Publications by authors named "Yueting Liang"
Article Synopsis
- Gastric cancer patients with peritoneal metastasis show poor survival due to therapeutic resistance and worsening conditions, especially with malignant ascites; however, the specifics of the peritoneal microenvironment during treatment are not well understood.
- * In a study involving 48 patients, researchers analyzed samples from primary tumors, peritoneal metastases, and malignant ascites using advanced techniques like single-cell RNA sequencing and spatial transcriptomics to uncover cellular interactions.
- * The findings revealed that certain cancer cells associated with poor prognosis were closely linked to fibroblasts and macrophages, which showed increased activity in malignant ascites; interactions among these cells could explain resistance to treatments, indicating potential targets for future therapies.*
Background: Hypertension and frailty often coexist in older people. The present study aimed to evaluate the association of frailty status with overall survival in elderly hypertensive patients, using data from the Chinese Longitudinal Healthy Longevity Survey.
Methods: A total of 10,493 elderly hypertensive patients were included in the present study (median age 87.
Background: Albeit considered with superior survival, around 30% of the early-stage non-squamous non-small cell lung cancer (Ns-NSCLC) patients relapse within 5 years, suggesting unique biology. However, the biological characteristics of early-stage Ns-NSCLC, especially in the Chinese population, are still unclear.
Methods: Multi-omics interrogation of early-stage Ns-NSCLC (stage I-III), paired blood samples and normal lung tissues (n=76) by whole-exome sequencing (WES), RNA sequencing, and T-cell receptor (TCR) sequencing were conducted.
Background: The clinical significance of tertiary lymphoid structure (TLS) in gastric cancer (GC) was uncertain.
Methods: A systematic search was performed in public databases for eligible studies as of April 2, 2023. Meta-analyses were performed to interrogate the associations between TLS levels and prognosis and immunotherapy response of GC.
The intricate mechanism of PLS3 in bone homeostasis and disease.
Front Endocrinol (Lausanne)
July 2023
Article Synopsis
- Scientists found out in 2013 that problems with a gene called PLS3 can make bones weak.
- PLS3 is important for how bone cells work, and it affects things like how cells communicate, manage calcium, and grow.
- This review tries to explain how PLS3 affects different bone cells and why understanding it better might help create better treatments for bone diseases.
Article Synopsis
- VLCFA synthesis in plants is mainly regulated by the enzyme 3-ketoacyl CoA synthase (KCS), which impacts the rate and length of fatty acid chains, crucial for pollen wall development.
- The study identified 24 grapevine genes and categorized them into seven subgroups based on their chromosome location and similar structures, indicating gene family expansion due to segmental duplications.
- Analysis comparing gene expression in a male sterile grape ('Y-14') and its fertile parent ('Shine Muscat') revealed 10 key genes impacted during meiosis that are involved in fatty acid elongation, potentially affecting pollen wall integrity and providing insights for grapevine breeding improvements.
Disruption of susceptibility (S) genes in crops is an attractive breeding strategy for conferring disease resistance. However, S genes are implicated in many essential biological functions and deletion of these genes typically results in undesired pleiotropic effects. Loss-of-function mutations in one such S gene, Mildew resistance locus O (MLO), confers durable and broad-spectrum resistance to powdery mildew in various plant species.
View Article and Find Full Text PDFEfficient and modular genome editing technologies that manipulate the genome of bacterial pathogens will facilitate the study of pathogenesis mechanisms. However, such methods are yet to be established for Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of rice bacterial blight.
View Article and Find Full Text PDFWhile there is no cure for chronic obstructive pulmonary disease (COPD), its progressive nature and the formidable challenge to manage its symptoms warrant a more extensive study of the pathogenesis and related mechanisms. A new emphasis on COPD study is the change of energy metabolism. For the first time, this study investigated the anaerobic and aerobic energy metabolic pathways in COPD using the metabolomic approach.
View Article and Find Full Text PDFOur study intended to longitudinally explore the prediction effect of immunoglobulin A (IgA) on pulmonary exudation progression in COVID-19 patients. The serum IgA was tested with chemiluminescence method. Autoregressive moving average model was used to extrapolate the IgA levels before hospital admission.
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