Prognostic Impact of Adjuvant Immunotherapy in Patients With Resectable NSCLC After Neoadjuvant Chemoimmunotherapy: A Brief Report.

Objective: The potential survival benefits of adjuvant immunotherapy for resectable NSCLC after neoadjuvant chemoimmunotherapy, and the optimal number of adjuvant immunotherapy cycles, remain uncertain. This study aims to evaluate the prognostic impact of adjuvant immunotherapy and determine the optimal number of cycles.

Methods: A total of 438 patients who received neoadjuvant chemoimmunotherapy between August 2019 and June 2022 across four hospitals were enrolled in this study, with a median follow-up time of 31.

Transcriptionally Active Human Papillomavirus in Male Genital Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Penile Squamous Cell Carcinoma.

Penile intraepithelial neoplasia (PeIN) and penile squamous cell carcinoma (PeSCC) are both thought to be associated with male genital lichen sclerosus and human papillomavirus (HPV) infection through dichotomous pathways: (i) undifferentiated PeIN and warty/basaloid PeSCC are thought to be HPV related, whereas (ii) differentiated PeIN and usual PeSCC are considered HPV independent. Tissue arrays were constructed from male genital lichen sclerosus, undifferentiated and differentiated PeIN, usual-type PeSCC, and unaffected tissues. Staining for p16 and for high-risk and low-risk HPV subtypes through RNAscope was performed.

"Internet+" pharmacy in psychiatric hospital amid COVID-19 and post-pandemic period: analysis and development.

Objective: This study aims to explore the differences in "Internet+" pharmacy prescriptions in psychiatric hospitals before and after the outbreak of the coronavirus disease 2019 (COVID-19) pandemic. It also seeks to examine changes in patient healthcare behaviors in the post-pandemic era and to identify the potential role of "Internet+" pharmacy in improving the current healthcare system.

Methods: Prescriptions from the "Internet+" pharmacy at The Affiliated Mental Health Center of Jiangnan University, collected between December 1, 2021, and November 30, 2023, were analyzed.

Current status of FAP-directed cancer theranostics: a bibliometric analysis.

Fibroblast activation protein (FAP) is a key molecule in the field of oncology, with significant impacts on tumor diagnosis and treatment. Importantly, it has paved the way for the development of radiotracers for quinoline-based FAP inhibitors (FAPIs), which are currently among the most promising radiotracers for PET imaging in cancer. We performed a bibliometric analysis of scientific publications related to FAP and FAPI-based radiotracers, which included the quantification and visualization of current research trends and prospects based on various bibliometric indicators.

A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis.

Objectives: The study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD).

Methods: Various databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies published from the beginning to February 2024.This meta-analysis utilized RevMan 5.

Google Trends applications for COVID-19 pandemic: A bibliometric analysis.

Introduction: COVID-19 is one of the most severe global health events in recent years. Google Trends provides a comprehensive analysis of the search frequency for specific terms on Google, reflecting the public's areas of interest. As of now, there has been no bibliometric study on COVID-19 and Google Trends.

Impact of utilization of oxygen scavenger on aroma quality of Longjing tea during storage at elevated temperature.

The fresh aroma of Longjing tea is vulnerable to unfavorable storage conditions. However, limited research has addressed effective solutions apart from low-temperature storage. This study aimed to investigate the impact of oxygen scavenger on aroma quality of packaged Longjing tea samples at elevated storage temperatures.

The role of cisplatin in modulating the tumor immune microenvironment and its combination therapy strategies: a new approach to enhance anti-tumor efficacy.

Cisplatin is a platinum-based drug that is frequently used to treat multiple tumors. The anti-tumor effect of cisplatin is closely related to the tumor immune microenvironment (TIME), which includes several immune cell types, such as the tumor-associated macrophages (TAMs), cytotoxic T-lymphocytes (CTLs), dendritic cells (DCs), myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and natural killer (NK) cells. The interaction between these immune cells can promote tumor survival and chemoresistance, and decrease the efficacy of cisplatin monotherapy.

Global and Regional Burden of Type 2 Diabetes Mellitus Attributable to Low Physical Activity From 1990 to 2021.

Aim: Type 2 diabetes mellitus (T2DM) contributes to the heavy burden, but there lacks latest and comprehensive global research on the burden of T2DM attributable to low physical activity (LPA). This study aimed to quantify the global and regional burden of T2DM attributable to LPA from 1990 to 2021.

Methods: We utilized data including disability-adjusted life years (DALYs), mortality, age-standardized disability-adjusted life years (ASDR), and age-standardized mortality rates (ASMR) from the Global Burden of Disease (GBD) 2021.

Avian pathogenic alters complement gene expression in chicken erythrocytes.

1. Avian () causes significant losses in livestock by inducing morbidity and mortality. Erythrocytes, the most abundant in blood, possess dual functions of oxygen transportation and immune regulation.

The Virulence Gene and Drug Resistance Analysis of Shiga Toxin-Producing from Diarrhea Calves in Xinjiang, China.

This investigation aimed to examine the virulence genes and antimicrobial resistance profiles of Shiga toxin-producing (STEC) strains found in diarrheal calves in Xinjiang between 2016 and 2022. A total of 800 samples, including 232 fecal and 568 rectal swabs from calves under 2 months old with diarrhea, were analyzed for Shiga toxin (Stx)-encoding genes using polymerase chain reaction. The study characterized the isolates based on their subtypes, virulence genes, O serogroups, phylogenetic groups, hemolytic phenotypes, antibiotic resistance, and resistance genes.

