A motor bearing fault diagnosis model based on multi-adversarial domain adaptation.

In response to the weakened capability of feature transfer and parameter distribution alignment across domains due to significant differences in data distribution collected by different devices, this paper constructs a motor bearing fault diagnosis model based on multi-adversarial domain adaptation. Initially, an improved residual network is employed as the feature extraction module to enhance feature extraction capabilities. It then incorporates a Selective Kernel Network (SKNet) to implement attention mechanisms on convolutional kernels, and a Global Context Network (GCNet) to effectively utilize global contextual information for re-weighting across different channels.

Investigating Microperimetric Features in Bietti Crystalline Dystrophy Patients: A Cross-Sectional Longitudinal Study in a Large Cohort.

Purpose: To assess the clinical and genetic characteristics of patients with Bietti crystalline dystrophy (BCD) with a focus on potential of microperimetry in monitoring macular function.

Methods: A total of 208 genetically-confirmed BCD patients were enrolled in this retrospective study. The patients were categorized into subgroups based on their fundus characteristics (fovea sparing and fovea involved), optical coherence tomography (OCT) findings (presence/absence of retinal pigment epithelium [RPE] or ellipsoid zone [EZ] line at the fovea/parafovea), and genetic profiles (Mis/Mis, Tru/Mis, Tru/Tru).

[Application of chimeric antigen receptor macrophage (CAR-M) therapy in the treatment of inflammation-associated depression].

The classic Chimeric Antigen Receptor Macrophage (CAR-M) exerts pro-inflammatory effects to achieve anti-tumor immunity, but by modifying the structure design of CAR, it can acquire anti-inflammatory functions similar to M2, thereby treating inflammatory diseases. Currently, CAR-M therapy targeting M1-type microglial cells can effectively reduce neuroinflammation and be used to treat inflammation-related depression. With ongoing research on the anti-inflammatory effects of CAR-M, CAR-M cell therapy offers a new approach for treating inflammatory-related diseases.

An Efficient Approach for Advancing Performance in Rapid Detection Based on Molybdenum Disulfide Nanoflower Supported Binary Transition Metal Oxides.

Binary transition metal oxides (BTMOs) have drawn considerable attention in recent years for their excellent catalytic properties and chemical stability in the sensing field. Regrettably, the loss of active site exposure originating from the agglomerate during preparation largely restricted their sensing applications. In this work, we report an efficient strategy for advancing the performance of BTMOs in rapid detection based on a 3D molybdenum disulfide nanoflower.

Chromosome-level genome assembly and annotation of Clanis bilineata tsingtauica Mell (Lepidoptera: Sphingidae).

The soybean hawkmoth Clanis bilineata tsingtauica Mell (Lepidoptera, Sphingidae; CBT), as one of the main leaf-chewing pests of soybeans, has gained popularity as an edible insect in China recently due to its high nutritional value. However, high-quality genome of CBT remains unclear, which greatly limits further research. In the present study, we assembled a high-quality chromosome-level genome of CBT using PacBio HiFi reads and Hi-C technologies for the first time.

Gender Differences in the Longitudinal Linkages between Fear of COVID-19 and Internet Game Addiction: A Moderated Multiple Mediation Model.

Background: The COVID-19 outbreak has profoundly affected the psychological well-being of university students globally. Previous studies have found a positive longitudinal link between fear of COVID-19 (FoC-19) and internet addiction. However, there is a notable gap in the literature regarding COVID-19-specific predictors and underlying mechanisms of internet gaming addiction (IGA).

The biological impact of deuterium and therapeutic potential of deuterium-depleted water.

Since its discovery by Harold Urey in 1932, deuterium has attracted increased amounts of attention from the scientific community, with many previous works aimed to uncover its biological effects on living organisms. Existing studies indicate that deuterium, as a relatively rare isotope, is indispensable for maintaining normal cellular function, while its enrichment and depletion can affect living systems at multiple levels, including but not limited to molecules, organelles, cells, organs, and organisms. As an important compound of deuterium, deuterium-depleted water (DDW) possess various special effects, including but not limited to altering cellular metabolism and potentially inhibiting the growth of cancer cells, demonstrating anxiolytic-like behavior, enhancing long-term memory in rats, reducing free radical oxidation, regulating lipid metabolism, harmonizing indices related to diabetes and metabolic syndrome, and alleviating toxic effects caused by cadmium, manganese, and other harmful substances, implying its tremendous potential in anticancer, neuroprotective, antiaging, antioxidant, obesity alleviation, diabetes and metabolic syndrome treatment, anti-inflammatory, and detoxification, thereby drawing extensive attention from researchers.

