Publications by authors named "Yug Patel"
Background: Neurosurgeons, especially spine surgeons, have the highest risk of facing a malpractice claim. Average verdicts in spine surgery litigation has been shown to be over USD $1 million/case. This systematic review aimed to clarify the impact of tort reforms on neurosurgical health care environments across the United States, including patient outcomes, practice of defensive medicine, and physician supply aims.
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- Alzheimer's Disease (AD) leads to memory loss and learning difficulties, primarily affecting older adults, and is linked to cholinergic deficiency, prompting the development of cholinesterase inhibitors for treatment.
- Recent innovations in AChE inhibitors have introduced novel compounds, such as coumarin-benzotriazole hybrids and carbazole derivatives, which enhance acetylcholine levels and may improve neural function.
- The studied compounds demonstrate effective inhibition of β-amyloid aggregation, low toxicity, and strong potential for targeting AChE in the treatment of Alzheimer's disease, showing promise for future therapeutic interventions.*
Parkinson's disease is a relatively common neurological disorder with incidence increasing with age. Since current medications only relieve the symptoms and do not change the course of the disease, therefore, finding disease-modifying therapies is a critical unmet medical need. However, significant progress in understanding how genetics underpins Parkinson's disease (PD) has opened up new opportunities for understanding disease pathogenesis and identifying possible therapeutic targets.
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