Publications by authors named "Yuhong Chen"

Background: Primary angle-closure glaucoma (PACG) is a leading cause of irreversible blindness worldwide. However, the features of the morphology of Schlemm's canal (SC) in PACG eyes after phacoemulsification with goniosynechialysis (phaco-GSL) surgery are still unknown. This study aimed to evaluate changes in the SC in Chinese patients with PACG after phaco-GSL using swept-source optical coherence tomography (SS-OCT).

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Background: Anterior segment dysgenesis (ASD) encompasses a range of congenital disorders affecting the development of the eye's anterior segment, often leading to significant visual impairment and glaucoma. Although numerous studies have focused on the genetic basis of ASD, few have comprehensively compared the clinical features across ASD subtypes. This study aims to address this gap by describing and comparing the clinical characteristics and ultrasound biomicroscopy (UBM) imaging features of various ASD subtypes in a Chinese tertiary medical center.

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The identification of ferroptosis-sensitive cancers is critical for the application of ferroptosis-inducing therapies in cancer therapy. Here, patient-derived organoid screening models of colorectal cancer are established to identify tumors that are sensitive to ferroptosis-inducing therapy. This study discovers that patient-derived tumors characterized by mitophagy deficiency are hypersensitive to ferroptosis-inducing therapies.

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The hydrogen storage properties of the 2D carbon allotrope Irida-graphene (IG) were investigated using first-principles calculation. The intrinsic IG adsorption energy for H is only -0.06 eV, significantly lower than the effective adsorption threshold.

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Recently, heterogeneous graphs have attracted widespread attention as a powerful and practical superclass of traditional homogeneous graphs, which reflect the multi-type node entities and edge relations in the real world. Most existing methods adopt meta-path construction as the mainstream to learn long-range heterogeneous semantic messages between nodes. However, such schema constructs the node-wise correlation by connecting nodes via pre-computed fixed paths, which neglects the diversities of meta-paths on the path type and path range.

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Background: Based on real data from the FDA Adverse Event Reporting System (FAERS), we explored and evaluated the adverse reactions (ADRs) of sulfasalazine (SSZ) in the first quarter of 2004-2023 to provide a reference basis and early warning for the safe use of SSZ in the clinic.

Research Design And Methods: The reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the empirical Bayesian geometric mean (EBGM) were used as measures of SSZ-associated adverse events (AEs) signals, mining for potential positive signals between SSZ and AE.

Results: In this study, a total of 5327 case reports related to SSZ in the last 20 years involving 25 system organ classes (SOCs) were collected in FAERS.

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Background: Sex differences in blood pressure (BP) levels and hypertension are important and the role of socioeconomic status (SES) in sex differences in hypertension remains unclear.

Objective: This study aimed to evaluate the impact of SES on sex differences of hypertension in a nationally representative survey study.

Methods: A total of 98,658 participants aged ≥18 years who have lived in their current residence for ≥6 months were recruited from 162 study sites across mainland China.

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Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy and the only curable therapy is allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, allo-HSCT is not appropriate for all CMML patients, and relapse is the leading cause of treatment failure. This project conducted a nationwide multicenter real-world study to develop a novel prediction scoring system for early relapse.

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Background: Cancer-associated fibroblasts (CAFs) play a pivotal role in shaping the microenvironment of hepatocellular carcinoma (HCC). However, the mechanisms through which CAFs influence the progression of HCC remain incompletely understood.

Methods: Single-cell RNA sequencing datasets (GSE158723 and GSE112271) were retrieved from the Gene Expression Omnibus (GEO) database at the National Center for Biotechnology Information (NCBI) and analyzed using R software.

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Background: Effective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear.

Methods: We enrolled patients 50 years of age or older with type 2 diabetes, elevated systolic blood pressure, and an increased risk of cardiovascular disease at 145 clinical sites across China. Patients were randomly assigned to receive intensive treatment that targeted a systolic blood pressure of less than 120 mm Hg or standard treatment that targeted a systolic blood pressure of less than 140 mm Hg for up to 5 years.

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RIF1 (RAP1 interacting factor) fulfills diverse roles in DNA double-strand break repair, DNA replication, and nuclear organization. RIF1 is expressed as two splice variants, RIF1-Long (RIF1-L) and RIF1-Short (RIF1-S), from the alternative splicing (AS) of Exon 32 (Ex32) which encodes a 26 aa Ser/Lys-rich cassette peptide in the RIF1 C-terminal domain (CTD). Here we demonstrate that Ex32 inclusion was repressed by DNA damage and oncogenesis but peaked at G/M phase of the cell cycle.

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We aimed to prospectively explore the risk factors for measurable residual disease (MRD) positivity after allogeneic stem cell transplantation (allo-SCT) in AML patients (n = 478). The cumulative incidences (CIs) of post-SCT MRD positivity at 100 days, 360 days and 3 years were 4.6%, 12.

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Objective: We aimed to compare the quality-adjusted time without symptoms or toxicity (Q-TWiST) in acute myeloid leukemia (AML) patients who received haploidentical-related donor (HID) and identical sibling donor (ISD) hematopoietic stem cell transplantation (HSCT).

