Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression.

Background: Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer. The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high ITH tumors.

Methods: We developed a mouse model of lung adenocarcinoma with defined expression of different neoantigens (NeoAg), enabling us to analyze how these impact antitumor T-cell immunity and to study underlying mechanisms.

Validation and quantification of peptide antigens presented on MHCs using SureQuant.

Vaccines and immunotherapies that target peptide-major histocompatibility complexes (peptide-MHCs) have the potential to address multiple unmet medical needs in cancer and infectious disease. Designing vaccines and immunotherapies to target peptide-MHCs requires accurate identification of target peptides in infected or cancerous cells or tissue, and may require absolute or relative quantification to identify abundant targets and measure changes in presentation under different treatment conditions. Internal standard parallel reaction monitoring (also known as 'SureQuant') can be used to validate and/or quantify MHC peptides previously identified by using untargeted methods such as data-dependent acquisition.

Sulfur-carbon loop enhanced efficient nitrogen removal mechanism from iron sulfide-mediated mixotrophic partial denitrification/anammox systems.

This study successfully established Iron Sulfide-Mediated mixotrophic Partial Denitrification/Anammox system, achieving nitrogen and phosphorus removal efficiency of 97.26% and 78.12%, respectively, with COD/NO-N of 1.

Interactions between nitrogen and phosphorus in modulating soil respiration: A meta-analysis.

Background: Economic and social development worldwide increases the input of nutrients, especially nitrogen (N) and phosphorus (P), to soils. These nutrients affect soil respiration (Rs) in terrestrial ecosystems. They may act independently or have interactive effects on Rs.

Variational Nested Dropout.

Nested dropout is a variant of dropout operation that is able to order network parameters or features based on the pre-defined importance during training. It has been explored for: I. Constructing nested nets Cui et al.

Antigen discovery for the development of cancer immunotherapy.

Central to successful cancer immunotherapy is effective T cell antitumor immunity. Multiple targeted immunotherapies engineered to invigorate T cell-driven antitumor immunity rely on identifying the repertoire of T cell antigens expressed on the tumor cell surface. Mass spectrometry-based survey of such antigens ("immunopeptidomics") combined with other omics platforms and computational algorithms has been instrumental in identifying and quantifying tumor-derived T cell antigens.

Association Analyses of Physical Fitness Parameters and Anxiety Symptoms in Chinese College Students.

Poor physical fitness is related to many negative health outcomes, including mental disorders. However, the relationship between physical fitness and anxiety symptoms among college students remains unclear. Therefore, this study investigated whether physical fitness is related to anxiety symptoms in Chinese college students.

Development of Serum-Free Media for Cryopreservation of Hydrogel Encapsulated Cell-Based Therapeutics.

Introduction: While hydrogel encapsulation of cells has been developed to treat multiple diseases, methods to cryopreserve and maintain the composite function of therapeutic encapsulated cell products are still needed to facilitate their storage and distribution. While methods to preserve encapsulated cells, and post-synthesis have received recent attention, effective preservation mediums have not been fully defined.

Methods: We employed a two-tiered screen of an initial library of 32 different cryopreservation agent (CPA) formulations composed of different cell-permeable and impermeable agents.

Duration of Daytime Napping Is Related to Physical Fitness among Chinese University Students.

Reportedly, daytime napping affects the physical fitness of athletes. However, results of these studies are conflicting, and may not be generalizable to all populations. Early adulthood is an important period linking adolescents and adults, during which building good physical fitness is crucial for their remaining lives.

Duration of Keeping an Exercise Habit and Mental Illness and Life Attitude among University Students.

Physical exercise has beneficial effects on human health, and several studies have examined the association between exercise and mental health. However, most of these studies focused on exercise intensity, duration, or frequency. Evidence for the association between the duration of maintaining an exercise habit and mental illness is lacking, especially in young adulthood-a crucial period that bridges adolescence and adulthood.

Association of Smartphone Use Duration with Physical Fitness among University Students: Focus on Strength and Flexibility.

High-frequency smartphone use leads to physical inactivity and may consequently cause the loss of physical fitness. Although the relationship between smartphone usage and physical fitness has been investigated, most of these studies focused on partial physical fitness, and the evaluation of the duration of smartphone use was insufficient. Therefore, this study aimed to investigate the relationship between the time period of using smart phones and physical fitness in Chinese university students.

Associations Between Consumption of Different Vegetable Types and Depressive Symptoms in Japanese Workers: A Cross-Sectional Study.

