The scar that takes time to heal: A systematic review of COVID-19-related stigma targets, antecedents, and outcomes.

COVID-19, as a crucial public health crisis, has affected our lives in nearly every aspect. Besides its major health threats, COVID-19 brings severe secondary impacts, one of which is the rise of social stigma. Although numerous studies have examined the antecedents and outcomes of COVID-19-related stigma, we still lack a systematic understanding of who is being stigmatized during the COVID-19 pandemic, what exacerbates COVID-19-related stigma, and what impacts COVID-19-related stigma has on victims.

A Hybrid of FeS Nanoparticles Encapsulated by Two-Dimensional Carbon Sheets as Excellent Nanozymes for Colorimetric Glucose Detection.

Recently, the development of nanozymes with high catalytic performance is gaining more and more attention due to the ever-growing demands for their practical applications. The elaborate design of its morphology has demonstrated to be an effective approach to improve the performance of these nanozymes. Herein, a hybrid of iron disulfide nanoparticles (FeS NPs) encapsulated by two-dimensional (2D) carbon nanosheets (NSs), denoted as FeS@C NSs, demonstrates both superior peroxidase-like activity and excellent stability.

Two-dimensional FeP@C nanosheets as a robust oxidase mimic for fluorescence detection of cysteine and Cu.

In the past few years, the development of novel nanozymes with excellent performance has attracted increasing attention in biosensing. However, most of those nanozymes were found to possess peroxidase activity with the prerequisite of the presence of H2O2. In contrast, oxidase mimics can catalyze the oxidation of substrates without H2O2, delivering a higher signal-to-noise ratio than that of peroxidase mimics in practical applications.

High peroxidase-like activity realized by facile synthesis of FeS nanoparticles for sensitive colorimetric detection of HO and glutathione.

In the last decades, enzyme mimics have been regarded as strong substitutes to natural enzymes. The construction of biosensors based on these enzyme mimics with competitive catalytic activity and substrate specificity has attracted a lot of research interest. Herein, for the first time, we investigated the capability of nanoscale FeS to serve as enzyme mimics.

TiO nanowires as an effective sensing platform for rapid fluorescence detection of single-stranded DNA and double-stranded DNA.

Numerous nanomaterials have been utilized for novel biosensors with sensitivity and selectivity in the last decades due to their intrinsic unique properties. Herein, a facile fluorescence method for nucleic acid detection was developed by employing TiO nanowires (NWs) as the sensing platform. The quenching effect of TiO NWs to fluorophore-labelled single-stranded DNA (ssDNA) was found to be more significant than that to fluorophore-labelled double-stranded DNA (dsDNA) or triplex DNA probes.

A Sensitive Near-Infrared Fluorescent Probe for Detecting Heavy Metal Ag⁺ in Water Samples.

Silver is a common catalyst in industrial production, and the frequent use of Ag⁺ can cause water pollution. Thus, the detection of Ag⁺ in the environment is necessary to determine the level of pollution from silver. In this work, we designed a new, highly selective near-infrared (NIR) fluorescent probe QCy to detect Ag⁺.

An electrochemical enzymatic nanoreactor based on dendritic mesoporous silica nanoparticles for living cell HO detection.

The selective and quantitative detection of cellular H2O2 is essential for understanding its roles in physiology and pathology. A new electrochemical H2O2 biosensor, fabricated by immobilizing horseradish peroxidase onto dendritic mesoporous silica nanoparticles (HRP/DMSNs), is employed for living cell H2O2 detection. Taking advantage of the large pore volume and highly accessible internal surface areas of DMSNs, HRP/DMSNs display higher enzymatic loading, better stability and bioactivity in comparison with HRP on nonporous silica nanoparticles (NSNs).

Polydopamine functionalized nanoporous graphene foam as nanoreactor for efficient electrode-driven metabolism of steroid hormones.

Understanding the enzymatic reaction kinetics of cytochrome P450 (CYP) within confined spaces is essential for the development of efficient CYP bioreactors in vitro. Herein, a facile electrochemical enzymatic nanoreactor (CYP3A4/PNGFs) is constructed by immobilizing CYP3A4 inside polydopamine (PDA) modified nanoporous graphene foams (PNGFs) whose pore diameter is controllable by the template of silica spheres. Taking advantages of the unique 3-D structure of NGFs and the ideal crosslinking agent of PDA, CYP3A4 is easily absorbed into PNGFs with high stability and bioactivity.

A designable aminophenylboronic acid functionalized magnetic FeO/ZIF-8/APBA for specific recognition of glycoproteins and glycopeptides.

We fabricated a novel aminophenylboronic acid functionalized magnetic FeO/zeolitic imidazolate framework-8/APBA (denoted as FeO/ZIF-8/APBA). First, FeO was coated by zeolitic imidazolate framework-8 (denoted as FeO/ZIF-8) using the hydrothermal method. Next, the phenylboronic acid functionalized triethoxysilane reagent was synthesized by 3-aminophenylboronic acid and 3-isocyanatopropyltriethoxysilane, which was modified on the surface of the FeO/ZIF-8 nanocomposite through the sol-gel technique and electrostatic interaction as well as π-π stacking interaction.

Fluorescence detection of cholesterol using a nitrogen-doped graphene quantum dot/chromium picolinate complex-based sensor.

Nitrogen-doped graphene quantum dots (N-GQDs), with superior biocompatibility, strong resistance to photobleaching and convenient surface grafting, have sparked a surge of related-bio applications. In this study, combined with chromium picolinate (CrPic), N-GQDs synthesized by a facile hydrothermal approach are used to construct an environmentally-friendly sensor for the detection of cholesterol by exploiting the fluorescence enhancement of N-GQDs/CrPic. Herein, CrPic is grafted on N-GQDs via the linker of cysteamine (Cys), and the fluorescence of the N-GQDs is quenched by photoinduced electron transfer (PET), wherein CrPic functions as an electron donating group and the N-GQDs serves as an electron accepting group.

A click-activated fluorescent probe for selective detection of hydrazoic acid and its application in biological imaging.

Here we present a new approach to aqueous hydrazoic acid detection through the synthesis and evaluation of an alkyne-based fluorescent probe, which could be applied in the monitoring of hydrazoic acid in both living Hela cells and larval zebrafish. This probe can also serve as an early warning automaton which would alert when both azide and protons exist over the threshold value.