PD-1 expression on uveal melanoma induces tumor proliferation and predicts poor patient survival.

Introduction: Uveal melanoma is one of the most common primary intraocular malignant tumors with poor prognosis and limited treatments. Programmed cell death receptor-1 (PD-1) blockade represents the primary treatment strategy of immune checkpoint inhibition; however, there is a lack of studies on whether PD-1 expression in primary (ocular) uveal melanoma affects tumor progression.

Methods: PD-1 expression in 82 cases of primary (ocular) uveal melanoma was detected by immunohistochemistry.

Knockdown of LINC01694 inhibits growth of gallbladder cancer cells via miR-340-5p/Sox4.

Purpose: The indispensable role of long non-coding RNAs (lncRNAs) in tumorigenesis has been increasingly reported. In the present study, LINC01694 was found to regulate the proliferation, invasion, as well as apoptosis in gallbladder cancer (GBC) cells through sponging miR-340-5p.

Methods: LINC01694 level in GBC cells was quantified by quantitative real-time polymerase chain reaction (qRT-PCR).

Temperature Dependence of Anisotropic Thermal-Conductivity Tensor of Bulk Black Phosphorus.

The anisotropic thermal-conductivity tensor of bulk black phosphorus (BP) for 80 ≤T ≤ 300 K is reported. Despite the anisotropy, phonons are predominantly scattered by Umklapp processes in all the crystallographic orientations. It is also found that the phonon mean-free-paths of BP are rather long (up to 1 µm) in the through-plane direction.