Purpose: Vegetable intake is an important part of our everyday diet and is associated with many positive health outcomes. Although previous studies have investigated the association between vegetable consumption and depressive symptoms among various populations, no study has examined this association in the adult working population. The present study investigated whether the frequency of consumption of a specific type of vegetable is associated with the prevalence of depressive symptoms in Japanese adult workers.

The association of sleep duration and quality with depressive symptoms in older Chinese women.

Poor sleep quality or short and long sleep duration are associated with many negative health outcomes, such as diabetes, hypertension, and fatigue, which may directly or indirectly correlate with poor mental health. Although, the association between sleep duration and quality, and depressive symptoms has been examined, the results of these studies were inconsistent and evidence specifically on older women is lacking. Therefore, we designed a cross-sectional study to evaluate the association between sleep duration and quality, and depressive symptoms in a relatively large sample of older Chinese women.

The Association of Smartphone Usage Duration with Physical Fitness among Chinese University Students.

Background: The use of smartphones has become increasingly prevalent in recent years, especially among the youth. However, smartphone overuse has been reported to be related to several negative mental and physical health outcomes. Although the association between smartphone use and physical fitness has been investigated in several studies, these studies only focused on specific elements of physical fitness, such as grip strength.

The IbBBX24-IbTOE3-IbPRX17 module enhances abiotic stress tolerance by scavenging reactive oxygen species in sweet potato.

Soil salinity and drought limit sweet potato yield. Scavenging of reactive oxygen species (ROS) by peroxidases (PRXs) is essential during plant stress responses, but how PRX expression is regulated under abiotic stress is not well understood. Here, we report that the B-box (BBX) family transcription factor IbBBX24 activates the expression of the class III peroxidase gene IbPRX17 by binding to its promoter.

Corrosion Resistance of Sulfur-Selenium Alloy Coatings.

Despite decades of research, metallic corrosion remains a long-standing challenge in many engineering applications. Specifically, designing a material that can resist corrosion both in abiotic as well as biotic environments remains elusive. Here a lightweight sulfur-selenium (S-Se) alloy is designed with high stiffness and ductility that can serve as an excellent corrosion-resistant coating with protection efficiency of ≈99.

The relationship between sunlight exposure duration and depressive symptoms: A cross-sectional study on elderly Chinese women.

Sunlight has been reported to have various beneficial effects on human health. Although research indicates an association between sunlight exposure and depressive symptoms, no study has examined it among the older adult population, especially among elderly Chinese women. This cross-sectional study addresses the aforesaid gap by investigating this association in 1,429 Chinese women aged 60 years and older.

Physical Exercise Behaviors and Depressive Symptoms Among Elderly Chinese Women: Focus on Exercise Components.

Purpose: Several studies have investigated the association between physical exercise and depressive symptoms in the elderly population. However, the relationship between components of physical exercise such as frequency, intensity, duration, and depressive symptoms remains unclear. This study was conducted on elderly Chinese women to investigate the association between each component of physical exercise and depressive symptoms and to examine the association between physical exercise patterns and depressive symptoms.

Accelerating Monte Carlo Bayesian Prediction via Approximating Predictive Uncertainty Over the Simplex.

Estimating the predictive uncertainty of a Bayesian learning model is critical in various decision-making problems, e.g., reinforcement learning, detecting the adversarial attack, self-driving car.

Association Between Parental Socioeconomic Status and Skeletal Muscle Mass in Chinese College Students: Fitness Improvement Tactics in Youths (FITYou) Project.

Purpose: The purpose of this study was to determine the association between parental socioeconomic status (SES) and skeletal muscle mass in Chinese college students.

Methods: A cross-sectional study including 2204 college freshmen was conducted in Shenyang, China. Data regarding body composition, health examinations, and a self-reported questionnaire were available from all the participants.

Intensity of Physical Activity and Depressive Symptoms in College Students: Fitness Improvement Tactics in Youth (FITYou) Project.

Purpose: To investigate whether the physical activity at different intensities is correlated with depressive symptoms in college students.

Patient And Methods: This cross-sectional study was a part of the Fitness Improvement Tactics in Youth Project, which was conducted in 2017. A total of 2,820 college freshmen aged 15-24 years were included in this study, of whom 699 (24.

Night-Eating Syndrome and Depressive Symptoms in College Freshmen: Fitness Improvement Tactics in Youths (FITYou) Project.

Background: Emerging evidence has shown that night-eating syndrome is correlated to depressive symptoms. However, these studies were mainly small-scale investigations.

Purpose: This study aimed to examine the association of night-eating syndrome with depressive symptoms among college students using a large-scale sample.