Publications by authors named "Yugyeong Sim"
Particulate matter ≤ 2.5 µm (PM2.5) poses health risks related to various diseases and infections.
View Article and Find Full Text PDFThe size of microplastics (MPs) plays an important role in combined toxic effects including synergistic or antagonistic effects. However, the influence of the size of MPs on the combined toxicity of contaminants remains unclear. In this study, we employed a zebrafish model to investigate the effects of MP size on the combined toxicity of benz[a]anthracene (BaA), a representative polyaromatic hydrocarbon, using three different sizes of polystyrene MPs (PSMPs) (0.
View Article and Find Full Text PDFNanoplastics (NPs) are emerging environmental pollutants and are a significant concern for human health. The small size of NPs allows them to accumulate within and adversely affect various tissues by penetrating the gastrointestinal barrier. However, most toxicity studies on NPs have been based on commercial polystyrene nanoparticles.
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- STAT3 is often activated in various cancers, and researchers identified Xanthium fruit extracts as a potential inhibitor that reduces its activation by decreasing p-STAT3-Y705 phosphorylation.
- 8-Epi-xanthatin (EXT) was isolated from these extracts, showing effectiveness at a concentration of 3.2 μM in lowering STAT3 activation and disrupting its target genes related to cell cycle and survival, ultimately triggering apoptosis in DU145 cancer cells.
- The study demonstrated that EXT binds to STAT3, inhibits its activity, and effectively reduces tumor growth in animal models, suggesting it could be a promising lead in cancer treatment development.