Publications by authors named "Yufu K"

Article Synopsis
  • Endothelial dysfunction may lead to coronary spastic angina (CSA) in young patients, with unclear risk factors highlighted in this study.
  • Researchers analyzed 423 patients, categorizing them by age and CSA status, finding that young CSA-positive patients had higher rates of smoking and serum uric acid levels.
  • In contrast, elderly CSA-positive patients showed higher proportions of males and alcohol consumption, suggesting different risk factors based on age; elevated serum uric acid levels in young patients are linked to CSA development.
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Background: The prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) in atrial fibrillation (AF) patients remains unclear. We explored the efficacy of computed tomography-based myocardial extracellular volume (CT-ECV) combined with red flags for the early screening of concealed ATTR-CM in AF patients undergoing catheter ablation.

Methods and results: Patients referred for AF ablation at Oita University Hospital were prescreened using the red-flag signs defined by echocardiographic or electrocardiographic findings, medical history, symptoms, and blood biochemical findings.

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Epicardial adipose tissue (EAT) have been shown to be associated with several heart disease, including coronary artery disease (CAD), atrial fibrillation (AF), and heart failure (HF). It is reported that the quality of EAT, represented by fat attenuation determined using computed tomography (CT) imaging, can detect the histologically-assessed remodeled EAT. We tested the hypothesis that quality of EAT would predict major adverse cerebral and cardiovascular events (MACCE) following transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis (AS).

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Background During the early phase of the coronavirus disease 2019 (COVID-19) pandemic, a global reduction in hospitalizations for acute myocardial infarction (AMI) was observed. Generally, patients experienced increased severity of AMI with delays in time from symptom onset to treatment during the pandemic. However, the impact of the COVID-19 pandemic on in-hospital mortality among patients with AMI remains unclear.

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Background: Typical left bundle branch block (LBBB) shows 2 peaks of the R wave, which reflect activation reaching the interventricular septum (R) and posterolateral wall (R') sequentially.

Objective: The purpose of this study was to investigate the relationship among R-R' interval (RR'), mechanical dyssynchrony, extent of viable myocardium, and long-term outcomes in cardiac resynchronization therapy (CRT) candidates.

Methods: The study enrolled 49 patients (34 men; mean age: 69 ± 11 years) with LBBB who received CRT.

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Background: The novel coronavirus disease (COVID-19) pandemic emerged in Japan in February 2020, forcing the adoption of online education by university medical schools across Japan. The advantages and disadvantages of online education have been studied in Japan; however, the educational outcome of online classes conducted during the COVID-19 pandemic has not been completely evaluated. In this study, we examined the relationship between lecture format (e.

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Article Synopsis
  • Sodium-glucose cotransporter 2 (SGLT2) inhibitors, like empagliflozin, are shown to reduce epicardial adipose tissue, which may provide benefits for heart health, particularly in heart failure and atrial fibrillation.
  • The study found that empagliflozin directly inhibits the differentiation of human preadipocytes into mature adipocytes without affecting their growth.
  • Additionally, empagliflozin treatment decreased levels of inflammatory markers in adipocytes and reduced harmful oxidative stress in heart cells, suggesting it improves the overall health of epicardial adipose tissue.
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Background: We have reported that a prehospital 12-lead electrocardiography system (P-ECG) contributed to transport of suspected acute coronary syndrome (ACS) patients to appropriate institutes and in this study, we compared its usefulness between urban and rural areas, and between weekday daytime and weekday nighttime/holiday.

Methods and results: Consecutive STEMI patients who underwent successful primary percutaneous coronary intervention after using P-ECG were assigned to the P-ECG group (n=123; 29 female, 70±13 years), and comparable STEMI patients without using P-ECG were assigned to the conventional group (n=117; 33 females, mean age 70±13 years). There was no significant difference in door-to-reperfusion times between the rural and urban cases (70±32 vs.

