Cardiac Electrical and Mechanical Synchrony Analysis of LBBP and RVP Utilizing Tissue Doppler Imaging Technology.

Background: Right ventricular pacing (RVP) therapy is the conventional approach for atrioventricular block despite its propensity to cause electrical and mechanical dyssynchrony. This dyssynchrony increases the risk of atrial fibrillation and heart failure, eventually leading to left ventricular dysfunction. Left bundle branch pacing (LBBP) has recently emerged as a novel physiological pacing method.

A novel homozygous variant in results in a neurodevelopmental disorder and disrupts TRAPP complex function.

Background: Next-generation sequencing has facilitated the diagnosis of neurodevelopmental disorders with variable and non-specific clinical findings. Recently, a homozygous missense p.(Asp37Tyr) variant in a core subunit of TRAPP complexes which function as tethering factors during membrane trafficking, was reported in two unrelated individuals with neurodevelopmental delay, post-infectious encephalopathy-associated developmental arrest, tetraplegia and accompanying rhabdomyolysis.

Cardiac electrical and mechanical synchrony of super-responders to cardiac resynchronization therapy.

Background: Super-responders (SRs) to cardiac resynchronization therapy (CRT) regain near-normal or normal cardiac function. The extent of cardiac synchrony of SRs and whether continuous biventricular (BIV) pacing is needed remain unknown. The aim of this study was to evaluate the cardiac electrical and mechanical synchrony of SRs.

Continuous Directional Water Delivery on the 3D-Printed Arrowhead Microstructure Array.

Unidirectional transport is attracting increasing attention in the field of microfluidics, because it does not require an external energy supply. However, most of the current self-driving structures are still plagued with persistent problems that restrict their practical applications. These include low transport velocity, short transport distance, and complex structure.

Enhanced electrochemiluminescent brightness and stability of porphyrins by supramolecular pinning and pinching for sensitive zinc detection.

Ultrasensitive electrochemiluminescence (ECL) detection can benefit substantially from the rational configuration of emitter-enhancer stereochemistry. Here, using zinc(II) meso-5,10,15,20-tetra(4-sulfonatophenyl)porphyrin (ZnTSPP) as a model, we demonstrate that both the ECL intensity and the photostability of this emitter were significantly improved when it was trapped in pyridyl-bridged β-cyclodextrin dimer (Py(CD)); a synthetic enhancer that is ECL inactive. Through NMR characterization, we confirmed that ZnTSPP formed a clam-like inclusion complex involving pinning and pinching forces from the biocompatible container Py(CD).

The incidence and outcomes of delayed response to cardiac resynchronization therapy.

Background: The incidence and clinical outcomes of delayed response to cardiac resynchronization therapy (CRT) have not been well clarified. We aimed to observe the incidence and prognosis of delayed response and to identify its possible mechanisms.

Methods: A total of 115 CRT patients were retrospectively analyzed in our study.