Methods: Five clinical health states were defined: toxicity (TOX), acute graft-versus-host disease (GVHD), chronic GVHD (cGVHD), time without symptoms and toxicity (TWiST) and relapse (REL). The equation used in this study was as follows: Q-TWiST= × TOX + × TWiST + × REL + × aGVHD + × cGVHD.

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Creating multi-level digital-twin models for mechanical ventilation requires a detailed estimation of regional lung volume. An accurate generic map between 2D chest surface motion and 3D regional lung volume could provide improved regionalisation and clinically acceptable estimates localising lung damage. This work investigates the relationship between CT lung volumes and the forced vital capacity (FVC) a surrogate of tidal volume proven linked to 2D chest motion.

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Immunity has shown potentials in informing drug development for cardiometabolic diseases, such as type 2 diabetes (T2D) and coronary artery disease (CAD). Here, we performed a transcriptome-wide Mendelian randomization (MR) study to estimate the putative causal effects of 11,021 gene expression profiles during CD4 T cells activation on the development of T2D and CAD. Robust MR and colocalization evidence was observed for 162 genes altering T2D risk and 80 genes altering CAD risk, with 12% and 16% respectively demonstrating CD4 T cell specificity.

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Article Synopsis
  • Congenital aniridia is a rare eye condition leading to iris absence, which often results in serious complications like blindness and glaucoma.
  • A study of 60 patients in China identified genetic mutations, mostly in the PAX6 gene, using advanced genetic analysis methods that revealed a 98.3% mutation detection rate.
  • The findings highlight the genetic diversity of aniridia within families and emphasize the importance of understanding these mutations for potential therapeutic approaches.
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  • HF1 is a newly isolated probiotic strain that produces various antimicrobial lipopeptides effective against plant fungi and beneficial for broiler growth.
  • The strain showcased significant inhibitory effects on 20 species of plant fungi and promoted broiler weight gain by 15.84%.
  • Analysis revealed that HF1 generates multiple homologs of surfactin and fengycin, indicating its potential as a biocontrol agent for plant diseases and a feed additive for sustainable agriculture.
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() is a main cause of hospital-acquired fungal infections. Combination therapy is promising as a novel anti- strategy because of its better efficacy. Theasaponins are pentacyclic triterpenes in the genus with multiple biological activities.

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  • A new definition of cardiovascular health (CVH) was created to assess heart health more effectively, particularly in patients with high blood sugar (hyperglycemia).
  • In a study of 5,225 participants, those with lower CVH scores were at a higher risk for subclinical atherosclerosis, a condition that can lead to heart problems.
  • Improvements in CVH over time were linked to lower risks of subclinical atherosclerosis, suggesting that enhancing heart health metrics can mitigate risks associated with hyperglycemia.
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Background: Glaucoma is a leading cause of vision impairment and permanent blindness. Primary open-angle glaucoma (POAG) is a prominent type of primary glaucoma; however, its cause is difficult to determine. This study aimed to analyze the serum lipid profile of Chinese POAG patients and assess its correlation with intraocular pressure (IOP).

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  • A phase II trial was conducted to test the efficacy of a high-dose decitabine treatment (MegaDAC) for patients with relapsed/refractory acute myeloid leukemia (R/R AML) who did not respond to other targeted therapies, enrolling 70 patients from 2019 to 2023.
  • Despite previous treatments, all patients who underwent MegaDAC after allogeneic hematopoietic cell transplantation (allo-HCT) achieved minimal residual disease (MRD) negativity, showing a significant reduction in genetic abnormalities without major toxicity.
  • The results indicate promising long-term outcomes for patients, with a 2-year cumulative incidence of relapse of 29.6% and overall survival rate of 58.6%, suggesting
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Article Synopsis
  • - The study focused on analyzing changes in lysine-specific methyltransferase 2A partial tandem duplications (-PTD) in AML patients before and after receiving haploidentical donor hematopoietic stem cell transplantation (HID HSCT).
  • - Among 64 AML patients, those with pre-HSCT -PTD levels ≥1% experienced a slower decrease in -PTD levels post-transplant and had a significantly higher risk of relapse at 2 years compared to those with levels <1%.
  • - Pre-transplant -PTD levels ≥1% were identified as an independent risk factor for relapse, highlighting its potential as a predictive marker for patient outcomes following HID HSCT.
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Article Synopsis
  • The study investigates how socioeconomic status (SES) affects blood pressure (BP) and hypertension differences between men and women using data from a large survey in China.
  • Findings reveal that men generally have higher BP and hypertension prevalence than women, but this gap narrows in women who experience better SES, as they show lower BP levels and hypertension rates.
  • The results suggest that public health policies should be tailored to address these sex-specific disparities and socioeconomic inequalities in hypertension management.
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  • Observational studies suggest that SGLT2 inhibitors may contribute to healthier aging, but their specific effects on brain-related traits are unclear.
  • Using Mendelian randomization, the researchers examined how SGLT2 inhibition impacts chronological age, biological age, and cognitive abilities, with brain imaging-derived phenotypes acting as potential mediators.
  • Results indicate that SGLT2 inhibition is linked to increased father’s longevity, better cognitive function, and higher intelligence, with certain brain imaging traits identified as mediators in these relationships.
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