Noise-assisted hybrid attention networks for low-dose PET and CT denoising.

Background: Positron emission tomography (PET) and computed tomography (CT) play a vital role in tumor-related medical diagnosis, assessment, and treatment planning. However, full-dose PET and CT pose the risk of excessive radiation exposure to patients, whereas low-dose images compromise image quality, impacting subsequent tumor recognition and disease diagnosis.

Purpose: To solve such problems, we propose a Noise-Assisted Hybrid Attention Network (NAHANet) to reconstruct full-dose PET and CT images from low-dose PET (LDPET) and CT (LDCT) images to reduce patient radiation risks while ensuring the performance of subsequent tumor recognition.

Quasi-supervised learning for super-resolution PET.

Low resolution of positron emission tomography (PET) limits its diagnostic performance. Deep learning has been successfully applied to achieve super-resolution PET. However, commonly used supervised learning methods in this context require many pairs of low- and high-resolution (LR and HR) PET images.

Multi-modal tumor segmentation methods based on deep learning: a narrative review.

Background And Objective: Automatic tumor segmentation is a critical component in clinical diagnosis and treatment. Although single-modal imaging provides useful information, multi-modal imaging provides a more comprehensive understanding of the tumor. Multi-modal tumor segmentation has been an essential topic in medical image processing.

QS-ADN: quasi-supervised artifact disentanglement network for low-dose CT image denoising by local similarity among unpaired data.

Deep learning has been successfully applied to low-dose CT (LDCT) image denoising for reducing potential radiation risk. However, the widely reported supervised LDCT denoising networks require a training set of paired images, which is expensive to obtain and cannot be perfectly simulated. Unsupervised learning utilizes unpaired data and is highly desirable for LDCT denoising.

3D PET/CT tumor segmentation based on nnU-Net with GCN refinement.

. Whole-body positron emission tomography/computed tomography (PET/CT) scans are an important tool for diagnosing various malignancies (e.g.

Abnormal functional connectivity density involvement in freezing of gait and its application for subtyping Parkinson's disease.

The pathophysiological mechanisms at work in Parkinson's disease (PD) patients with freezing of gait (FOG) remain poorly understood. Functional connectivity density (FCD) could provide an unbiased way to analyse connectivity across the brain. In this study, a total of 23 PD patients with FOG (PD FOG + patients), 26 PD patients without FOG (PD FOG- patients), and 22 healthy controls (HCs) were recruited, and their resting-state functional magnetic resonance imaging (rs-fMRI) images were collected.

EMDS-7: Environmental microorganism image dataset seventh version for multiple object detection evaluation.

Nowadays, the detection of environmental microorganism indicators is essential for us to assess the degree of pollution, but the traditional detection methods consume a lot of manpower and material resources. Therefore, it is necessary for us to make microbial data sets to be used in artificial intelligence. The Environmental Microorganism Image Dataset Seventh Version (EMDS-7) is a microscopic image data set that is applied in the field of multi-object detection of artificial intelligence.

Aberrant degree centrality of functional brain networks in subclinical depression and major depressive disorder.

Background: As one of the most common diseases, major depressive disorder (MDD) has a significant adverse impact on the li of patients. As a mild form of depression, subclinical depression (SD) serves as an indicator of progression to MDD. This study analyzed the degree centrality (DC) for MDD, SD, and healthy control (HC) groups and identified the brain regions with DC alterations.

EBHI-Seg: A novel enteroscope biopsy histopathological hematoxylin and eosin image dataset for image segmentation tasks.

Background And Purpose: Colorectal cancer is a common fatal malignancy, the fourth most common cancer in men, and the third most common cancer in women worldwide. Timely detection of cancer in its early stages is essential for treating the disease. Currently, there is a lack of datasets for histopathological image segmentation of colorectal cancer, which often hampers the assessment accuracy when computer technology is used to aid in diagnosis.

Iterator-Net: sinogram-based CT image reconstruction.

Image reconstruction is extremely important for computed tomography (CT) imaging, so it is significant to be continuously improved. The unfolding dynamics method combines a deep learning model with a traditional iterative algorithm. It is interpretable and has a fast reconstruction speed, but the essence of the algorithm is to replace the approximation operator in the optimization objective with a learning operator in the form of a convolutional neural network.

Improving the level of autism discrimination with augmented data by GraphRNN.

Datasets are the key to deep learning in autism disease research. However, due to the small quantity and heterogeneity of samples in current public datasets, for example Autism Brain Imaging Data Exchange (ABIDE), the recognition research is not sufficiently effective. Previous studies primarily focused on optimizing feature selection methods and data augmentation to improve recognition accuracy.

Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder.

Background: Major depressive disorder (MDD) is a common cause of disability and morbidity, affecting about 10% of the population worldwide. Subclinical depression (SD) can be understood as a precursor of MDD, and therefore provides an MDD risk indicator. The pathogenesis of MDD and SD in humans is still unclear, and the current diagnosis lacks accurate biomarkers and gold standards.

A comprehensive survey on deep learning techniques in CT image quality improvement.

High-quality computed tomography (CT) images are key to clinical diagnosis. However, the current quality of an image is limited by reconstruction algorithms and other factors and still needs to be improved. When using CT, a large quantity of imaging data, including intermediate data and final images, that can reflect important physical processes in a statistical sense are accumulated.

Structural Brain Network Abnormalities in Parkinson's Disease With Freezing of Gait.

