Publications by authors named "Yuh Sasawaki"
Article Synopsis
- Chronic jet-lag (CJL) affects wild-type mice differently, leading to varying levels of liver fat accumulation and highlighting the need for understanding these individual differences for better disease prevention.
- Researchers combined various methods, such as examining physiological and gene expression patterns, to identify how CJL impacts lipid metabolism and overall health in mice.
- The study found that stronger circadian rhythms in mice are linked to fewer health issues from CJL, suggesting that understanding these rhythms could help predict and manage circadian-related diseases.
Article Synopsis
- * Participants reported their sleep and eating patterns using various scales, including the Pittsburgh Sleep Quality Index and the Pediatric Daytime Sleepiness Scale.
- * Findings indicate that more than 2 hours of social jetlag correlates with very poor sleep quality and excessive daytime sleepiness, highlighting the need to limit social jetlag to under 2 hours.
Article Synopsis
- This study investigated the circadian clock's effect on gene expression in cultured human corneal endothelial cells (cHCECs) to understand its role in cell function.
- Researchers used a bioluminescence reporter to monitor circadian rhythms in cHCECs and performed RNA sequencing to identify genes with rhythmic expression.
- The results showed that cHCECs have a strong circadian clock, with 329 genes linked to important cellular processes displaying rhythmic expression, suggesting that this regulation helps the cells adapt to daily environmental changes.
Objectives: Irreversible morphological regressions of the teeth or related structures in older people can diminish their overall health. However, research on human aging in dentistry is complicated by several confounding factors. In this study, we conducted a morphometric analysis of the mandibular second molars and surrounding alveolar bone in C57BL/6 mice to evaluate age-related changes in the oral cavity.
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- Modern society's 24/7 lifestyle creates a disconnect between our natural body rhythms and environmental cycles, adversely affecting health over time.
- Research on mice subjected to chronic circadian misalignment revealed higher rates of early mortality and significant changes in immune system-related gene pathways in their liver and kidneys.
- The study suggests that this long-term misalignment worsens immune aging and chronic inflammation, highlighting the importance of maintaining immune balance to combat health issues linked to disrupted circadian rhythms.
The circadian clock regulates behavioural and physiological processes in a 24-h cycle. The nuclear receptors REV-ERBα and REV-ERBβ are involved in the cell-autonomous circadian transcriptional/translational feedback loops as transcriptional repressors. A number of studies have also demonstrated a pivotal role of REV-ERBs in regulation of metabolic, neuronal, and inflammatory functions including bile acid metabolism, lipid metabolism, and production of inflammatory cytokines.
View Article and Find Full Text PDFSeveral companies in Japan introduced early working conditions (including recommendations on early morning work and prohibitions on nighttime overtime work) to decrease the number of long working hours at night. Nevertheless, individuals possess their own chronotype, i.e.
View Article and Find Full Text PDFThe notion that sedentary behavior is harmful to human health is widespread. Little is known about the short term influence of sedentary behavior on heart rate (HR) and heart rate variability (HRV) circadian rhythms. Therefore the purpose of the present study was to examine the influence of short term sedentary behavior on the circadian rhythms of HR and HRV using cosine periodic regression analysis.
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