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Article Synopsis
  • n-3 polyunsaturated fatty acids (PUFAs), like EPA and DHA, are linked to reduced risk of ischemic heart disease, yet their relationship with coronary spastic angina (CSA) is unclear.
  • A study with 406 patients found that younger individuals with CSA had significantly higher serum levels of EPA and DHA compared to those without CSA, while this trend was not observed in older patients.
  • The findings suggest that elevated levels of EPA and DHA may play a role in the occurrence of CSA among younger patients, but not in the elderly.
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  • Recent research indicates that fat accumulation in the interatrial septum (IAS) may play a significant role in causing atrial fibrillation (AF), and this study explores how transesophageal echocardiography (TEE) can effectively assess IAS fat in AF patients.
  • The imaging results showed greater IAS fat volume relative to epicardial fat in patients with persistent AF compared to those with paroxysmal AF, suggesting a link between IAS adiposity and AF severity.
  • Histological analysis from autopsy samples revealed thicker IAS in AF patients and highlighted changes like "myocardial splitting" due to IAS fat infiltration, which may contribute to atrial cardiomyopathy associated with AF.
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Article Synopsis
  • * Researchers analyzed 164 AF patients who underwent ablation, finding that those with longer P-LAA (a measure of IACT) were older, had more severe AF cases, and presented a higher likelihood of recurrence of AF or atrial tachycardia post-ablation.
  • * The findings indicate that longer IACT (P-LAA ≥ 84 ms) and the presence of LVA are significant predictors of AF recurrence, highlighting the importance of these metrics
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Background: Wolff-Parkinson-White syndrome is characterized by a short PR interval (delta-wave), long QRS complex, and the appearance of paroxysmal supraventricular tachycardia. Patients with Wolff-Parkinson-White syndrome usually have one accessory pathway, whereas cases with multiple accessory pathways are rare. Persistent left superior vena cava is a vascular anomaly in which the vein drains into the right atrium through the coronary sinus at the junction of the left internal jugular and subclavian veins due to abnormal development of the left cardinal vein.

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  • Patients with early repolarization syndrome (ERS) and Brugada syndrome (BruS) experience similar symptoms like ventricular fibrillation (VF), but their risks for VF differ, particularly concerning autonomic nervous activity.
  • The study involved 50 patients, with 20 experiencing VF recurrence, focusing on baroreflex sensitivity (BaReS) and heart rate variability to assess autonomic function.
  • Results indicated that while heart rate variability was similar in both patient groups, ERS patients with recurrent VF had significantly higher BaReS, suggesting that an exaggerated vagal response could increase VF risk in ERS patients.
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Background: The outcome of catheter ablation could probably differ among patients with atrial fibrillation (AF), depending on age and AF type. We aimed to investigate the difference in predictors of outcome after catheter ablation for AF among the patient categories divided by age and AF type.

Methods And Results: A total of 396 patients with AF (mean age 65.

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Article Synopsis
  • Brugada syndrome (BrS) is linked to an increased risk of ventricular fibrillation (VF), but finding ways to assess this risk is difficult.
  • The study involved 21 patients with documented VF or syncope, testing their heart responses to drugs like verapamil, propranolol, and pilsicainide.
  • Results showed patients who experienced VF recurrence had a notable increase in J-wave amplitude after taking propranolol, suggesting that this response could help predict VF risk in patients with BrS.
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Aim: This study aimed to determine possible associations between sarcopenia and poor cardiovascular outcomes in patients with chronic heart failure after cardiac resynchronization therapy.

Methods: This retrospective study evaluated 120 patients who underwent cardiac resynchronization therapy between March 2004 and June 2018. In total, 58 patients who underwent computed tomography within 30 days of cardiac resynchronization therapy implantation were eligible for inclusion, and their data were analyzed (25 women; 33 men; mean age 71.

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Background: Mobile cloud electrocardiography (C-ECG) can reduce the door-to-balloon time of acute coronary syndrome (ACS) patients, so we hypothesized it would also assist in transporting ACS-suspected patients to the optimal institutes.

