Publications by authors named "Yufeng Lin"

Heat transport in the subsurface is an important aspect of research related to the effects of a warming climate on ecological services (i.e., cold-water refugia); the development of geothermal resources for energy banking schemes (i.

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Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by motor and non-motor symptoms. It has been reported that astrocytes play a critical role in the pathogenesis and progression of PD. Here, we aimed to identify the heterogeneity of astrocytes and investigate genes associated with astrocyte differentiation trajectories in PD.

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This study investigated a library of known and novel glycyrrhizic acid (GL) conjugates with amino acids and dipeptide esters, as inhibitors of the DENV NS2B-NS3 protease. We utilized docking algorithms to evaluate the interactions of these GL derivatives with key residues (His51, Asp75, Ser135, and Gly153) within 10 Å of the DENV-2 NS2B-NS3 protease binding pocket (PDB ID: 2FOM). It was found that compounds and exhibited unique binding patterns, forming hydrogen bonds with Asp75, Tyr150, and Gly153.

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The hospital-at-home (HaH) model delivers hospital-level acute care, including diagnostics, monitoring, and treatments, in a patient's home. It is particularly effective for managing conditions such as pneumonia. Point-of-care ultrasonography (PoCUS) is a key diagnostic tool in the HaH model, and it often serves as a substitute for imaging-based diagnosis in the HaH setting.

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Background: Disulfidptosis is a novel form of cell death triggered by disulfide stress that may have important implications for breast cancer (BC) pathogenesis. Nevertheless, studies identifying disulfidptosis-associated long non-coding RNAs (lncRNAs) in BC have not been reported. This study aimed to investigate the prognostic potential of disulfidptosis-related lncRNAs in BC.

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  • * There is limited research on Siglecs in the context of neurological disorders, despite their importance in the development and repair of the nervous system.
  • * This review highlights the immunomodulatory functions of Siglecs in neurological conditions, the impact of dysregulated sialic acid on psychiatric disorders, and the current limitations in therapeutic research.
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Background: Gut bacteria are related to immune checkpoint inhibitors (ICIs). However, there is inconsistency in ICI-associated species, while the role of non-bacterial microbes in immunotherapy remains elusive. Here, we evaluated the association of trans-kingdom microbes with ICIs by multi-cohort multi-cancer analyses.

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The current diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) and its severe form, metabolic dysfunction-associated steatohepatitis (MASH), is suboptimal. Here, we recruited 700 individuals, including 184 from Hong Kong as a discovery cohort and 516 from San Diego, Wenzhou, and Hong Kong as three validation cohorts. A panel of 3 parameters (C-X-C motif chemokine ligand 10 [CXCL10], cytokeratin 18 fragments M30 [CK-18], and adjusted body mass index [BMI]) was formulated (termed N3-MASH), which discriminated patients with MASLD from healthy controls with an area under the receiver operating characteristic (AUROC) of 0.

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Background & Aims: Archaea are important components of the host microbiome, but their roles in colorectal cancer (CRC) remain largely unclear. We aimed to elucidate the contribution of gut archaea to CRC across multiple populations.

Methods: This study incorporated fecal metagenomic data from 10 independent cohorts across 7 countries and an additional in-house cohort, totaling 2101 metagenomes (748 CRC, 471 adenoma, and 882 healthy controls [HCs]).

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This study's objective was to observe the application effect of psychological counseling intervention based on the WeChat platform for patients with gastrointestinal tumors undergoing chemotherapy with completely implanted venous infusion ports. From October 2022 to December 2023, 110 patients with gastrointestinal tumors undergoing chemotherapy with completely implanted venous infusion ports were selected from our hospital. Patients were divided into 2 groups according to the different types of care.

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Background: Glioblastoma (GBM) exhibits diffuse and invasive growth patterns, with a 5-year overall survival (OS) rate of 5-10%. In addition, approximately 40 percent of GBMs are localized in the frontal lobe, a region closely linked to essential life functions including cognition, so that it cannot be completely eradicated through surgical intervention, leading to very poor prognosis. Postoperative therapy is an essential treatment modality.

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In recent decades, mangrove wetlands globally have suffered from human activities and climate change, leading to issues like area reduction, degraded ecological functions and declining biodiversity. Restoration efforts, primarily through mangrove afforestation (i.e.

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The abandoned pond-to-mangrove restoration project provides greater advantages than tidal flats afforestation in restoring mangrove ecosystem services and will be the primary method for mangrove restoration in the future. The existing methods for abandoned pond-to-mangrove restoration include artificial restoration through 'dike-breaking, filling with imported soil and tree planting' and natural restoration through 'dike-breaking and natural succession'. However, little is known about which restoration strategy (natural or artificial restoration) provides more benefits to the biodiversity of mangrove macrobethos.

