Publications by authors named "Yuexuan Shi"
Article Synopsis
- The immune system is essential for regulating body functions and consists of various immune cells, organs, and signaling factors, but it experiences decline as a person ages, known as 'immune aging.'
- Aging leads to negative changes in immune cell function, such as poorer neutrophil movement and reduced macrophage activity, resulting in inadequate responses to infections, vaccinations, and an increased risk of autoimmune disorders.
- Immune aging affects not just individual cells but also organs like bone marrow and the thymus, contributing to chronic inflammation and higher chances of developing age-related diseases like Alzheimer's and osteoporosis, prompting the need for research into potential anti-aging strategies targeting immune function.
Insights into the epitranscriptomic role of N-methyladenosine on aging skeletal muscle.
Biomed Pharmacother
August 2024
The modification of RNA through the N6-methyladenosine (m6A) has emerged as a growing area of research due to its regulatory role in gene expression and various biological processes regulating the expression of genes. m6A RNA methylation is a post-transcriptional modification that is dynamic and reversible and found in mRNA, tRNA, rRNA, and other non-coding RNA of most eukaryotic cells. It is executed by special proteins known as "writers," which initiate methylation; "erasers," which remove methylation; and "readers," which recognize it and regulate the expression of the gene.
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