Publications by authors named "Yuesheng Dong"
Intratumoral and fecal microbiota reveals microbial markers associated with gastric carcinogenesis.
Front Cell Infect Microbiol
October 2024
Background: The relationship between dysbiosis of the gastrointestinal microbiota and gastric cancer (GC) has been extensively studied. However, microbiota alterations in GC patients vary widely across studies, and reproducible diagnostic biomarkers for early GC are still lacking in multiple populations. Thus, this study aimed to characterize the gastrointestinal microbial communities involved in gastric carcinogenesis through a meta-analysis of multiple published and open datasets.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers developed multifunctional sandwich-structured nanofiber dressings (SNDs) with specific layers designed for improved healing and antibacterial effects, incorporating materials like polylactic acid and metformin.
- * SNDs demonstrated effective antibacterial properties, photothermal capabilities, and the ability to reduce harmful reactive oxygen species, along with promoting tissue healing and reducing inflammation, making them a promising solution for diabetic wound care.
Osteoporosis, a prevalent chronic health issue among the elderly, is a global bone metabolic disease. Flavonoids, natural active compounds widely present in vegetables, fruits, beans, and cereals, have been reported for their anti-osteoporotic properties. Onion is a commonly consumed vegetable rich in flavonoids with diverse pharmacological activities.
View Article and Find Full Text PDFArticle Synopsis
- * Flavonoids enhance metformin's protective effects at a 0.5% concentration, with specific structural features (like ortho substitution and gallate configuration) crucial for their synergistic action.
- * The flavonoid EGCG boosts ROS scavenging and prevents cell death through specific pathways, allowing a lower metformin dose to be effective when combined, suggesting a new approach to target neuroprotection against ROS-induced damage and amyloid plaque formation.
Article Synopsis
- Bacteriophages, or phages, are gaining popularity as a solution for antibiotic-resistant infections, but traditional methods to prepare them are costly and prone to contamination.
- Researchers used Klebsiella pneumoniae, typically a pathogen, to convert glycerol into 1,3-propanediol (1,3-PDO) and then reused the bacteria to produce phages from fermentation broth.
- The study implemented a two-step extraction process that effectively removed impurities while yielding both 1,3-PDO and phages, presenting a cost-effective and eco-friendly approach for their simultaneous production.
Dynamic immobilization of bacterial cells on biofilm in a polyester nonwoven chemostat.
Bioresour Bioprocess
January 2024
Article Synopsis
- Cell immobilization is crucial for using viable cells as biocatalysts in biocatalysis to create high-value products.
- A new polyester nonwoven chemostat was developed to study how cells form biofilms and the balance of cells attaching and detaching from the polyester surface.
- The polyester nonwoven effectively supports cell immobilization, demonstrating a dynamic process where cells adhere through extracellular polymeric substances, which helps maintain overall biological activity.
Article Synopsis
- Protein tyrosine phosphatases (PTPs) are important targets for drugs aimed at treating conditions like cancer and diabetes, and the study focused on discovering new drug candidates by using marine fungi (DL1045) treated with a histone deacetylase inhibitor (SAHA).
- The research found that 46% of the secondary metabolites produced were regulated, with 20 newly biosynthesized metabolites identified specifically in the chemical epigenetic regulation (CER) broth, including a novel compound.
- Some of the metabolites, particularly sydowimide A (A11) and diorcinol (A3), exhibited potent inhibitory effects on specific PTPs, with diorcinol showing the strongest activity against SH
The stomach was once considered a sterile organ until the discovery of . With the application of high-throughput sequencing technology and macrogenomics, researchers have identified fungi and fivemajor bacterial phyla within the stomachs of healthy individuals. These microbial communities exert regulatory influence over various physiological functions, including energy metabolism and immune responses.
View Article and Find Full Text PDFArticle Synopsis
- Prediabetes is linked to chronic inflammation, obesity, and insulin resistance, and natural compounds like DNJ and morin from Morus nigra L. show promise for anti-diabetic effects, though DNJ has some side effects.
- This study aimed to explore how the combination of DNJ and morin can improve insulin resistance and prediabetes using mouse models and cell assays.
- Results showed that the combination significantly reduced the progression of type 2 diabetes by modulating key signaling pathways, enhancing insulin sensitivity, and reducing lipid accumulation.
Article Synopsis
- - The Q-426 strain, isolated from compost, shows promising antifungal properties against various plant pathogens, but its complete genome was not fully mapped, hindering its broader use.
- - Genome sequencing revealed that Q-426 has a circular chromosome that is 4,086,827 bp long with 4,691 coding sequences. It has been reclassified as B. velezensis Q-426 and is similar to other strains, indicating potential for plant growth-promoting activities.
- - The strain produces various beneficial compounds, including lipopeptides, volatile compounds, and indole-3-acetic acid (IAA), all of which may enhance plant growth and protection against diseases.
Article Synopsis
- Polysaccharide (DOP) acts as a prebiotic and shows potential hypoglycemic properties, particularly in preventing type 2 diabetes mellitus (T2DM).
- In a study with prediabetic mice, DOP treatment led to a 63.7% reduction in the risk of developing T2DM and improved gut health by altering the microbiota and reducing inflammation.
- DOP also increased beneficial gut bacteria that produce short-chain fatty acids, which played a role in hormone secretion that supports insulin sensitivity and reduces appetite.
Diseases caused by bacterial infection have resulted in serious harm to human health. It is crucial to develop a multifunctional antibiotic-independent antibacterial platform for combating drug-resistant bacteria. Herein, titanium diboride (TiB) nanosheets integrated with quaternized chitosan (QCS) and indocyanine green (ICG) were successfully prepared as a synergetic photothermal/photodynamic antibacterial nanoplatform (TiB-QCS-ICG).
