Publications by authors named "Yugo R Kamimura"
The number and variety of identified histone post-translational modifications (PTMs) are continually increasing. However, the specific consequences of each histone PTM remain largely unclear, primarily due to the lack of methods for selectively and rapidly introducing a desired histone PTM in living cells without genetic engineering. Here, we report the development of a cell-permeable histone acetylation catalyst, BAHA-LANA-PEG-CPP44, which selectively enters leukemia cells, binds to chromatin, and acetylates H2BK120 of endogenous histones in a short reaction time.
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- Peptides are useful for targeting proteins but face challenges like low membrane permeability and instability inside cells.
- Researchers developed a new fusion protein called PLIED, which uses a peptide to target proteins of interest and link them to small molecules that can easily enter cells.
- This method allows for precise modifications of specific protein residues, demonstrated by acetylating MDM2 and histone proteins, thereby enhancing the capabilities of chemical biology tools for cellular applications.