Unveiling the therapeutic promise: exploring Lysophosphatidic Acid (LPA) signaling in malignant bone tumors for novel cancer treatments.

Malignant bone tumors, including primary bone cancer and metastatic bone tumors, are a significant clinical challenge due to their high frequency of presentation, poor prognosis and lack of effective treatments and therapies. Bone tumors are often accompanied by skeletal complications such as bone destruction and cancer-induced bone pain. However, the mechanisms involved in bone cancer progression, bone metastasis and skeletal complications remain unclear.

Sex-specific difference in phenotype of Kabuki syndrome type 2 patients: a matched case-control study.

Background: Kabuki syndrome (KS) is a monogenic disorder leading to special facial features, mental retardation, and multiple system malformations. Lysine demethylase 6A, (KDM6A, MIM*300128) is the pathogenic gene of Kabuki syndrome type 2 (KS2, MIM#300867), which accounts for only 5%-8% of KS. Previous studies suggested that female patients with KS2 may have a milder phenotype.

Vision Transformer With Quadrangle Attention.

Window-based attention has become a popular choice in vision transformers due to its superior performance, lower computational complexity, and less memory footprint. However, the design of hand-crafted windows, which is data-agnostic, constrains the flexibility of transformers to adapt to objects of varying sizes, shapes, and orientations. To address this issue, we propose a novel quadrangle attention (QA) method that extends the window-based attention to a general quadrangle formulation.

Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities.

Background: Pathogenic variants in the centrosome protein (CEP) family have been implicated in primary microcephaly, Seckel syndrome, and classical ciliopathies. However, most CEP genes remain unlinked to specific Mendelian genetic diseases in humans. We sought to explore the roles of CEP295 in human pathology.

Efficacy of four anti-vascular endothelial growth factor agents and laser treatment for retinopathy of prematurity: A network meta-analysis.

This study undertakes a comprehensive comparison of five different interventions for the treatment of type-1 retinopathy of prematurity (ROP) and aggressive posterior ROP (APROP), offering insights into their relative efficacies and contributing to better clinical decision making. The aim of this study was to compare the efficacy of intravitreal aflibercept (IVA), intravitreal bevacizumab (IVB), intravitreal conbercept (IVC), intravitreal ranibizumab (IVR), and laser therapy in treating these conditions. We conducted a search for relevant randomized controlled trials (RCTs) in databases, namely, PubMed, Embase, Cochrane Library, Web of Science, and Ovid, focusing on these five treatment modalities for ROP.

ViTPose++: Vision Transformer for Generic Body Pose Estimation.

In this paper, we show the surprisingly good properties of plain vision transformers for body pose estimation from various aspects, namely simplicity in model structure, scalability in model size, flexibility in training paradigm, and transferability of knowledge between models, through a simple baseline model dubbed ViTPose. ViTPose employs the plain and non-hierarchical vision transformer as an encoder to encode features and a lightweight decoder to decode body keypoints in either a top-down or a bottom-up manner. It can be scaled to 1B parameters by taking the advantage of the scalable model capacity and high parallelism, setting a new Pareto front for throughput and performance.

Clinical characteristics and genetic expansion of 46,XY disorders of sex development children in a Chinese prospective study.

Diagnosis and management strategy of disorders of sex development (DSD) are difficult and various due to heterogeneous phenotype and genotype. Under widespread use of genomic sequencing technologies, multiple genes and mechanisms have been identified and proposed as genetic causes of 46,XY DSD. In this study, 178 46,XY DSD patients were enrolled and underwent gene sequencing (either whole-exome sequencing or targeted panel gene sequencing).

Genome-Wide Identification and Analysis of the Hsp40/J-Protein Family Reveals Its Role in Soybean () Growth and Development.

The J-protein family comprises molecular chaperones involved in plant growth, development, and stress responses. Little is known about this gene family in soybean. Hence, we characterized J-protein genes in soybean, with the most highly expressed and responsive during flower and seed development.

ACCURACY OF NEW INTRAOCULAR LENS CALCULATION FORMULAE IN EYES UNDERGOING SILICONE OIL REMOVAL/PARS PLANA VITRECTOMY-CATARACT SURGERY.

Purpose: To investigate the performance of novel intraocular lens calculation formulae (Barrett Universal II, Emmetropia Verifying Optical, and Kane) and conventional formulae (Haigis, Hoffer Q, Holladay 1, and Sanders-Retzlaff-Kraff/T [SRK/T]) in patients who underwent pars plana vitrectomy or silicone oil removal combined with cataract surgery.

