Performance of DNA methylation analysis in the detection of high-grade cervical intraepithelial neoplasia or worse (CIN3+): a cross-sectional study.

It is commonly accepted that host genes show high methylation in cervical intraepithelial neoplasia 3 (CIN3) or worse (CIN3+). However, study quality varies, as does the clinical performance of markers in different populations. We aimed to validate candidate gene DNA methylation with standardized testing methods in the same batch of samples.

ZNF671 methylation test in cervical scrapings for cervical intraepithelial neoplasia grade 3 and cervical cancer detection.

Effective triage of high-risk human papillomavirus (hrHPV)+ women is warranted to avoid unnecessary referral and overtreatment. Molecular triage tests have recently begun to impact cervical intraepithelial neoplasia grade 3 (CIN3) or cervical cancer (CC), termed CIN3+, detection. We find that zinc finger protein 671 methylation (ZNF671) test has superior performance for CIN3+ detection in all single molecular triage tests, including HPV16/18 genotyping, paired box gene 1 methylation (PAX1), and ZNF671, in the training set.

Traffic Vibration Signal Analysis of DAS Fiber Optic Cables with Different Coupling Based on an Improved Wavelet Thresholding Method.

Distributed Acoustic Sensing (DAS) is a novel technology that uses fiber optics to sense and monitor vibrations. It has demonstrated immense potential for various applications, including seismology research, traffic vibration detection, structural health inspection, and lifeline engineering. DAS technology transforms long sections of fiber optic cables into a high-density array of vibration sensors, providing exceptional spatial and temporal resolution for real-time monitoring of vibrations.

Aircraft Detection Using Phase-Sensitive Optical-Fiber OTDR.

Aircraft detection plays a vital role in aviation management and safe operation in the aviation system. Phase-Sensitive Optical Time Domain Reflectometry (Φ-OTDR) technology is a prevailing sensing method in geophysics research, structure inspection, transportation detection, etc. Compared with existing video- or radio-based detection methods, Φ-OTDR is cost-effective, suitable for long-distance detection, and resistant to severe weather conditions.