Whole transcriptome analysis in oviduct provides insight into microRNAs and ceRNA regulative networks that targeted reproduction of goat (Capra hircus).

Background: Reproduction traits are crucial for livestock breeding and represent key economic indicators in the domestic goat (Capra hircus) industry. The oviduct, a critical organ in female mammals, plays a pivotal role in several reproductive processes; however, its molecular mechanisms remain largely unknown. Non-coding RNA and mRNAs are essential regulatory elements in reproductive processes; yet their specific roles and regulatory networks in goat oviducts remain unclear.

Integrated analysis of differential expression profile of miRNA in the uterus of seasonal estrus sheep.

Background: Photoperiod is one of the important factors affecting seasonal estrus of sheep. The importance of the uterus to reproduction is self-evident. However, the uterine molecular mechanisms involved in photoperiodic regulation of seasonal estrus events in sheep remain poorly understood.

Esketamine attenuates traumatic brain injury by modulating STAT3-mediated Glycolysis and immune responses.

Background: Secondary injury following traumatic brain injury (TBI) involves neuroinflammation, immune cell infiltration, and metabolic dysregulation, leading to progressive neurological damage. This study evaluates the potential of esketamine, an NMDA receptor antagonist, to modulate immune responses, inhibit glycolysis, and mitigate secondary brain injury in a TBI mouse model.

Methods: Male C57BL/6J mice were subjected to controlled cortical impact to induce TBI.

Association between phthalate exposure and rash eczema disease: based on NHANES 2005-2006.

Phthalates are commonly found in plastic products, personal care products, and food packaging. In recent years, the relationship between phthalates and skin diseases such as eczema has been gaining attention. As endocrine disruptors, phthalates may increase the risk of eczema by affecting the immune system or skin barrier function.

A Comparative Study of Ultrasound and Thermal Processing: Effects on Stability and Protein Structure in Goat Milk.

Ultrasonic treatment has been shown to improve the functional properties and quality of proteins; however, the effect of ultrasound on the improvement of goat milk proteins and its impact on the quality of goat milk is not clear. In this study, we mainly want to analyze the effect of thermal stability of whole raw goat milk from the protein structural aspect and to analyze whole raw goat milk stability from the protein point of view. Goat milk was subjected to ultrasound treatments (400W/10 min, 500W/10 min, and 600W/10 min), while untreated and heat-treated samples served as controls.

A Reliable High-Performance Floating-Gate Transistor Based on ZrS Native Oxidation for Optoelectronic Synergistic Artificial Synapses.

Floating-gate transistors (FGTs), considered the most promising structure among three-terminal van der Waals (vdW) synaptic transistors, possess superiorities in improved data retention, excellent endurance properties, and multibit storage capacity, thereby overcoming the von Neumann bottleneck in conventional computing architectures. However, the dielectric layer in FGT devices typically depends on atomic layer deposition or mechanically transferred insulators, posing several challenges in terms of device compatibility, manufacturing complexity, and performance degradation. Therefore, it is crucial to discover dielectrics compatible with two-dimensional (2D) materials for further simplifying FGT structures and achieving optimal performance.

Dual-mode SPR/SERS optical fiber sensor for ultra-trace mercury ions detection.

The detection of mercury ions (Hg) is crucial due to its harmful effects on health and environment. In this article, what we believe to be a novel dual-mode optical fiber sensor incorporating surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) is proposed for ultra-trace Hg detection. The sensing probe comprises gold (Au)/graphene oxide (GO) composite membrane structure and Au nanospheres (AuNPs), which are connected via double-stranded DNA.

Dielectric-metal hybrid structured LSPR sensor based on graphene oxide amplification for lead ion detection.

The detection of lead ions (Pb) is crucial due to its harmful effects on health and the environment. In this article, what we believe to be a novel dielectric-metal hybrid structure localized surface plasmon resonance (LSPR) sensor for ultra-trace detection of Pb is proposed, featuring a zinc sulfide layer, silver nanodisks (Ag-disks), and graphene oxide (GO) covering the Ag-disks. The sensor works by detecting the variation of gold nanoparticles (AuNPs) on its surface when Pb cleaves a substrate strand linked to a DNAzyme, causing the AuNPs modified on the substrate strand to disperse.

Evaluation of the recovery effects of antibiotic-resistant Lactiplantibacillus plantarum subsp. plantarum ATCC14917 on the antibiotic-disturbed intestinal microbiota using a mice model.

