Triiodothyronine activates THRβ to promote PGC1α expression alleviating PQ-induced pulmonary fibrosis.

Thyroid hormone (TH) and it most active form triiodothyronine (T3) are crucial in promoting mitochondrial biogenesis and maintaining cellular homeostasis during the stress response, but their role in paraquat (PQ)-induced pulmonary fibrosis isunclear. The aim of this study was to examine whether there was a deficiency of TH in mouse lung tissue after PQ administration, and to explore the effect of T3, and potential mechanisms of action, in alleviation of PQ-induced pulmonary fibrosis. We found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, were higher in the lungs of patients with pulmonary fibrosis than in controls.

Study on the role of mitophagy and pyroptosis induced by nano-silver in testicular injury.

Silver nanoparticles(AgNPs)have been widely used in biomedicine and industry. Growing studies have shown that AgNPs can induce sperm motility decrease and spermiogenesis disorders. In this study, animal experiments were used to investigate the role of mitophagy and pyroptosis caused by AgNPs (25.

Hypocretenolides: collective total syntheses and activities toward metastatic colon cancer.

A concise and collective synthetic route to hypocretenolides was developed for the first time. This route features one-pot addition-alkylation and intramolecular 1,3-dipolar cycloaddition to efficiently assemble the 5/7/6 ring system. Our syntheses enabled multigram preparation of hypocretenolide which facilitated further biological evaluation.

Total Syntheses of Brassicicenes A, R, and T.

Here, we report concise and divergent total syntheses of fusicoccane members brassicicenes A, R, and T. The key feature of the synthesis is the rapid construction of the 5/8/5 tricyclic core via four steps: aldol reaction, Stork-Danheiser transposition, and ring-closing metathesis from known compounds followed by concise oxidation state adjustment.

Therapeutic effect of the sulforaphane derivative JY4 on ulcerative colitis through the NF-κB-p65 pathway.

The efficacy of the sulforaphane derivative JY4 was evaluated in acute and chronic mouse models of ulcerative colitis induced by dextran sodium sulfate. Oral administration of JY4 led to significant improvements in symptoms, with recovery of body weight and colorectal length, together with reduced diarrhoea, bloody stools, ulceration of colonic tissue and infiltration of inflammatory cells. The oral bioavailability of JY4, determined by comparing oral dosing with injection into the tail vein, was 5.

Operating Room Planning for Emergency Surgery: Optimization in Multiobjective Modeling and Management from the Latest Developments in Computational Intelligence Techniques.

This study presents an optimization approach for scheduling the operation room for emergency surgeries, considering the priority of surgeries. This optimization model aims to minimize the costs associated with elective and emergency surgeries and maximize the number of scheduled surgeries. In this study, surgeon assistants to perform each surgery are considered in order to achieve the goals.

Specific metabolism related to sulfonamide tolerance and uptake in wetland plants.

Wetland plants are proven to perform well in water treatment. However, the phytoremediation capability of wetland plants for antibiotics, especially the uptake and metabolism involved in vivo, is poorly understood. In this study, we investigated the removal, uptake, and specific metabolism by Canna indica and Iris pseudacorus of five sulfonamides (SAs) using hydroponic experiments for seven days.

Enhanced removal of Microcystis bloom and microcystin-LR using microcosm constructed wetlands with bioaugmentation of degrading bacteria.

The prevalence of cyanobacterial bloom (Cyano-bloom) and hepatotoxic microcystin (MC) pollution caused by eutrophication poses serious problems to aquatic ecosystems and public health. However, conventional water treatment technologies are inefficient for removing cyanotoxins. In this study, the performance of microcosm constructed wetlands (CWs) in the removal of Cyano-bloom, microcystin-LR (MC-LR), and nutrients was investigated following repeated loading of pollutants.

Phytoextraction of 55-year-old wastewater-irrigated soil in a Zn-Pb mine district: effect of plant species and chelators.

Untreated water from mining sites spreads heavy metal contamination. The present study assessed the phytoextraction performance of heavy metal-accumulating plants and the effects of chemical chelators on cadmium (Cd), lead (Pb), zinc (Zn), and copper (Cu) removal from paddy fields that have been continuously irrigated with mining wastewater from mines for 55 years. Outdoor pot experiments showed that the total Pb, Zn, and Cd content was lower in the rhizosphere soil of Amaranthus hypochondriacus than in that of Sedum alfredii, Solanum nigrum, and Sorghum bicolor.

Nitrogen-Doped Hollow Carbon Nanospheres for High-Performance Li-Ion Batteries.

N-doped carbon materials is of particular attraction for anodes of lithium-ion batteries (LIBs) because of their high surface areas, superior electrical conductivity, and excellent mechanical strength, which can store energy by adsorption/desorption of Li at the interfaces between the electrolyte and electrode. By directly carbonization of zeolitic imidazolate framework-8 nanospheres synthesized by an emulsion-based interfacial reaction, we obtained N-doped hollow carbon nanospheres with tunable shell thickness (20 nm to solid sphere) and different N dopant concentrations (3.9 to 21.

