Publications by authors named "Yuhe Ren"
Cell Biosci
December 2022
Article Synopsis
- ADD1 and TPX2 are important centrosomal proteins that regulate the assembly of the meiotic spindle in mouse oocytes, which is crucial for accurate chromosome segregation during cell division.
- Taxol treatment stabilizes microtubules and enhances the localization of ADD1 and TPX2 proteins in the spindle formation, while a knockdown of ADD1 leads to chromosomal misalignment and increased aneuploidy.
- TPX2 influences the activity of ADD1 by affecting its phosphorylation, which is essential for proper spindle assembly and the prevention of oocyte arrest during meiosis.