Aims: Supplementing Lactobacillus alongside antibiotic treatment was a curative strategy to modulate gut microbiota and alleviate antibiotic-associated dysbiosis. But the lactobacilli that are used as probiotics are sensitive or have a low level of resistance to antibiotics, so they usually cannot achieve their beneficial effect, since they are killed by the applied antibiotics. This work aimed to develop the highly resistant Lactiplantibacillus plantarum subsp.

Uncovering the Heterogeneity of Signaling Pathways in Skin Cutaneous Melanoma: Insights into Prognostic Values and Immune Interactions.

Background: Signaling pathways play crucial roles in tumor cells. However, functional heterogeneity of signaling pathways in skin cutaneous melanoma (SKCM) has not been established.

Methods: Based on a recent computational pipeline, pathway activities between SKCM and normal samples were identified.

Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18.

Background: Myoblasts serve as the fundamental building blocks of muscle fibers, and there is a positive correlation between the diameter of myofibers during the juvenile phase and the rate of muscle growth, which does not change in adulthood. However, the molecular mechanisms governing myofiber diameter across various developmental stages in goats remain largely unclear.

Results: In this study, we examined miRNA expression in the longissimus dorsi muscle tissue of goats at two distinct ages: one month, a period characterized by robust muscle growth, and nine months, when muscle development plateaus in adulthood.

The association between dietary diversity and patterns in Chinese university students with abnormal uterine bleeding: a cross-sectional study.

Background: Abnormal uterine bleeding (AUB) is a common gynecological issue during reproductive years. Researches on how dietary diversity and patterns influence AUB in Chinese university students are limited, with some studies not clearly defining irregular menstruation. This research investigated the incidence of AUB according to the International Federation of Gynecology and Obstetrics criteria and sought to identify preventative factors via online questionnaires.

Real-time spectroscopic tracking of efficient intersystem crossing triggered by the heavy-atom effect in di-heteroatomic organic phosphorescent molecules.

The development of efficient and long-lived halogen-free organic phosphorescent molecules remains a challenge. For the single-heteroatomic 9,10-dihydroacridine (AcH), the evolution of singlet and triplet excited state absorption signals reveals an intersystem crossing (ISC) lifetime of 8.2 ns and a triplet state lifetime of 0.

Effective promotion of steric hindrance effect on singlet-triplet transition of para-linked carbazole-biphenyl by transient absorption spectroscopy.

The para-linked carbazole-biphenyl (CBP) is commonly utilized in phosphorescent organic light-emitting diodes. This study investigates the steric hindrance and heavy-atom effects in CBP derivatives through transient absorption spectroscopy. In contrast to CBP, CBP derivatives shows new triplet-triplet absorption signals and isosbestic points, accompanied by the decay of excited state absorption signal, which indicates the occurrence of intersystem crossing (ISC).

Graphene-enhanced dielectric-metal hybrid structure for high performance LSPR sensing.

In this paper, we introduce what we believe to be a novel hybrid localized surface plasmonic resonance (LSPR) sensing structure that integrates silver nanodisks (Ag-disks), a zinc sulfide (ZnS) layer, and two-dimensional graphene material as a critical intermediary. By exciting the LSPR between the Ag-disks and the surface of the ZnS film, two sensing channels can be achieved in visible spectra. The sensing performance of the proposed sensor is experimentally investigated from two aspects: bulk refractive index and surface sensitivities.

Generation of arbitrary vector orbital angular momentum beams on higher-order Poincaré spheres based on an all-dielectric metasurface with complex amplitude modulation.

Vector orbital angular momentum (OAM) beams, described by higher-order Poincaré (HOP) sphere, are generalized forms of waves carrying OAM with an inhomogeneous polarization of wavefronts. We construct all-dielectric metasurfaces with adjustable amplitude, polarization, and phase to generate arbitrary vector OAM beams. The metasurface is composed of two pairs of silicon nanopillars arranged alternately.

Comparative Efficacy and Safety of Anesthetic and Sedative Regimens for Endoscopic Retrograde Cholangiopancreatography: A Network Meta-Analysis.

Introduction: This study evaluates the efficacy and safety of various anesthetic and sedative regimens for endoscopic retrograde cholangiopancreatography (ERCP) procedures.