Methods: In total, 301 eyes from 301 patients who underwent pars plana vitrectomy/silicone oil removal with concomitant cataract surgery were enrolled and divided into the following four groups according to preoperative diagnosis: silicone oil-filled eyes after pars plana vitrectomy, epiretinal membrane, primary retinal detachment, and macular hole.

Results: Barrett Universal II exhibited the smallest mean absolute error (0.

Bedside nurses' antimicrobial stewardship practice scope and competencies in acute hospital settings: A scoping review.

Aim: To identify and map bedside nurses' practice scope and competencies regarding antimicrobial stewardship in acute hospital settings, and develop a competency framework for them.

Background: Antimicrobial stewardship requires multidisciplinary engagement including nursing. However, bedside nurses' antimicrobial stewardship practice scope and competencies in acute hospital settings remain unclear.

Outcomes and risk factors for failure of trabeculectomy in glaucomatous patients in Southwest China: a 325 eyes analysis.

Aim: To evaluate the outcomes and elucidate the failure factors for trabeculectomy with mitomycin C (MMC) in Southwest Chinese patients.

Methods: A retrospective correlational study was conducted on the glaucomatous patients who underwent initial trabeculectomy with MMC in Southwest Hospital and had been followed up for 1-3y. A complete success for surgery is defined as a postoperative intraocular pressure (IOP) >5 and ≤21 mm Hg and 20% reduction of IOP compared to preoperative, without IOP-lowering medications.

Experimental Analysis and Establishment of Strength Attenuation Model of POM Fiber Reinforced Geopolymeric Recycled Concrete under Freeze-Thaw Cycles.

Geopolymeric recycled concrete (GRC) is a new low-carbon building material that uses both construction and industrial solid waste to replace natural aggregate and cement. GRC is similar to geopolymeric concrete (GPC) in that it has good mechanical properties but needs to be improved in terms of frost resistance. Previous studies have shown that polyoxymethylene fiber (POM fiber) can improve the shrinkage and durability of concrete and is superior to other commonly used fibers.

Design of field real-time target spraying system based on improved YOLOv5.

Deep learning techniques have made great progress in the field of target detection in recent years, making it possible to accurately identify plants in complex environments in agricultural fields. This project combines deep learning algorithms with spraying technology to design a machine vision precision real-time targeting spraying system for field scenarios. Firstly, the overall structure scheme of the system consisting of image acquisition and recognition module, electronically controlled spray module and pressure-stabilized pesticide supply module was proposed.

Immune-based combination therapy for esophageal cancer.

Esophageal cancer (EC) is an aggressive malignancy raising a healthcare concern worldwide. Standard treatment options include surgical resection, chemotherapy, radiation therapy, and targeted molecular therapy. The five-year survival rate for all stages of EC is approximately 20%, ranging from 5% to 47%, with a high recurrence rate and poor prognosis after treatment.

Mechanism of downward migration of quinolone antibiotics in antibiotics polluted natural soil replenishment water and its effect on soil microorganisms.

Reclaimed water is widely concerned as an effective recharge of groundwater and surface water, but trace organic pollutants produced by traditional wastewater treatment plants (WWTPs) would cause environmental pollution (water and soil) during infiltration. Therefore, the effects of reclaimed water containing ofloxacin (OFL) and ciprofloxacin (CIP) in antibiotics polluted natural soil (APNS) were investigated by simulating soil aquifer treatment systems (SATs). The experiment results showed that OFL and CIP in water were adsorbed and microbially degraded mainly at 30 cm, and the concentration of OFL and CIP in soil increased with depth, which were mainly due to the desorption from APNS.

The current landscape of predictive and prognostic biomarkers for immune checkpoint blockade in ovarian cancer.

Immune checkpoint blockade (ICB) therapy has evoked a prominent shift in anticancer therapy. Durable clinical antitumor activity to ICB has been observed in patients with ovarian cancer (OC). However, only a subset of patients derive clinical benefit, and immune-related adverse events (irAEs) caused by ICB therapy can lead to permanent tissue damage and even fatal consequences.

NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step.

Interstrand crosslinks (ICLs) repair by the canonical Fanconi anemia (FA) pathway generates double-strand breaks (DSBs), which are subsequently repaired by the homologous recombination (HR) pathway. Recent studies show that the NEIL3 DNA glycosylase repairs psoralen-ICLs by direct unhooking. However, whether and how NEIL3 regulates MMC and cisplatin-ICL repair remains unclear.