Publications by authors named "Yuezhen Huang"
Article Synopsis
- The oral cavity harbors a vast population of bacteria, and emerging evidence links periodontal disease to Alzheimer's disease (AD) through inflammation and the gut-brain axis.
- Researchers studied how saliva from periodontitis patients affects cognitive function and AD pathology in transgenic mice, finding that such saliva worsens cognitive decline and increases harmful brain proteins.
- The findings suggest that periodontitis-related bacteria contribute to AD progression by disrupting gut health and promoting systemic inflammation, offering new insights into potential interventions for AD.
Salivary microbiota of periodontitis aggravates bone loss in ovariectomized rats.
Front Cell Infect Microbiol
August 2022
The mechanisms underlying the crosstalk between periodontitis and osteoporosis remain unclear. Recently, the gut microbiota has been recognized as a pivotal regulator of bone metabolism, and oral and gut mucosae are microbiologically connected. In this study, we investigated the effects of periodontitis on osteoporosis through the oral-gut axis.
View Article and Find Full Text PDFAim: To investigate whether periodontitis impacts bone homeostasis via gut microbiota regulation.
Materials And Methods: Experimental periodontitis was induced by ligatures (LIG group). ApoE mice were employed as a model with weakened bone homeostasis.
Periodontitis has been associated with a variety of systematic diseases via affecting gut microbiota. However, the influence of periodontal treatment on intestinal microbiota is not known. Hyperlipidemia can significantly alter gut microbiota structure.
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