Objective: Diffusion tensor imaging (DTI) studies have investigated white matter (WM) integrity abnormalities in Parkinson's disease (PD). However, little is known about the topological changes in the brain network. This study aims to reveal these changes by comparing PD without freezing of gait (FOG) (PD FOG-), PD with FOG (PD FOG+), and healthy control (HC).

An Entropy Weighted Nonnegative Matrix Factorization Algorithm for Feature Representation.

Nonnegative matrix factorization (NMF) has been widely used to learn low-dimensional representations of data. However, NMF pays the same attention to all attributes of a data point, which inevitably leads to inaccurate representations. For example, in a human-face dataset, if an image contains a hat on a head, the hat should be removed or the importance of its corresponding attributes should be decreased during matrix factorization.

Parameter-Transferred Wasserstein Generative Adversarial Network (PT-WGAN) for Low-Dose PET Image Denoising.

Due to the widespread use of positron emission tomography (PET) in clinical practice, the potential risk of PET-associated radiation dose to patients needs to be minimized. However, with the reduction in the radiation dose, the resultant images may suffer from noise and artifacts that compromise diagnostic performance. In this paper, we propose a parameter-transferred Wasserstein generative adversarial network (PT-WGAN) for low-dose PET image denoising.

Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study.

Freezing of gait (FOG) in Parkinson's disease (PD) leads to devastating consequences; however, little is known about its functional brain network. We explored the differences in degree centrality (DC) of functional networks among PD with FOG (PD FOG+), PD without FOG (PD FOG-), and healthy control (HC) groups. In all, 24 PD FOG+, 37 PD FOG-, and 22 HCs were recruited and their resting-state functional magnetic imaging images were acquired.

Integrating Structural and Functional Interhemispheric Brain Connectivity of Gait Freezing in Parkinson's Disease.

Freezing of gait (FOG) has devastating consequences for patients with Parkinson's disease (PD), but the underlying pathophysiological mechanism is unclear. This was investigated in the present study by integrated structural and functional connectivity analyses of PD patients with or without FOG (PD FOG+ and PD FOG-, respectively) and healthy control (HC) subjects. We performed resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging of 24 PD FOG+ patients, 37 PD FOG- patients, and 24 HCs.

LCPR-Net: low-count PET image reconstruction using the domain transform and cycle-consistent generative adversarial networks.

Background: Reducing the radiation tracer dose and scanning time during positron emission tomography (PET) imaging can reduce the cost of the tracer, reduce motion artifacts, and increase the efficiency of the scanner. However, the reconstructed images to be noisy. It is very important to reconstruct high-quality images with low-count (LC) data.

Less Is Better: Single-Digit Brain Functional Connections Predict T2DM and T2DM-Induced Cognitive Impairment.

Type 2 diabetes mellitus (T2DM) leads to a higher risk of brain damage and adversely affects cognition. The underlying neural mechanism of T2DM-induced cognitive impairment (T2DM-CI) remains unclear. This study proposes to identify a small number of dysfunctional brain connections as imaging biomarkers, distinguishing between T2DM-CI, T2DM with normal cognition (T2DM-NC), and healthy controls (HC).

[Brain functional network reconstruction based on compressed sensing and fast iterative shrinkage-thresholding algorithm].

The construction of brain functional network based on resting-state functional magnetic resonance imaging (fMRI) is an effective method to reveal the mechanism of human brain operation, but the common brain functional network generally contains a lot of noise, which leads to wrong analysis results. In this paper, the least absolute shrinkage and selection operator (LASSO) model in compressed sensing is used to reconstruct the brain functional network. This model uses the sparsity of -norm penalty term to avoid over fitting problem.

Predicting Unnecessary Nodule Biopsies from a Small, Unbalanced, and Pathologically Proven Dataset by Transfer Learning.

This study explores an automatic diagnosis method to predict unnecessary nodule biopsy from a small, unbalanced, and pathologically proven database. The automatic diagnosis method is based on a convolutional neural network (CNN) model. Because of the small and unbalanced samples, the presented method aims to improve the transfer learning capability via the VGG16 architecture and optimize the related transfer learning parameters.

Quadratic Autoencoder (Q-AE) for Low-Dose CT Denoising.

Inspired by complexity and diversity of biological neurons, our group proposed quadratic neurons by replacing the inner product in current artificial neurons with a quadratic operation on input data, thereby enhancing the capability of an individual neuron. Along this direction, we are motivated to evaluate the power of quadratic neurons in popular network architectures, simulating human-like learning in the form of "quadratic-neuron-based deep learning". Our prior theoretical studies have shown important merits of quadratic neurons and networks in representation, efficiency, and interpretability.

Connectome-Based Biomarkers Predict Subclinical Depression and Identify Abnormal Brain Connections With the Lateral Habenula and Thalamus.

Subclinical depression (SD) has been considered as the precursor to major depressive disorder. Accurate prediction of SD and identification of its etiological origin are urgent. Bursts within the lateral habenula (LHb) drive depression in rats, but whether dysfunctional LHb is associated with SD in human is unknown.

Segmentation of lung parenchyma in CT images using CNN trained with the clustering algorithm generated dataset.

Background: Lung segmentation constitutes a critical procedure for any clinical-decision supporting system aimed to improve the early diagnosis and treatment of lung diseases. Abnormal lungs mainly include lung parenchyma with commonalities on CT images across subjects, diseases and CT scanners, and lung lesions presenting various appearances. Segmentation of lung parenchyma can help locate and analyze the neighboring lesions, but is not well studied in the framework of machine learning.