Accuracy of Velacur in Assessing MASLD and MASH Patients Using Biopsy as the Gold Standard.

: Velacur is a novel, point-of-care ultrasound device developed to accurately diagnose patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH). The Velacur system non-invasively assesses liver stiffness, attenuation, and the Velacurdetermined fat fraction (VDFF). In this study, the performance of Velacur was measured against biopsy results in a cohort of MASLD and MASH patients.

Trends in Choroidal Vascularity Index in Cognitively Normal Individuals.

Purpose: To establish a normative database of choroidal vascularity index (CVI) in cognitively normal adults.

Methods: Cognitively healthy volunteers who had a Montreal Cognitive Assessment (MoCA) score of 23 or higher were included. Exclusion criteria included diabetes mellitus, uncontrolled hypertension, glaucoma, optic neuropathy, vitreoretinal disorders, intraocular surgery other than cataract or refractive, and visual acuity worse than 20/40.

Postoperative Patient-reported Outcomes and Radiographic Findings Do Not Significantly Change Between 1 and 2 Years Postoperatively After Primary Anatomic Shoulder Arthroplasty.

Background: It is unclear if there are significant changes in clinical and radiographic outcomes between 1 and 2 years postoperatively after total shoulder arthroplasty (TSA). The current multi-center study sought to compare patient-reported outcome measures (PROMs), range of motion (ROM) and radiographic analysis of glenoid and humeral loosening between one and two-years postoperatively in a cohort of patients after primary anatomic TSA (aTSA).

Methods: A retrospective cohort of patients who underwent primary anatomic TSA between 2017 and 2018 at two high-volume shoulder arthroplasty centers and had baseline, one and two-year PROMs were included in the study.

Health Related Quality of Life in Adult Patients With Primary Glomerular Diseases.

Background: There is a growing need to understand how glomerular diseases impact patients' ability to lead a healthy and productive life. We examined the Health-Related Quality of Life (HRQoL) in patients with primary glomerular diseases in India.

Method: In a cross-sectional study, the Patient-Reported Outcomes Measurement Information System (PROMIS) 29v2.

Minimal clinical impact of embolization to new territory on outcomes in medium vessel occlusion strokes treated with mechanical thrombectomy: a retrospective multicenter study.

Background: Mechanical thrombectomy (MT) is established as an effective treatment for large vessel occlusion strokes, but its efficacy and safety for medium vessel occlusions (MeVOs) remain less clear. This study examines the impact of periprocedural embolization to a new vascular territory (ENT) on clinical outcomes in patients with MeVO stroke treated with MT.

Methods: A multicenter, retrospective analysis was conducted using the MAD-MT (Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy) registry, including 2122 patients with MeVO stroke w-ho underwent MT between September 2017 and July 2023.

Computational insights into the targeted inhibition of lipoxygenase in Pseudomonas aeruginosa: hints for drug design.

Pseudomonas aeruginosa is regarded as the most opportunistic pathogen. It can induce ferroptosis in humans. It secretes a unique lipoxygenase (LOX) isoform, pLoxA that can oxidize polyenoic fatty acids.

Microwave Imaging for Breast Cancer Detection: Performance Assessment of a Next-Generation Transmission System.

Unlabelled: Microwave imaging has been proposed for breast cancer detection and treatment monitoring. Prototype systems based on tomography and radar-based techniques have been tested on human subjects with promising results. Previously, we developed a system that estimated average permittivity in regions of the breast using signals transmitted through the tissues.

Open Treatment of Mandible Angle Fractures and the Role for Maxillomandibular Fixation.

Background: Maxillomandibular fixation (MMF) remains a mainstay in the treatment algorithm of bony injuries involving the lower facial skeleton to help restore premorbid occlusion.

Purpose: To compare postoperative open reduction and internal fixation outcomes in dentate patients with noncomminuted, isolated angle fractures of the mandible between patients that underwent postoperative MMF and those who did not.

Methods: Retrospective review of 224 patients treated for isolated, noncomminuted mandible angle fractures between January 1997 and December 2023.

Postdischarge health information tools and information needs for mothers of vulnerable newborns in low- and middle-income countries: a scoping review.

Objectives: The postdischarge period is crucial for vulnerable newborns at risk of morbidity, readmission and mortality in low- and middle-income countries (LMICs). Addressing gaps in care during this period could improve outcomes. This review consolidates evidence on caregiver information needs and relevant information tools used in postdischarge care for vulnerable newborns in LMICs.

Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: a mechanistic perspective.

Ischemia, also known as ischemia, relates to the reduced blood movement to a cells, muscle group, or organ in the body, culminating in an insufficient amount of oxygen required for cellular metabolism and the maintenance of tissue viability. There are different types of stroke (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage), and different causes of stroke (e.g.

Peripheral Intravenous (IV) cannulation should be avoided in the stroke affected upper limb.

Peripheral Intravenous (IV) cannulation is a common clinical procedure conducted in most stroke patients during their hospital admission. IV access is crucial in the hyperacute and re-habilitation phases of stroke care for administering lifesaving treatments, conducting investi-gations, managing secondary risk factors and treating stroke related complications. Despite its importance, peripheral IV cannulation can cause several complications including infection, thrombosis, and pain.

