Imidazoline derivatives are widely used to prevent corrosion due to their toxicity and mitigation potential. The present study deals with the synthesis of two imidazole Schiff derivatives (JSMP and JSPP) based on imidazole hexanoate (JSMZ). The corrosion mitigation potential and mechanism in 1.
View Article and Find Full Text PDFAim: This study aimed to investigate the role of discoidin domain receptor tyrosine kinase 1 (DDR1) in liver hepatocellular carcinoma (LIHC) and to evaluate its prognostic value on patient response to combination therapy.
Methods: In the current retrospective study, we examined the protein expression of DDR1 in various cancers by standard immunohistochemical (IHC) methods and evaluated its clinical significance in LIHC personalized treatment. Multiple online databases, including The Cancer Genome Atlas (TCGA), TIMER, GEO, ROC Plotter, and Genomics of Drug Sensitivity in Cancer (GDSC), were used.
Chitosan samples were prepared from the shells of marine animals (crab and shrimp) and the cell walls of fungi (agaricus bisporus and aspergillus niger). Fourier-transform infrared spectroscopy (FT-IR) was used to detect their molecular structures, while headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) was employed to analyze their odor composition. A total of 220 volatile organic compounds (VOCs), including esters, ketones, aldehydes, etc.
View Article and Find Full Text PDFGlycosylated polyene macrolides are important antifungal agents that are produced by many actinomycete species. Development of new polyenes may deliver improved antibiotics. Here, was genetically re-programmed to synthesise pentaene analogues of the heptaene amphotericin B.
View Article and Find Full Text PDFActivation of a silent gene cluster in leads to synthesis of a cinnamoyl-containing non-ribosomal peptide (CCNP) that is related to skyllamycins. This novel CCNP was isolated and its structure was interrogated using mass spectrometry and nuclear magnetic resonance spectroscopy. The isolated compound is an oxidised skyllamycin A in which an additional oxygen atom is incorporated in the cinnamoyl side-chain in the form of an epoxide.
View Article and Find Full Text PDFOcean acidification (OA) driven by elevated carbon dioxide (CO) levels is expected to disturb marine ecological processes, including the formation and control of harmful algal blooms (HABs). In this study, the effects of rising CO on the allelopathic effects of macroalgae Ulva pertusa to a toxic dinoflagellate Karenia mikimotoi were investigated. It was found that high level of CO (1000 ppmv) promoted the competitive growth of K.
View Article and Find Full Text PDFBackground: Deer tuberculosis is a chronic zoonotic infectious disease, despite the existence of socio-economic and zoonotic risk factors, but at present, there has been no systematic review of deer tuberculosis prevalence in mainland China. The aim of this meta-analysis was to estimate the overall prevalence of deer TB in mainland China and to assess possible associations between potential risk factors and the prevalence of deer tuberculosis.
Methodology: This study was searched in six databases in Chinese and English, respectively (1981 to December 2023).
Mycobacterium tuberculosis is a pathogenic bacterium that is parasitic in macrophages and show high adaptation to the host's immune response. It can also trigger a complex immune response in the host. This relies on proteins encoded by a series of M.
View Article and Find Full Text PDFCyanobacterial blooms caused by eutrophication have become a major environmental problem in aquatic ecosystems worldwide over the last few decades. Phosphorus is a limiting nutrient that affects the growth of cyanobacteria and plays a role in dynamic changes in algal density and the formation of cyanobacterial blooms. Therefore, identifying the association between phosphorus sources and Microcystis, which is the most representative and harmful cyanobacteria, is essential for building an understanding of the ecological risks of cyanobacterial blooms.
View Article and Find Full Text PDFPreviously, we researched that bovine viral diarrhea virus (BVDV) induced a very significant increase in fibroblast growth factor 21 (FGF21) expression in mouse liver and that FGF21 was increased in the peripheral blood of BVD cattle and BVD mice. To determine the role of FGF21 in relieving clinical symptoms and inhibiting the intestinal damage caused by BVDV in BVD development in mice, BALB/c mice were intraperitoneally injected with cytopathic biotype (cp) BVDV-LS01 (isolated and identified by our group) to establish a BVD mouse model. The role of FGF21 in the BVD mouse model was investigated by injecting the mice with FGF21.
View Article and Find Full Text PDFCarbon-based all-inorganic perovskite solar cells (C-IPSCs) are stable, upscalable and have low CO-footprint to fabricate. However, they are inefficient in converting light to electricity due to poor hole extraction at perovskite/carbon interface. Here we enable an efficient hole extraction in C-IPSCs with the aid of inorganic p-type nickel oxide nanoparticles (NiO-NPs) at the interface and in carbon.
View Article and Find Full Text PDFLinoleic acid (LA) shows great potential in inhibiting the growth of multiple red tide microalgae by disturbing algal physio-biochemical processes. However, our knowledge on the mechanisms of algal mortality at metabolic level remains limited. Herein, the response of K.
View Article and Find Full Text PDFAntibiotic resistance genes (ARGs) have caused widespread concern because of their potential harm to environmental safety and human health. As substitutes for conventional plastics, the toxic effects of short-term degradation products of biodegradable plastics (polylactic acid (PLA) and polyhydroxyalkanoates (PHA)) on bacteria and their impact on ARGs transfer were the focus of this study. After 60 days of degradation, more secondary nanoplastics were released from the biodegradable plastics PLA and PHA than that from the conventional plastics polystyrene (PS).