Methods and results: Initially, 10 fire departments in Oita had 10 ambulances equipped with C-ECG. Ambulance crews recorded a 12-lead ECG from the patient at the first point of contact and transmitted them to 18 hospitals (13 institutions (PCII) with 24-h availability for percutaneous coronary intervention (PCI) and 5 regional core hospitals (RCH) without 24-h PCI) for analysis by a cardiologist.

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Article Synopsis
  • A 70-year-old woman with cardiac sarcoidosis and severe mitral regurgitation was repeatedly hospitalized due to heart failure despite having a biventricular pacemaker.
  • MultiPoint™ pacing helped reduce the regurgitation volume and manage symptoms, but it shortened the device's lifespan due to high energy demands.
  • The patient underwent a transcatheter mitral valve repair using MitraClip® to further reduce regurgitation, allowing for a switch to more energy-efficient single-point pacing, demonstrating a potential bridging therapy approach.
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Background: Variant angina (VA) is caused by reversible coronary artery spasm, which is characterized by chest pain with ST-segment elevations on standard 12-lead electrocardiogram (ECG) at rest. Ventricular fibrillation (VF) is often caused by VA attack, but the risk stratification is not well understood. The purpose of this study was to evaluate the impact of fragmented QRS (fQRS) on VF occurrence in VA patients.

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Background: Reducing complications at the puncture site after percutaneous coronary intervention (PCI) is important. The diameter of a 6.5-French (Fr) sheathless guiding catheter (GC) is smaller by approximately 2-Fr compared to a 6-Fr conventional sheath.

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Background: Paradoxical low-flow, low-gradient (PLF-LG) aortic stenosis (AS) is associated with poor prognosis in patients undergoing transcatheter aortic valve implantation (TAVI). This study aimed to verify the conventional criteria of PLF-LG AS (left ventricular ejection fraction [LVEF] > 50%, mean aortic valve pressure gradient [AVPG] < 40 mm Hg and stroke volume index [SVI] < 35 ml/m by measuring Doppler method) compatible for predicting prognosis in patients undergoing TAVI.

Materials And Methods: A total of 128 consecutive patients who underwent TAVI for AS with LVEF > 50% were enrolled.

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We present a 66-year-old male patient with heart failure, mid-range ejection fraction and QRS widening suffering from recurrent hospitalization due to acute heart failure. We measured intra-cardiac pressure by cardiac catheterization to clearly demonstrate the augmentation of afterload by a vasoconstricting drug induced increase of left ventricular end-diastolic blood pressure and pulmonary capillary wedge pressure with pulmonary arterial V-wave augmentation (indicator of worsening of mitral regurgitation). Because the patient was considered as refractory to optimal medication, cardiac resynchronization therapy (CRT) was performed.

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Article Synopsis
  • Fibrotic remodeling of epicardial adipose tissue (EAT) is linked to atrial fibrillation (AF) and relates to adipocyte size differences in central versus marginal areas of EAT.
  • Research on 76 AF patients shows that smaller adipocyte diameters and more severe fibrosis occur in the marginal EAT compared to the central EAT, with a strong correlation found between the ratio of these diameters and the level of fibrosis.
  • Additionally, changes in EAT fat attenuation observed through CT imaging correlate with EAT fibrosis, indicating that this imaging technique can provide a non-invasive way to assess fibrotic remodeling.
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Article Synopsis
  • The Shanghai Score System effectively predicts which early repolarization syndrome (ERS) patients are at high risk for ventricular fibrillation (VF) recurrence.
  • During a follow-up of about 79 months, a significant difference in Shanghai Score points was found between patients who experienced VF recurrence and those who did not.
  • The study also highlighted that fragmented QRS (fQRS) patterns were much more common in patients who had VF recurrences, indicating potential depolarization abnormalities in this population.
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