Publications by authors named "Yuezhang Ma"
T Cells Trafficking into the Brain in Aging and Alzheimer's Disease.
J Neuroimmune Pharmacol
August 2024
Article Synopsis
- - The meninges, choroid plexus, and blood-brain barrier are crucial in allowing peripheral immune cells to enter the central nervous system, particularly during aging and Alzheimer's disease (AD).
- - The paper reviews recent findings on how T cells are recruited to the brain, exploring their entry pathways and interactions with resident brain cells, which can contribute to brain injury.
- - Understanding these mechanisms may lead to better insights into aging and AD, potentially paving the way for new treatment strategies targeting immune cell involvement.
The gut microbiota and neurological development of neonatal mice are susceptible to environmental factors that may lead to altered behavior into adulthood. However, the role that changed gut microbiota and neurodevelopment early in life play in this needs to be clarified. In this study, by modeling early-life environmental changes by cross-fostering BALB/c mice, we revealed the effects of the environment during the critical period of postnatal development on adult social behavior and their relationship with the gut microbiota and the nervous system.
View Article and Find Full Text PDFIntroduction: Transcription factor EB (TFEB), a key regulator of autophagy and lysosomal biogenesis, has diverse roles in various physiological processes. Enhancing lysosomal function by TFEB activation has recently been implicated in restoring neural stem cells (NSCs) function. Overexpression of TFEB can inhibit the cell cycle of newborn cortical NSCs.
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- High salt diet (HSD) is linked to hypertension and cardiovascular diseases, and while its connection to Alzheimer's disease (AD) isn't fully clear, animal studies reveal it can worsen tau protein issues and cognitive function.
- In experiments with APP/PS1 mice (AD model) and regular mice on a HSD, results showed increased tau hyperphosphorylation and worsened Aβ42 deposition specifically in the APP/PS1 mice brains.
- HSD led to changes like microglia proliferation, altered blood-brain barrier permeability, and cognitive decline in both mouse types, suggesting HSD may induce and exacerbate Alzheimer's-like conditions through tau protein issues and neurovascular unit dysfunction.
According to many in the field，the prevalence of Alzheimer's disease (AD) in type II diabetes (T2DM) populations is considerably higher than that in the normal population. Human islet amyloid polypeptide (hIAPP) is considered to be a common risk factor for T2DM and AD. Preliminary observations around T2DM animal model show that the decrease of adult neural stem cells (NSCs) in the subventricular zone (SVZ) is accompanied by olfactory dysfunction.
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