View Article and Find Full Text PDFExtracellular polymeric substances (EPS) are important shields for microalgae when confronting with external stresses. However, the underlying roles of EPS in the interactions between microplastics (MPs) and microalgae remain poorly understood. In this study, three sizes of polystyrene (PS) MPs (20 nm, 100 nm, and 1 μm) were chosen for evaluating the compositions of EPS, secreted by Microcystis aeruginosa during exposure.
View Article and Find Full Text PDFIn this study, the SNP-TiO@Cu-MOF composite was prepared successfully by loading non-noble metal modified TiO (SNP-TiO) on the surface of copper metal organic skeleton (Cu-MOF), and compared the inactivation efficiency of different photocatalysts to Karenia mikimotoi (K. mikimotoi) under visible light. The obtained photocatalyst had the characteristic crystal faces of Cu-MOF and SNP- TiO, and contained functional groups such as Cu-O, -COOH, N-O, P-O, etc.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2023
Acidification of seawater resulting from absorption of excessive carbon dioxide from the atmosphere is posing a serious threat to marine ecosystem. In this study, we hypothesized that acidified seawater attenuates allelopathic effects of macroalgae on red tide algae because the increase of dissolved carbon dioxide benefits algal growth, and investigated the allelopathic effects of Ulva pertusa on Karenia mikimotoi in response to seawater acidification by determining cell density, photosynthetic pigment content, chlorophyll fluorescence parameters, and chloroplast structure of K. mikimotoi under U.
View Article and Find Full Text PDFThe accumulation of reducing sugars in cold-stored tubers, known as cold-induced sweetening (CIS), negatively affects potato processing quality. The starch to sugar interconversion pathways that are altered in cold-stored CIS tubers have been elucidated, but the mechanism that regulates them remains largely unknown. This study identified a CBF/DREB transcription factor (StTINY3) that enhances CIS resistance by both activating starch biosynthesis and repressing the hydrolysis of sucrose to reducing sugars in detached cold-stored tubers.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
October 2022
In this study, cationic polyacrylamide (CPAM)-modified diatomite and cetyl trimethyl ammonium bromide (CTAB)-modified diatomite were synthesized and used as conditioners for sewage sludge dewatering. The effects of these two types of modified diatomite on the dewaterability and settling performance of the activated sludge were studied. The mechanisms of the two modified diatomite types in the activated sludge system were elucidated.
View Article and Find Full Text PDFTriphenyl phosphate (TPHP) is a kind of organophosphorus flame retardants, and its use is increasing annually. However, the toxic effect associated with exposure to it has not been adequately investigated. Therefore, in this study, we determined the toxic dose of TPHP in the economic fish species, Cyprinus carpio.
View Article and Find Full Text PDFAntibiotics (Basel)
March 2022
Glycosylated polyene macrolides include effective antifungal agents, such as pimaricin, nystatin, candicidin, and amphotericin B. For the treatment of systemic mycoses, amphotericin B has been described as a gold-standard antibiotic because of its potent activity against a broad spectrum of fungal pathogens, which do not readily become resistant. However, amphotericin B has severe toxic side effects, and the development of safer alternatives remains an important objective.
View Article and Find Full Text PDFIn this study, we report the biodiversity and functional characteristics of microplastic-attached biofilms originating from two freshwater bacterial communities. Even though the microplastic-biofilm (MPB) diversities are mostly determined by original bacteria instead of microplastic types, the results from 16S rRNA amplicon sequencing still showed that the dynamic biofilm successions on different microplastics were highly dissimilar. Furthermore, the analysis of biomarkers indicated distinct bacterial species with significant dissimilarities between different MPBs, which further determined the associated functions.
View Article and Find Full Text PDFAs an advanced oxidation technology, photocatalytic treatment of red tide algae pollution was potential of great research prospects. However, the most commonly used photocatalyst TiO can only use ultraviolet light with short wavelength because of its wide band gap. In this study, the non-metallic elements S, N and P were added into the TiO (SNP-TiO) lattice by hydrothermal synthesis, and the inactivation effects and mechanisms of Karenia mikimotoi were studied under visible light.
View Article and Find Full Text PDFIn the Qinghai-Tibet Plateau of China, the yak is an animal of particular economic interest, which provides protein and income for herders in daily life. Brucellosis is a bacterial disease that can infect humans and animals, including yaks. It can damage the yak reproductive system, causing miscarriage and orchitis.
View Article and Find Full Text PDFHarmful algal blooms have deleterious effects on aquatic ecosystems and human health. The application of algicidal bacteria is a promising and environmentally friendly method of preventing and eradicating harmful algal blooms. In this study, a screen for algicidal agents against harmful algal blooms was used to identify an algicidal bacterial strain (strain O-4) isolated from a Karenia mikimotoi culture.
View Article and Find Full Text PDFBackground: Bovine tuberculosis (bTB), caused by members of the Mycobacterium tuberculosis complex bacteria, mainly Mycobacterium bovis (M. bovis), is a major threat to public health and economic development. There has been no systematic epidemiological assessment concerning bTB in dairy cattle in China.
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