Associations of lipids and lipid-modifying drug target genes with atrial fibrillation risk based on genomic data.

Background: The causal associations of lipids and the drug target genes with atrial fibrillation (AF) risk remain obscure. We aimed to investigate the causal associations using genetic evidence.

Methods: Mendelian randomization (MR) analyses were conducted using summary-level genome-wide association studies (GWASs) in European and East Asian populations.

Identification of hub genes within the CCL18 signaling pathway in hepatocellular carcinoma through bioinformatics analysis.

Introduction: Hepatocellular carcinoma (HCC) is an aggressive malignancy, and CCL18, a marker of M2 macrophage activation, is often associated with tumor immune suppression. However, the role of CCL18 and its signaling pathway in HCC is still limited. Our study focuses on investigating the prognostic impact of CCL18 and its signaling pathway in HCC patients and biological functions .

Intracardiac echocardiography guided electrified J-wire trans-septal puncture: A prospective randomized controlled trial.

Background: Application of electrocautery to a J-wire is used to perform transseptal puncture (TSP), but with limited evidence supporting safety and efficacy. We conducted a prospective randomized controlled trial to evaluate the safety and efficacy of this technique.

Methods: Two hundred consecutive patients were randomized in a 1:1 fashion to either the ICE-guided electrified J-wire TSP group or a conventional Brockenbrough (BRK) needle TSP group.

Experimental Research into the Uniaxial Compressive Strength of Low-Density Reef Limestone Based on Image Recognition.

Low-density reef limestone is widely distributed in tropical oceans; exploring its mechanical properties is of significance to practices in marine foundation engineering. In this research, laboratory experiments on low-density reef limestones with two different types of porous structures were conducted using image recognition methods to study the special mechanical properties of low-reef limestone. S¯ was defined as the parameter quantifying the pore geometry, and the calculation method of S¯ was optimized based on image recognition data.

Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer.

SETβ is the predominant isoform of oncoprotein SE translocation (SET) in various breast cancer cell lines. Interactome-transcriptome analysis has shown that SETβ is intimately associated with cellular stress response. Among various exogenous stimuli, formaldehyde (FA) causes distinct biological effects in a dose-dependent manner.

Intracardiac echocardiography is a safe and effective alternative to transesophageal echocardiography for left atrial appendage thrombus evaluation at the time of atrial fibrillation ablation: The ICE-TEE study.

Background: Intracardiac echocardiography (ICE) technology has been increasingly accepted as an integral part of atrial fibrillation (AF) ablation procedures. It is still unknown whether ICE can routinely replace transesophageal echocardiography (TEE) for routine thrombus screening in non-selective AF patients.

Objective: To assess whether ICE can routinely replace TEE in screening for left atrial (LA)/left atrial appendage (LAA) thrombus in general patients undergoing catheter ablation for AF.

SET/PP2A signaling regulates macrophage positioning in hypoxic tumor regions by amplifying chemotactic responses.

Tumor-associated macrophages (TAMs) are one of the main cellular components in the tumor microenvironment (TME). In many types of solid tumors, TAMs tend to accumulate in hypoxic areas and are intimately related to poor patient prognosis. However, the underlying mechanisms by which TAMs infiltrate hypoxic tumor regions remain unclear.

Vibration velocity and frequency characteristics of surrounding rock of adjacent tunnel under blasting excavation.

The aim of this study is to improve the accuracy of response prediction and safety evaluation of blasting vibration of a deeply-buried tunnel group. For this purpose, the expression of frequency-domain and blasting vibration velocity spectra for the equivalent blasting load in multiple holes was derived through theoretical analysis, and propagation and attenuation of the primary frequency of blasting vibration of multiple cutting holes and caving holes in the infinite rock mass were explored. Response characteristics of vibration frequency spectra in rock surrounding of the adjacent tunnel induced by full-section blasting excavation of the tunnel under the high in situ stress were studied using the dynamic finite element method.

Boosting Multilabel Semantic Segmentation for Somata and Vessels in Mouse Brain.

Deep convolutional neural networks (DCNNs) are widely utilized for the semantic segmentation of dense nerve tissues from light and electron microscopy (EM) image data; the goal of this technique is to achieve efficient and accurate three-dimensional reconstruction of the vasculature and neural networks in the brain. The success of these tasks heavily depends on the amount, and especially the quality, of the human-annotated labels fed into DCNNs. However, it is often difficult to acquire the gold standard of human-annotated labels for dense nerve tissues; human annotations inevitably contain discrepancies or even errors, which substantially impact the performance of DCNNs.