Publications by authors named "Yufei Qu"
Exosomal CircMFN2 Enhances the Progression of Pituitary Adenoma via the MiR-146a-3p/TRAF6/NF-κB Pathway.
J Neurol Surg A Cent Eur Neurosurg
March 2025
Background: Pituitary adenoma (PA) is a common intracranial endocrine tumor, but no precise target has been found for effective prediction and treatment of PA.
Methods: Quantitative reverse transcription polymerase chain reaction (qRT‒PCR) analysis showed that circMFN2 could affect the expression of miR-146a-3p in PA samples. Moreover, we used Western blotting to evaluate the expression levels of TRAF6 and NF-κB markers.
Article Synopsis
- - Alcoholism poses significant health risks, causing severe damage to individuals, and recent research explored the protective effects of chitosan oligosaccharides (COSs) on alcohol-related brain injuries in rats.
- - In experiments, rats treated with COS showed a 59.3% improvement in cognitive function compared to those that consumed alcohol, with noticeable differences in brain cell arrangements and recognition test results.
- - Proteomic analysis revealed 27 proteins that varied between the COS and alcohol groups, with key signaling pathways identified, including the hedgehog and sulfur relay systems, indicating COS might enhance brain function by influencing specific proteins like β-arrestin-2.
Parkinson's disease (PD), the second most common neurodegenerative disease, is a threat to patients due to the inability to prevent or decelerate disease progression. Currently, most clinical drugs for the treatment of PD are synthetic drugs that always present undesirable adverse or toxic effects. Chitosan oligosaccharide (COS) is a natural oligosaccharide that has been considered relatively safe and studied in the therapeutic effects on different types of neuronal disorders.
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