The Burden of Severe Periodontitis in China From 1990 to 2021, With Projections to 2050: A Comprehensive Analysis From The Global Burden of Disease Study 2021.

Background: The study aims to explore the epidemiologic information related to severe periodontitis in China.

Methods: We analyzed data from the Global Burden of Disease (GBD) 2021 study to delineate the incidence, prevalence, and disability-adjusted life years (DALYs) attributable to severe periodontitis in China, stratified by age and gender. A range of analytical methods, including comparative analysis, trend analysis, decomposition analysis, hierarchical cluster analysis, health inequality analysis, and predictive modeling, were employed to provide a comprehensive evaluation of the disease burden.

Artificial intelligence in the diagnosis of dental diseases on panoramic radiographs: a preliminary study.

Background: Artificial intelligence (AI) has been introduced to interpret the panoramic radiographs (PRs). The aim of this study was to develop an AI framework to diagnose multiple dental diseases on PRs, and to initially evaluate its performance.

Methods: The AI framework was developed based on 2 deep convolutional neural networks (CNNs), BDU-Net and nnU-Net.

Computer-designed surgical templates improve the extraction of impacted supernumerary teeth in the hard palate.

Objectives: The surgical procedure of bony impacted supernumerary teeth (SNT) in hard palate is commonly done with poor visualization and uncomfortable posture. This study aims to introduce our primary practice of presurgical evaluation and guiding exodontia of bony impacted supernumerary teeth (SNT) in the hard palate to reduce surgical trauma, duration and uncertainty.

Study Design: Twelve patients with impacted supernumerary teeth in hard palate were included.

pH-responsive aminotriazole doped metal organic frameworks nanoplatform enables self-boosting reactive oxygen species generation through regulating the activity of catalase for targeted chemo/chemodynamic combination therapy.

The rational integration of chemotherapy and hydroxyl radical (·OH)-mediated chemodynamic therapy (CDT) via functional metal-organic frameworks (MOF) carriers has great potential in cancer therapy. In this work, aminotriazole (3-AT) doped polyhedral metal organic frameworks (denoted as MAF) were prepared by template ligand replacement, where CDT was initiated by Cu/Cu modulated Fenton reaction and enhanced by effectively regulating the catalase activity with 3-AT. However, a rod-like Cu-MOF with 3-AT served as a ligand was obtained by the hydrothermal method without using template.

A Supramolecular Photosensitizer System Based on Nano-Cu/ZIF-8 Capped with Water-Soluble Pillar[6]arene and Methylene Blue Host-Guest Complexations.

Photodynamic therapy (PDT) as a safe, non-invasive modality for cancer therapy, in which the low oxygen and high glutathione in the tumor microenvironment reduces therapeutic efficiency. In order to overcome these problems, we prepared a supramolecular photosensitive system of O-Cu/ZIF-8@ZIF-8@WP6-MB (OCZWM), which was loaded with oxygen to increase the oxygen concentration in the tumor microenvironment, and the Cu in the system reacted with glutathione (GSH) to reduce the GSH concentration to generate Cu. It is worth noting that the generated Cu can produce the Fenton reaction, thus realizing the combination therapy of PDT and chemodynamic therapy (CDT) to achieve the purpose of significantly improving the anti-cancer efficiency.

Lycium ruthenicum Murr. alleviates nonalcoholic fatty liver in mice.

Oxidative stress and inflammation contribute to hypertriglyceridemia-induced nonalcoholic fatty liver disease (NAFLD). Cholesterol-enriched diets increase the risk of NAFLD. Murr.

Ilex latifolia Thunb protects mice from HFD-induced body weight gain.

Kuding tea is implicated in alleviating metabolic disorders in traditional Chinese medicine. However, the role of Ilex latifolia Thunb (kuding tea), one of the large leaf kuding tea species, in the prevention of the development of obesity remains to be determined. We show here that 7-week-old male mice treated with an Ilex latifolia Thunb supplement for 14 weeks were resistant to HFD-induced body weight gain and hepatic steatosis, accompanied by improved insulin sensitivity.

Seasonal responses of soil respiration to warming and nitrogen addition in a semi-arid alfalfa-pasture of the Loess Plateau, China.

Responses of soil respiration (R) to increasing nitrogen (N) deposition and warming will have far-reaching influences on global carbon (C) cycling. However, the seasonal (growing and non-growing seasons) difference of R responses to warming and N deposition has rarely been investigated. We conducted a field manipulative experiment in a semi-arid alfalfa-pasture of northwest China to evaluate the response of R to nitrogen addition and warming from March 2014 to March 2016.

Low-Grade Myofibroblastic Sarcoma in the Mandibular Canal: A Case Report.

Low-grade myofibroblastic sarcoma (LGMS) represents an atypical myofibroblastic tumor characterized by a diffusely infiltrating pattern of spindle-shaped tumor cells. It was classified as a distinct soft tissue tumor by the World Health Organization in 2002. LGMS occurs mostly in adult patients and has a predilection for the head and neck region.

[A study of repairing mandibular defect using tissue engineering bone with bone marrow stem cells cell sheets in dog].

Objective: To reconstruct mandibular defect using tissue engineering bone with bone marrow stem cells (BMSCs) cell sheets and investigate the effect of cell sheets on osteogenesis.

Methods: BMSCs were isolated with the method of density gradient centrifugation from canine and cultured. BMSCs were induced to differentiate to osteoblasts.