Methods: A systematic search was conducted across PubMed, Web of Science, Scopus, and Embase to identify randomized controlled trials (RCTs) published until March 2024. Primary outcomes included procedure time, patient satisfaction, oxygen saturation (SpO2), incidence of SpO2 below 90%, and adverse events.

miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52.

In Brief: Steroid hormone secretion by granulosa cells in the ovary is regulated by lipid synthesis and metabolism. This study found that miR-novel-216 affects granulosa cell proliferation and free fatty acid content by regulating TPD52 expression, thereby increasing the reproductive hormone secretion and promoting polytocous trait in goats.

Abstract: Granulosa cells in the ovaries of livestock are crucial for secreting steroid hormones that regulate follicular development, with lipid synthesis and metabolism playing key roles in this process.

Managing Edge States in Reduced-Dimensional Perovskites for Highly Efficient Deep-Blue LEDs.

Pure-halide reduced-dimensional perovskites, featuring large exciton binding energy and tunable bandgap, show great potential for high-efficiency deep-blue perovskite light-emitting diodes (PeLEDs). However, their efficiency, particularly in the low n-value phase domain ("n" represents the number of octahedral sheets), lags behind analogous perovskite emitters. Herein, it is demonstrated that the vibration of edge-dangling octahedra in the low n-value phase activates notorious exciton-phonon (EP) coupling, thereby deteriorating efficiency.

SSA-ZP on Scalp Seborrheic Dermatitis: Regulating Sebum Levels and Scalp Barrier.

Background: The occurrence of scalp seborrheic dermatitis (SD) is closely related to the production of sebum and scalp barrier function. Supramolecular salicylic acid has the keratolytic and anti-inflammatory properties, and zinc pyrithione is an antifungal drug delivered as a microparticle to skin epithelia.

Objective: This study aimed to assess the efficacy and safety of 2% supramolecular salicylic acid (SSA) combined with 0.

Accurately Measuring the Infrared Spectral Emissivity of Inconel 601, Inconel 625, and Inconel 718 Alloys during the Oxidation Process.

Accurate measurement of the infrared spectral emissivity of nickel-based alloys is significant for applications in aerospace. The low thermal conductivity of these alloys limits the accuracy of direct emissivity measurement, especially during the oxidation process. To improve measurement accuracy, a surface temperature correction method based on two thermocouples was proposed to eliminate the effect of thermal conductivity changes on emissivity measurement.

Theoretical Investigation on Proton Transfer Directionality and Dynamics Behavior of 3-(Benzo[]thiazol-2-yl)-2-hydroxy-5-methoxybenzaldehyde with Two Asymmetric Proton Acceptors.

A detailed theoretical investigation on the excited state intramolecular proton transfer (ESIPT) directionality and dynamics behavior of 3-(benzo[]thiazol-2-yl)-2-hydroxy-5-methoxybenzaldehyde (BTHMB) with two unsymmetric proton acceptors (N and O) has been performed. The hydrogen bond O-H···N in BTHMB-a formed by the O-H group with the N atom or O-H···O in BTHMB-b formed by the O-H group with the O atom is enhanced upon photoexcitation, and the strength of the O-H···N bond is stronger, which will drive the O-H proton to the N atom. Potential energy curves further confirm that ESIPT occurs in the N atom because of the smaller energy barrier (0.

Multimodal Management of Ruptured Internal Carotid Artery Blood Blister-like Aneurysm: Technical Notes and Case Series of Surgical Muscle Wrapping and Fenestration Clipping Combined with Flow-Diverter Embolization.

Objective: To evaluate the effects of a multimodal management technique combining surgical muscle wrapping, clipping, and flow-diverter stent (FDS) placement in patients with ruptured blood blister-like aneurysms (BBAs) in the internal carotid artery (ICA).

Methods: In a retrospective case series review from 2020 to 2023, 3 patients with ruptured ICA BBAs underwent multimodal management, an approach combining muscle wrapping, surgical clipping, and FDS embolization. The aneurysm sac was initially packed and wrapped with multiple tailored temporalis muscle grafts and then secured using fenestration clips, with good preservation of the ICA branches.

Multispectral radiation thermometry platform based on wireless data transmission.

In metal smelting, precise temperature control is of vital importance for reaction rates, efficiency, and product quality. Traditional methods such as thermocouples have inherent limitations, but multispectral radiation thermometry (MRT) offers high resolution and reliability. This paper proposes a multispectral radiation thermometry platform featuring wireless data transmission, which enables remote data transfer and precise temperature measurements.