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  • * The bacteria attach to CRC cells using a surface protein that activates pathways leading to tumor progression, making it a critical player in cancer development.
  • * P. stomatis contributes to resistance against treatments like EGFR and BRAF inhibitors, suggesting that it may hinder the effectiveness of common CRC therapies.
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Background: Energy homeostasis is vital for insects to survive food shortages. This study investigated the starvation tolerance of Spodoptera frugiperda, which invaded China in 2019, focusing on its storage protein family, crucial for energy balance. 10 storage protein family members were identified and their expression patterns at different development stages and under different starvation stress were analyzed.

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  • Breast cancer (BC) is the most common cancer among women, and while adjuvant chemotherapy is used post-surgery to target hidden cancer cells, tracking its effectiveness is difficult.
  • This study utilized proton nuclear magnetic resonance (NMR) to analyze serum samples from 61 BC patients and 51 healthy individuals pre- and post-chemotherapy, identifying key metabolites affected by the treatment.
  • Four metabolites (lactate, pyruvate, 1-methylhistidine, and formate) were found to accurately predict chemotherapy success, with a high sensitivity (98.36%) and specificity (91.30%), offering a promising non-invasive approach for monitoring treatment efficacy in breast cancer patients.
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  • * A structured approach called "KAMPS" focuses on monitoring kidney function, medication management, and patient advocacy to improve care for AKD patients, supported by a multidisciplinary team of healthcare professionals.
  • * Although research on AKD is limited, potential treatments like ACE inhibitors and SGLT2 inhibitors show promise, highlighting the need for further studies to enhance prognosis and outcomes.
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The phytochemical composition and physicochemical attributes of polyphenol-enriched protein particle ingredients produced with pulse proteins (e.g. chickpea protein, pea protein, and a chickpea-pea protein blend) and polyphenols recovered from wild blueberry pomace were investigated for colloidal and interfacial properties.

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Triple-negative breast cancer (TNBC) lacks sensitivity to endocrine and targeted therapies, exhibiting high recurrence and poor prognosis postchemotherapy. Tumor-associated macrophages (TAMs) play a crucial role in cancer progression. Vitexin, a compound with diverse pharmacological effects including anti-cancer activity, remains unexplored in its impact on TAMs during TNBC development.

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Taurine (Tau) has been found to inhibit triple-negative breast cancer (TNBC) invasion and metastasis. However, its effect on tumor-promoting macrophages and tumor suppressor macrophages in breast cancer progression remains unknown. In this study, we investigated the effects of Tau on macrophage polarization and its role in TNBC cell growth, invasion, and metastasis.

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The miniaturization of biomedical microrobots is crucial for their applications. However, it is challenging to reduce their size while maintaining their biomedical functions. To resolve this contradiction, we propose a semiphysical design concept for developing miniaturized microrobots, in which invisible components such as light beams are utilized to replace most of the physical parts of a microrobot, thus minimizing its physical size without sacrificing its biomedical functions.

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  • * Results show that an Al-Ga-In sacrificial anode with 4% Pb and 1% Bi achieves the best performance, while too much Bi leads to poor current efficiency due to uneven dissolution.
  • * The process involves preferential dissolution of a second phase that disrupts the protective oxide film on aluminum, allowing metal ions to redeposit and enhance continuous anode dissolution.
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Background: There is currently no well-accepted consensus on the association between gut microbiota and the response to treatment of immune checkpoint inhibitors (ICIs) in patients with advanced cancer.

Methods: Fecal samples were collected before ICI treatment. Gut microbiota was analyzed using 16 S ribosomal RNA sequencing.

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  • The rice root-knot nematode has spread widely in China, particularly causing problems in Hunan Province, prompting a study of its population dynamics in different rice farming systems.
  • The study found that the nematode's population density in soil was significantly influenced by the type of agroecosystem, rainfall, and temperature, with higher densities observed in dry and rain-fed upland systems compared to lowland environments.
  • It suggests that field flooding can help reduce nematode populations, and proposes that nematodes might lay their eggs inside rice roots during high moisture conditions but move to lay eggs outside the roots when moisture levels are more suitable.
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Background: Gut probiotic depletion is associated with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC). Here, we investigated the prophylactic potential of Lactobacillus acidophilus against NAFLD-HCC.

Methods: NAFLD-HCC conventional and germ-free mice were established by diethylnitrosamine (DEN) injection with feeding of high-fat high-cholesterol (HFHC) or choline-deficient high-fat (CDHF) diet.

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