A chiral porous organic cage-modified restricted-access material achieves online analysis of serum samples containing enantiomers and positional isomers.

Restricted-access materials (RAMs) allow biological samples to directly enter the chromatographic column for analysis owing to the steric exclusion function ability for biomolecules and extraction function for small-molecule analytes, which promoting the development of rapid, efficient, and automated in vivo drug analysis. Few reports on chiral RAMs that have been used to analyze enantiomers and positional isomers in serum by direct injection in currently. In this study, a chiral porous organic cage material RCC3 was innovatively introduced into the inner surface of silica gel and modified the outer surface with polyethylene glycol to prepare a novel type of chiral RAM-RCC3, and reported the use of chiral RAM-RCC3 as a stationary phase for the separation of chiral compounds and positional isomers in blank serum using high-performance liquid chromatography.

Efficacy and Safety of Huachansu as an Adjuvant Therapy for Non-Small Cell Lung Cancer: An Overview of Systematic Reviews and Meta-Analyses.

Objective: The purpose of this overview is to assess systematic reviews (SRs)/ meta-analyses (MAs) of Huachansu (HCS) combination chemotherapy for treating non-small cell lung cancer (NSCLC) and provide summarized evidence for clinical decision making.

Methods: From the creation of the database to JUNE 2023, 8 databases in English and Chinese were searched. SRs/MAs that met the inclusion and exclusion criteria were included.

[Accumulative levels of organochlorine pesticides of HCHs, DDTs in breast milk and risk factors analysis in Shenzhen].

Objective: To first investigate the accumulative levels of DDTs and HCHs in human breast milk of primipara in Shenzhen area, analyze influencing factors and assess exposure risk of infant in Shenzhen.

Methods: From April in 2011 to April in 2012, 85 primiparas who have lived in Shenzhen over 3 years after parturition 4 - 6 weeks were recruited, and their breast milk were collected and questionnaires were filled out simultaneously. The samples were extracted five times with hexane, cleaned up by gel permeation chromatograph (GPC) and SPE, and quantified by gas chromatography-election capture detection (GC-ECD).

[A rapid gas chromatographic method for determination of P-tert-butyl toluene in the air of workplace].

Objective: To establish a rapid gas chromatographic method for determination of P-tert-Butyl toluene in the air of workplace.

Methods: The air samples were collected by syringes, injected directly to the GC system, and then separated by a FFAP capillary column (30m x 0.53mm x 0.