Mechanism of Chemically Induced Structural Evolution of Lead Azide under Hygrothermal Condition.

Aging behavior of pyrotechnic agents is a serious threat to the reliability of the practical application of pyrotechnic products, while multiple environmental factors make it challenging to characterize the aging mechanism of pyrotechnic agents. This paper explored the aging process of LA in four hygrothermal environments with morphology and structure analysis techniques. LA aging underwent three stages: rapid surface reaction with HO and CO, interior hydrolysis by HO, and CO reaction with lead oxides.

Nomogram for predicting proliferative lupus nephritis in patients with low-level proteinuria.

Objectives: Proliferative lupus nephritis (LN) is not uncommon in individuals with proteinuria < 0.5 g/24h, highlighting the importance of predicting proliferative nephritis for effective clinical management. We aimed to develop a predictive model for proliferative nephritis in this population.

Identifying subgroups benefiting from intensive glycaemic treatment to improve renal outcomes in type 2 diabetes: Insights from the ACCORD trial.

Aims: The ACCORD trial showed that intensive glucose-lowering therapy has a limited impact on renal function decline. We aimed to identify subgroups in the ACCORD population that might derive renal benefits from intensive glucose-lowering therapy.

Materials And Methods: The primary renal outcome included a ≥50% decline in baseline estimated glomerular filtration rate or end-stage renal disease (ESRD).

Targeted therapies for lupus nephritis: Current perspectives and future directions.

Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus, poses a substantial risk of progression to end-stage renal disease, with increased mortality. Conventional therapy for LN relies on broad-spectrum immunosuppressants such as glucocorticoids, mycophenolate mofetil, and calcineurin inhibitors. Although therapeutic regimens have evolved over the years, they have inherent limitations, including non-specific targeting, substantial adverse effects, high relapse rates, and prolonged maintenance and remission courses.

Clinicopathological characteristics and outcomes of lupus nephritis patients with scanty immune depositions in kidney biopsies.

Background: The clinicopathological features, outcomes, and pathogenesis of lupus nephritis with scanty immune deposits in the kidney biopsy remain unclear.

Methods: Four hundred ninety-eight biopsy-proven lupus nephritis patients were included, and clinical and pathological data were collected. The primary endpoint was mortality, while the secondary endpoint was doubling baseline serum creatinine or end-stage renal disease.

[Analysis of related factors between sudden sensorineural hearing loss and serum indices base on artificial intelligence and big data].

The etiology and pathophysiologic mechanism of sudden sensorineural hearing loss are undefined. We will use artificial intelligence and big data methods to explore the correlation between sudden sensorineural hearing loss and serum indices. A total of 1218 patients with sudden deafness admitted to Sun Yat-sen Memorial Hospital were selected as the experimental group, 95 861 healthy subjects were randomly selected as the control group at the same period.

Comparison of 2 Ear Molding Systems for Nonsurgical Management of Newborn Auricular Deformities.

Background: Congenital auricular deformities are common diseases in newborn infants. We compared the efficacy of 2 ear molding systems in the nonsurgical management of newborn auricular deformities in Chinese infants.

Methods: A total of 462 newborns with auricular deformities were treated with either the EarWell or the LiangEar ear molding systems.

Computer-aided diagnosis of laryngeal cancer via deep learning based on laryngoscopic images.

Objective: To develop a deep convolutional neural network (DCNN) that can automatically detect laryngeal cancer (LCA) in laryngoscopic images.

Methods: A DCNN-based diagnostic system was constructed and trained using 13,721 laryngoscopic images of LCA, precancerous laryngeal lesions (PRELCA), benign laryngeal tumors (BLT) and normal tissues (NORM) from 2 tertiary hospitals in China, including 2293 from 206 LCA subjects, 1807 from 203 PRELCA subjects, 6448 from 774 BLT subjects and 3191 from 633 NORM subjects. An independent test set of 1176 laryngoscopic images from other 3 tertiary hospitals in China, including 132 from 44 LCA subjects, 129 from 43 PRELCA subjects, 504 from 168 BLT subjects and 411 from 137 NORM subjects, was applied to the constructed DCNN to evaluate its performance against experienced endoscopists.

Synthesis, Characterization, and Sensitivity of a CL-20/PNCB Spherical Composite for Security.

Highly energetic materials have received significant attention, particularly 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20). However, the application of this material was limited due to its high sensitivity. It is well known that the shape, size, and structure of energetic materials (EMs) significantly influence their sensitivity.

[Determination of immunoglobulin G in mare colostrum by high-performance gel permeation chromatography].

A direct high-performance gel permeation chromatographic (HPGPC) method for the determination of immunoglobulin G in mare colostrum was established. HPGPC separation was performed on a TOSOH TSK-G4000PW(XL) column (300 mm x 7.8 mm, 5 microm) with 0.