 patients treated with LINAC-FSRT, categorized based on biologically effective dose (BED10, / = 10) into two groups (≤55 Gy, >55 Gy). Stratified analyses were conducted based on targeted therapy to compare survival outcomes.

Percutaneous hepatic artery infusion chemotherapy with oxaliplatin and fluoropyrimidines in treatment-resistant colorectal cancer patients with unresectable liver metastases: a retrospective cohort study.

Background: Subsequent lines of therapy for chemotherapy-resistant metastatic colorectal cancer (CRC) have shown limited efficacy. Herein, we retrospectively investigated the efficacy and safety of hepatic artery infusion chemotherapy (HAIC) using oxaliplatin plus 5-FU/FUDR in patients with unresectable colorectal liver metastases (CRLM) who progressed following standard chemotherapy regimens.

Methods: From March 2017 to April 2023, CRC patients with unresectable CRLM who progressed following standard chemotherapy and subsequently received HAIC oxaliplatin plus 5-FU/FUDR were evaluated.

Higher Dietary Inflammatory Index Score Is Associated With a Greater Risk of High Allostatic Load in US Adults: National Health and Nutrition Examination Survey, 2017-2020.

Background: Allostatic load (AL) is a comprehensive indicator of chronic stress. Foods with pro-inflammatory properties can increase the risk of elevated AL levels. However, no studies have explored the association between AL and dietary inflammation.

The Mediating Role of Psychological Resilience in Chinese Nursing Students' Professional Identity and Learning Burnout.

Purpose: This study investigated whether professional identity predicts learning burnout among Chinese nursing students, and whether resilience moderates this relationship.

Methods: This cross-sectional study recruited 635 students from a nursing college at a medical university in Hefei, China. Data were collected using the professional identity questionnaire, learning burnout scale for college students, and 10-item Connor-Davidson Resilience Scale.

Construction of a prognostic model based on cuproptosis-related genes and exploration of the value of DLAT and DLST in the metastasis for non-small cell lung cancer.

Background: To reveal the clinical value of cuproptosis-related genes on prognosis and metastasis in non-small cell lung cancer.

Methods: Gene expression profiles and clinical information of non-small cell lung cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The data were grouped into training set, internal testing set, and external testing set.