Publications by authors named "Yufan Fred Wu"
Article Synopsis
- UHDR radiation therapy shows potential in reducing toxicity while maintaining effective tumor control compared to conventional methods.
- The study successfully modified a decommissioned clinical LINAC to deliver UHDR electron treatments without significant hardware changes, utilizing respiratory gating for pulse delivery.
- Results demonstrated that UHDR setups provided consistent dose rates across various field sizes and depths, indicating practical feasibility for broader clinical applications.
Purpose/Objectives Combination BRAF (vemurafenib, dabrafenib, or encorafenib) plus MEK (trametinib, cobimetinib, or binimetinib) inhibitor therapy is now widely used in the treatment of metastatic melanoma. However, data for intracranial response to these drugs are limited. We aimed to evaluate the intracranial efficacy of BRAF plus MEK inhibitors in patients with BRAF-mutant melanoma with brain metastases (BM) and to determine patterns of failure of these new agents to inform optimal integration of local intracranial therapy.
View Article and Find Full Text PDFBackground And Purpose: We describe a multicenter cross validation of ultra-high dose rate (UHDR) (>= 40 Gy/s) irradiation in order to bring a dosimetric consensus in absorbed dose to water. UHDR refers to dose rates over 100-1000 times those of conventional clinical beams. UHDR irradiations have been a topic of intense investigation as they have been reported to induce the FLASH effect in which normal tissues exhibit reduced toxicity relative to conventional dose rates.
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