View Article and Find Full Text PDFArticle Synopsis
- Traditional methods for breaking down cells in genetic engineering have high costs and low efficiency, presenting a major challenge for industrial applications.
- This study explored a new method combining phage lysis and salting-out extraction, finding that T7 phage can effectively break down host cells and release enzymes quickly.
- The combined process shows potential for being a more cost-effective and efficient alternative to traditional cell disruption techniques, thanks to its favorable operating conditions and effective separation.
Antarctic krill is a crucial marine resource containing plenty of high-valued nutrients. However, krill oil as a single product has been developed by the current solvent extraction with high cost. From the perspective of comprehensive utilization of Antarctic krill, this study proposed a novel two-step enzymolysis-assisted extraction in attempt to produce value-added oil and enzymolysate simultaneously.
View Article and Find Full Text PDFArticle Synopsis
- Chemical epigenetic regulation (CER) enhances the production of fungal secondary metabolites, but traditional study methods are labor-intensive and slow.
- In this study, researchers used a histone deacetylase inhibitor, suberohydroxamic acid (SBHA), along with advanced LC-MS/MS analysis and metabolomic tools to identify changes in metabolite profiles of the fungus DL1011.
- The results revealed the formation of 18 new secondary metabolites, with a notable percentage having never been discovered before, and showed that some of these compounds exhibited bioactive properties, indicating that CER effectively diversifies fungal metabolites.
Article Synopsis
- * A study tested 25 flavonoids to see how well they protected nerve cells from damage, revealing that certain structural features enhanced their protective effects.
- * The most effective flavonoid, EGCG, worked by reducing oxidative stress through specific cellular signaling pathways, suggesting that flavan-3-ols could be useful dietary supplements for preventing brain issues in diabetes.
[Quantitative proteomics reveals the abnormal liver metabolism-relieving effect of in type 2 diabetes mellitus rats].
Sheng Wu Gong Cheng Xue Bao
October 2022
Type 2 diabetes mellitus (T2DM) is a global metabolic disease with potentially life- threatening complications. Liver metabolism plays a vital role in the occurrence and development of diabetes mellitus. It has been reported that the Chinese medicinal (AR) can relieve insulin resistance and diabetes mellitus.
View Article and Find Full Text PDFArticle Synopsis
- * A study found that treatment with total flavonoids from L. reduced the progression of prediabetes to type 2 diabetes from 93.75% to 18.75%.
- * The research identified that TFM improves insulin resistance and maintains intestinal health by targeting specific proteins, suggesting possibilities for developing functional foods aimed at diabetes prevention.
The ComPA two-component signal transduction system (TCS) is essential in Bacillus spp. However, the molecular mechanism of the histidine kinase ComP remains unclear. Here, we predicted the structure of ComP from Bacillus amyloliquefaciens Q-426 (BaComP) using an artificial intelligence approach, analyzed the structural characteristics based on the molecular docking results and compared homologous proteins, and then investigated the biochemical properties of BaComP.
View Article and Find Full Text PDFArticle Synopsis
- Metabolic syndrome (MS) is highlighted as a serious metabolic disorder with various complications, which may benefit from natural treatments.
- The study focuses on mulberry leaf extract (MLE), rich in flavonoids, and its ability to regulate lipid metabolism and alleviate symptoms of MS in both lab experiments and live animal models.
- Results indicate that MLE significantly reduces lipid accumulation, improves obesity and insulin resistance, and positively alters gut microbiota and short-chain fatty acid levels, suggesting its potential as a dietary supplement for combating MS.
Article Synopsis
- Scientists are looking for new ways to use phages, which are viruses that can fight bacteria, especially since some bacteria are becoming resistant to antibiotics.
- A study found a faster and cheaper method to extract and purify a specific phage called phiAB9 using a special salt and solvent mix.
- This new method is more effective than older methods since it managed to recover over 90% of the phage while also getting rid of most unwanted proteins and bacteria.
Article Synopsis
- The combination of the flavonoid baicalein and the diabetes medication acarbose may lower the risk of prediabetes progressing to type 2 diabetes, though the specific mechanism of action is still unclear.
- In this study, researchers optimized in vitro conditions to replicate gut microbiota from prediabetic mice, achieving over 30% similarity with actual fecal samples.
- Results showed that combining baicalein with acarbose reduced gas production by lowering starch levels and affected gut bacteria, suggesting potential for developing flavonoid supplements alongside diabetes medications for better effectiveness and fewer side effects.*
Article Synopsis
- * A mixed solution of 10% PBS and 90% methanol was used to facilitate the reaction and effectively separate the products, achieving over 97% yield and 94% recovery for the FACylated product.
- * After purification, the resulting product (C-LOX) demonstrated promising pharmacokinetic and pharmacodynamic properties, suggesting potential industrial application for its production.
Microbial co-culture simulates the natural ecosystem through the combination of artificial microbes. This approach has been widely applied in the study of activating silent genes to reveal novel secondary metabolites. However, there are still challenges in determining the biosynthetic pathways.
View Article and Find Full Text PDFCrystal structure of the domain-swapped dimeric maltodextrin-binding protein MalE from Salmonella enterica.
Acta Crystallogr D Struct Biol
May 2022
MalE is a maltose/maltodextrin-binding protein (MBP) that plays a critical role in most bacterial maltose/maltodextrin-transport systems. Previously reported wild-type MBPs are monomers comprising an N-terminal domain (NTD) and a C-terminal domain (CTD), and maltose-like molecules are recognized between the NTD and CTD and transported to the cell system. Because MBP does not undergo artificial dimerization, it is widely used as a tag for protein expression and purification.
View Article and Find Full Text PDF