Publications by authors named "Yuhe Cheng"
Article Synopsis
- - Tobacco use is linked to various cancers and causes about 25% of cancer-related deaths, primarily due to harmful substances in tobacco smoke, including tobacco-specific nitrosamines like NNN and NNK that create damaging DNA adducts.
- - The study identified new mutational patterns induced by these DNA adducts, particularly in certain cancer cell lines and rat tumors, indicating specific mutations that occur in the DNA from exposure to these harmful compounds.
- - Analyzing 2,780 cancer genomes revealed that these mutational patterns were present in around 180 tumors from types of cancer not typically associated with smoking, suggesting that the damage caused by the POB pathway could play a unique role in various cancers, including hematological
A typical naturally occurring disulfide structure in proteins is an 8-membered disulfide ring formed between two adjacent cysteine (Cys-Cys) residues. Based on this structure, we designed 7- to 9-membered disulfide ring molecules, embedded in the 7-azabicyclo[2.2.
View Article and Find Full Text PDFMosaic variants (MVs) reflect mutagenic processes during embryonic development and environmental exposure, accumulate with aging and underlie diseases such as cancer and autism. The detection of noncancer MVs has been computationally challenging due to the sparse representation of nonclonally expanded MVs. Here we present DeepMosaic, combining an image-based visualization module for single nucleotide MVs and a convolutional neural network-based classification module for control-independent MV detection.
View Article and Find Full Text PDFBackground: Metabolic reprogramming is a hallmark of cancer. However, the roles of long noncoding RNAs (lncRNAs) in cancer metabolism, especially glucose metabolism remain largely unknown.
Results: In this study, we identified and functionally characterized a novel metabolism-related lncRNA, LINC00930, which was upregulated and associated with tumorigenesis, lymphatic invasion, metastasis, and poor prognosis in nasopharyngeal carcinoma (NPC).
Objective: To investigate the effect of inner-heating acupuncture on apoptosis of chondrocytes and expression of Caspase-3 and Caspase-9 in rats with knee osteoarthritis (KOA).
Methods: A total of 32 rats were divided into a normal group, a model group, a control treatment group and a treatment group by random number grouping method, 8 rats in each one. The rats in the normal group received no intervention.
Objective: To observe the influence of electroacupuncture (EA) of "Fengfu" (GV16) and "Taichong" (LR3) on morphological changes and apoptotic percentage of substantia nigra cells so as to explore its underlying mechanism in relieving Parkinson's disease.
Methods: Forty Wistar rats were randomly divided into normal control, sham-operation (sham), model and EA groups, with 10 rats in each. The Parkinson's disease model was established by micro-injection of 6-hydroxyl-dopamine (6-OHDA) into the right striatum.
Objective: To explore the mechanism of electroacupuncture therapy on Parkinson's disease (PD).
Methods: Fifty Wistar rats were randomly divided into a normal group, a sham-operation group, a model group, a Fengfu-Taichong group and a Shuanggu Yitong group. PD model was duplicated by microinjection of 6-Hydroxyl-Dopamine into right corpora striata, and by microinjection of normal saline in sham-operation group.