FOXM1-Cx31 Axis Drives Pancreatic Cancer Stem Cell-Like Properties and Chemoresistance.

Pancreatic cancer is a highly lethal malignancy with few effective treatment options. Connexin 31 (Cx31) is a membrane protein capable of forming hexameric channels to facilitate the exchange of metabolites and signaling molecules. Yet, the contribution of Cx31 to the onset and progression of pancreatic cancer remains to be understood.

Simultaneous Isolation and Preparation of Extracellular Vesicles by Circular Multicavity Electrophoresis.

Extracellular vesicles (EVs) play a crucial role in diagnosis and treatment, yet obtaining highly purified EVs from complex biological samples is often hindered by nanoscale contaminants. In this work, considering the charge-to-size characteristics of EVs, a circular multicavity electrophoresis (CME) with gradient pore size distribution was constructed in the gradient electric field to realize the isolation and preparation of EVs. By the gradient gel sieving effect, small cell debris, EVs, and proteins in biological samples were gradually separated.

Measured Resection as Gap Balance Method in Mobile-Bearing Medial Unicompartmental Knee Arthroplasty: A Randomized Controlled Trial.

Objective: Gap balancing is a vital process during mobile-bearing unicompartmental knee arthroplasty (MB-UKA). However, this process commonly depends on the surgeon's experience and lacks specific unified standards. This study aimed to propose and evaluate a novel "measured resection" method for gap balance in MB-UKA.

Enhancement of Osseointegration via Endogenous Electric Field by Regulating the Charge Microenvironments around Implants.

The regulation of the charged microenvironment around implants is an effective way to promote osseointegration. Although homeostasis of the charged microenvironment plays an integral role in tissues, current research is externally invasive and unsuitable for clinical applications. In this study, functional materials with different surface potential differences are prepared by changing the spatial layout of Ta and Ag on the surface of a Ti-6Al-4V alloy (TC4).

Enhancing the Performance of Hole-Conductor-Free Printable Mesoscopic Perovskite Solar Cells through Polyaniline-Mediated Iodine Recycling and Defect Passivation.

Printable mesoscopic perovskite solar cells (p-MPSCs) provide an opportunity for low-cost manufacturing of photovoltaics. However, the performance of p-MPSCs is severely compromised by iodine defects. This study presents a strategy by incorporating polyaniline (PANI) to achieve both iodine recycling and iodine defect passivation to significantly improve the performance of p-MPSCs.

N,O Co-Doped Carbon Spheres Enable Stable Anode-Less Sodium Metal Batteries.

Anode-less sodium metal batteries (SMBs) suffer from the formation of Na dendrites and inactive Na on an anode substrate though showing advantages of high energy densities and low costs. Herein, N,O co-doped carbon spheres (NOCS), which are synthesized via a scalable polymerization and pyrolysis method, are employed as a thin and stable sodiophillic nucleation layer on the Cu foil. Combined with electrochemical measurements, Na deposition morphology observations and density functional theory calculations, it is revealed that the introduced N and O heteroatoms can greatly enhance the adsorption of Na on the carbon substrate and reduce the nucleation overpotential, thus forming sufficient seeding sites and guiding homogeneous Na deposition.

Lung protective ventilation guided by driving pressure improves pulmonary outcomes in heart transplantation.

This study aimed to investigate whether driving pressure-guided ventilation can reduce postoperative pulmonary complications in patients who have undergone heart transplantation. Patients who underwent orthotopic heart transplantation were divided into two groups according to the perioperative ventilation strategy: (1) conventional lung-protective ventilation (group C) and (2) driving pressure-guided ventilation (group D). The primary outcome was the occurrence of postoperative pulmonary complications within 30 days of surgery.

Application value of central venous-arterial carbon dioxide partial pressure difference in postoperative cognitive dysfunction in patients with acute aortic dissection.

Objective: This study aims to investigate the clinical application value of the central venous-arterial carbon dioxide partial pressure difference (Pv-aCO2) in postoperative cognitive dysfunction(POCD) in patients with acute aortic dissection.

Methods: A retrospective analysis was conducted on the general data of 236 patients. Blood gas samples were collected from the arterial and venous lines at various time points during the surgery, including before and after the initiation of cardiopulmonary bypass (CPB), immediately after CPB initiation, before and after deep hypothermic circulatory arrest, 30 min after rewarming, and 5 min before weaning from CPB.

A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas.

Bacterial pneumonia is a significant public health burden, contributing to substantial morbidity, mortality, and healthcare costs. Current therapeutic strategies beyond antibiotics and adjuvant therapies are limited, highlighting the need for a deeper understanding of the disease pathogenesis. Here, we employed single-cell RNA sequencing of 444,146 bronchoalveolar lavage fluid cells (BALFs) from a large cohort of 74 individuals, including 58 patients with mild (n = 22) and severe (n = 36) diseases as well as 16 healthy donors.

[Clinical update in critical care of pulmonary medicine 2024].

This review outlines significant clinical research developments in the field of critical care respiratory medicine from October 2023 to September 2024. In the post-pandemic era, the new global definition of acute respiratory distress syndrome (ARDS) has improved practicality and early warning capabilities, although further refinement through respiratory mechanics and multi-omics approaches is required. Novel patterns of pulmonary microbiota distribution in ARDS patients have emerged, with microbiota-host immune interactions significantly influencing clinical outcomes.