Effectiveness of a cross-circuit exercise training program in improving the fitness of overweight or obese adolescents with intellectual disability enrolled in special education schools.

This study assessed the effects of a cross-circuit training intervention program on the body composition, cardiorespiratory fitness, balance, and muscular strength endurance of overweight or obese students with intellectual disability. A total of 43 students with intellectual disability (aged 13-19 years) were enrolled in this program; 28 overweight/obese students were assigned to either an obesity-control group (n=14) or obesity-exercise group (n=14), and those with normal weight were assigned to a normal weight group (n=15). The experiment was divided into three periods: pretest (involving the three groups), exercise intervention (involving only the obesity-exercise group), and post-test (involving the obesity-exercise and obesity-control groups).

Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.

Recently, a large meta-analysis of five genome wide association studies (GWAS) identified a novel locus (rs2718058) adjacent to NME8 that played a preventive role in Alzheimer's disease (AD). However, this link between the single nucleotide polymorphism (SNP) rs2718058 and the pathology of AD have not been mentioned yet. Therefore, this study assessed the strength of association between the NME8 rs2718058 genotypes and AD-related measures including the cerebrospinal fluid (CSF) amyloid beta, tau, P-tau concentrations, neuroimaging biomarkers and cognitive performance, in a large cohort from Alzheimer's Disease Neuroimaging Initiative (ADNI) database.

Hollow metal-organic framework nanospheres via emulsion-based interfacial synthesis and their application in size-selective catalysis.

Metal-organic frameworks (MOFs) represent an emerging class of crystalline materials with well-defined pore structures and hold great potentials in a wide range of important applications. The functionality of MOFs can be further extended by integration with other functional materials, e.g.

Residues of fluoroquinolones in marine aquaculture environment of the Pearl River Delta, South China.

Concentrations and distributions of selected fluoroquinolones (norfloxacin, ciprofloxacin and enrofloxacin) in water, sediments and nine kinds of fish species collected from 6 sites in two marine aquaculture regions of the Pearl River Delta, China, were analyzed by using high-performance liquid chromatography with fluorescence detector (HPLC). The results showed that the concentrations of ciprofloxacin and enrofloxacin were below the limits of quantification (LOQ) in all water samples except for norfloxacin. Norfloxacin and ciprofloxacin concentrations ranged from 1.

Aberrant RNA splicing in RHD 7-9 exons of DEL individuals in Taiwan: a mechanism study.

Background: The Rh blood D group provides a clinically important model of aberrant splicing with skipped exons. Approximately 30% of serologically D-negative Chinese individuals have an intact RHD gene (DEL phenotype) and induce allo-immunization in transfusions. The RHD1227GNA polymorphism occurs in >95% DEL phenotype of Asian descent.

[Biodehydrogenation of 11beta-hydroxyl melroxyprogesterone by Arthrobacter simplex UR016 in microemulsion system].

To improve mass transfer and enhance the yield for C(1,2) biodehydrogenation of steroid 11beta-hydroxyl medroxyprogesterone, we carried out the dehydrogenation reaction of 11beta-hydroxyl medroxyprogesterone in an oil-in-water (O/W) microemulsion by Arthrobacter simplex UR016. We studied the effects of system composition, dehydrogenation temperature and substrate concentration on microbial transformation. We formulated a suitable O/W microemulsion system with Arthrobacter simplex UR016 culture broth as aqueous phase, 10 g/L of edible oil as oil phase, 4 g/L of Tween-O80 and 7% (V/V) alcohol as surfactant and cosurfactant.

Effects of norfloxacin and butylated hydroxyanisole on the freshwater microalga Scenedesmus obliquus.

The toxic effects of norfloxacin (NOR) and butylated hydroxyanisole (BHA) on the microalga Scenedesmus obliquus were assessed in terms of growth rate, concentration of chlorophyll a, activities of 7-ethoxyresorufin-o-dealkylases (EROD), glutathione s-transferase (GST), catalase (CAT) and total malondialdehyde content (MDA). The 96 h EC(50) was 38.49 and 11.

Prevalence of RHD 1227A and hybrid Rhesus box in the general Chinese population.

The Rhesus (Rh) blood group is the most polymorphic blood group system. Serological analyses revealed that only 0.1% to 0.

Surface modification of purified fly ash and application in polymer.

With the growing general concern about the pollution by fly ash (FA), there has been global interest in its utilization. Purified FA or FA micro-beads are suitable as polymer filling materials because of their density, good dispersity and fluidity of globular particles. However, FA as a filler has not been widely used up to now on account of low whiteness values and low friction of untreated FA surface.

Detection of RhD(el) in RhD-negative persons in clinical laboratory.

The Rhesus (Rh) blood group is the most polymorphic human blood group system, and it is clinically significant in transfusion medicine. About 15% of Caucasoid people are RhD-negative, whereas in the Asian population, the RhD-negative blood type only occurs in 0.1% to 0.