Care of Adult Heart Transplant Recipients by the Primary Care Provider: A Practical Roadmap.

Heart transplantation has significantly improved survival and enhanced the quality of life of patients with end-stage heart failure. Successful long-term outcomes are predicated on a collaborative effort among patients, transplant teams, and primary care providers (PCPs). Notably, PCPs are increasingly pivotal in post-transplant care, engaging in annual assessments, early recognition of complications, and referral, thus minimizing morbidity and mortality.

Beyond Survival: Assessing Quality of Life, Activity Level, and Ethnic Diversity in Aortic Dissection Survivors.

Background: An acute aortic dissection (AAD) is a highly lethal condition that demands immediate medical intervention. Survivors often face significant long-term challenges. While immediate survival remains a critical focus in acute care settings, little is known about long-term results, especially with regard to activity levels, post-operative quality of life, and the impact of cultural and ethnic characteristics on recovery.

The elusive relationship between retinal anatomy and brain amyloid.

This scientific commentary refers to 'Retinal microstructure and microvasculature in association with brain amyloid burden', by Egle . (https://doi.org/10.

Bleeding and New Malignancy Diagnoses After Anticoagulation for Atrial Fibrillation: A Population-Based Cohort Study.

Background: Bleeding after starting anticoagulation for atrial fibrillation (AF) may be the first sign of malignancy, especially in elderly individuals. There are no recommendations to guide investigations for malignancy after new-onset bleeding after anticoagulation for AF. Our objective was to determine the association of bleeding after starting oral anticoagulation for AF with new diagnoses of malignancy in a population-wide sample.

Incidence and Predictors of Growth Modulation and Overcorrection after Anterior Vertebral Body Tethering.

Study Design: Retrospective review of a prospectively collected single-center adolescent idiopathic scoliosis (AIS) database.

Objective: To evaluate the incidence and predictors of growth modulation and overcorrection after vertebral body tethering (VBT) in AIS.

Background: Little data exists regarding which AIS patients will exhibit growth modulation and/or overcorrection after VBT compared to those whose curve correction will remain unchanged (no modulation).

Unscrambling the cellular and molecular threads of Neuroplasticity: Insights into Alzheimer's disease pathogenesis.

Alzheimer's disease (AD) is predominantly the most recurring and devastating neurological condition among the elderly population, characterized by the accumulation of amyloid-β (Aβ) and phosphorylated tau proteins, and is accompanied by progressive decline of learning and memory. Due to its complex and multifactorial etiology, a wide variety of therapeutic interventions have been developed. Despite constant advancements in the field, effective treatments that ameliorate the severity of Alzheimer's symptoms or cease their progression are still insufficient.

Development and validation of BCG vaccine-induced novel granulomatous liver injury preclinical animal model.

Background: Developing a granulomatous liver injury preclinical model may pave the way to understanding hepatic-TB (tuberculosis) and autoimmune granulomatous liver diseases. Antitubercular (ATT) and other drugs' metabolism in the presence of a specific type of liver injury is not well understood. The present study aimed to establish a preclinical model of granulomatous hepatitis by using the BCG (Bacillus Calmette-Guérin) vaccine, further studying it in the presence of ATT dosing, and analyze the pharmacokinetics of isoniazid, rifampicin, and their respective primary metabolites.

Epithelioid Hemangioendothelioma (EHE) Mimicking Mesothelioma: Case Presentation and Review.

Epithelioid hemangioendothelioma (EHE) is an extremely rare vascular sarcoma that can initially present with a myriad of symptoms anywhere in the body. Imaging findings are often nonspecific, and the pathology tends to have overlap with other malignancies. As a result, it can be quite difficult to suspect and diagnose EHE.

The TRAIN Health Awareness Clinical Trial: Baseline Findings and Cardiovascular Risk Management in Aortic Dissection Patients.

Background/objective:  Acute Type A aortic dissection (ATAAD) is a life-threatening condition requiring timely surgical intervention. Despite successful surgery, postoperative outcomes are frequently suboptimal due to the high frequency of cardiovascular risk factors. This study examines baseline cardiovascular risk factors in a population of ATAAD patients in the Netherlands.

Exploring the Feasibility of Tele-Audiology in Rural Communities to Reduce Care Disparities for At-Risk Newborns.

Objective: To evaluate the efficacy and feasibility of a Utah Department of Health and Human Services (DHHS) program providing telehealth auditory brainstem response (tele-ABR) testing to rural families in order to reduce disparities in hearing loss (HL) diagnosis.

Study Design: This was a retrospective analysis of infants born at the Uintah Basin Medical Center from 2006 to 2021 who failed the newborn hearing screen (NBHS) and underwent ABR.

Setting: In-person ABRs were conducted at Primary Children's Hospital in Salt Lake City, UT.

Awake fiberoptic intubation in a pediatric patient with Tessier's cleft: Navigating the challenges.

Awake fibreoptic intubation is the gold standard of airway management in anticipated difficult airways. Paediatric patients with orofacial defects pose unique challenges to the anaesthetist as management requires meticulous planning and preparation as well as titration of drugs to maintain spontaneous ventilation without losing the airway. We report a case of an 11-year-old patient with Tessier cleft type 4,6 posted for orbital reconstruction and discuss the management with awake fibreoptic intubation.