Trans-Arterial Embolization for Liver Metastases of Gastroenteropancreatic Neuroendocrine Tumors: Response Indicates Survival Benefit?

Objective: To determine the impact of trans-arterial embolization (TAE) on overall survival (OS) in patients with liver metastases from gastroenteropancreatic neuroendocrine tumors (LM-GEP-NETs) and to identify factors that may influence tumor response to TAE treatment.

Methods: This study included patients with histologically and radiologically confirmed LM-GEP-NETs who received TAE treatment at The First Affiliated Hospital, Sun Yat-sen University, between November 2016 and January 2023. Imaging responses were assessed using Response Evaluation Criteria in Solid Tumors (RECIST) 1.

Associations of Retinal Microvascular Density and Fractal Dimension with Glaucoma: A Prospective Study from UK Biobank.

Objective: To explore the association between retinal microvascular parameters and glaucoma.

Design: Prospective study.

Subjects: The UK Biobank subjects with fundus images and without a history of glaucoma.

Retinal vascular fingerprints predict incident stroke: findings from the UK Biobank cohort study.

Objective: To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk.

Methods: Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk factors, to examine the associations, with false discovery rate adjustment for multiple comparisons.

Locking compression plate as a sequential external fixator following the distraction phase for the treatment of tibial bone defects caused by fracture-related infection: experiences from 22 cases.

Background: The purpose of this study was to report the clinical and psychological outcomes of using a locking compression plate (LCP) as a sequential external fixator following the distraction phase in the treatment of tibial bone defects caused by fracture-related infection (FRI).

Methods: We retrospectively analyzed the clinical records and consecutive X-ray images of patients with tibial bone defects who were treated with an LCP as a sequential external fixator following the distraction phase, between June 2017 and December 2022. The ASAMI criteria were applied to assess the bone and functional outcomes, and postoperative complications were evaluated by using the Paley classification.

Optimization of Ultrasound Extraction of Total Anthocyanin From Rupr. by Response Surface Methodology and Its Antihypertensive Effect.

Rupr. is a berry fruit shrub found in the north-western region of China, locally its fruit is consumed as a tea ingredient a part of the daily diet, for treatment of different diseases like eczema, and for cardiovascular care as a traditional remedy. In the current study, an optimized ultrasound-assisted extraction (UAE) method is developed using response surface methodology (RSM) to extract anthocyanins from the fruit.

Optimizing bone transport strategies: a pixel value ratio-based evaluation of regeneration rates in bifocal and trifocal techniques.

Background: Bone transport techniques are crucial for managing large bone defects, but the optimal approach for different defect lengths remains unclear. This study aimed to compare bone regeneration rates between short bifocal bone transport (SBBT), long bifocal bone transport (LBBT), and trifocal bone transport (TBT) using pixel value ratio (PVR) as an objective quantitative measure.

Methods: This retrospective study included 60 patients undergoing lower limb bone transport, divided into SBBT ( = 22, defects <6 cm), LBBT ( = 20, defects ≥6 cm), and TBT ( = 18, defects ≥6 cm) groups.

[Efficacy of early goal-directed renal replacement therapy in severe pneumonia associated acute kidney injury].

To evaluate the efficacy of early goal-directed renal replacement therapy (GDRRT) in patients with severe pneumonia associated acute kidney injury (AKI). Patients with severe pneumonia and diagnosed with AKI, and underwent GDRRT at Zhongshan Hospital between January 1, 2017 and December 31, 2022 were retrospectively enrolled. All patients were divided into early RRT group and regular RRT group according to fluid status, inflammation progression, and hemodynamics at RRT initiation.

Integrating 3D-printed customized guides with hemicorticotomy bone transport: clinical outcomes in chronic osteomyelitis management.

Purpose: Chronic osteomyelitis with large bone defects remains a challenging condition in orthopedic surgery. This study aimed to evaluate the clinical efficacy of hemicorticotomy bone transport assisted by 3D-printed customized guides in the treatment of chronic osteomyelitis with bone defects.

Methods: A retrospective analysis was conducted on 21 patients with chronic osteomyelitis treated with hemicorticotomy bone transport with 3D-printed guide assistance between January 2015 and January 2021.

Objective assessment of docking site consolidation in bone transport: the role of pixel value ratio in predicting healing outcomes.

Background: The management of docking site healing in bone transport remains a significant challenge in orthopedic surgery. Traditional assessment methods rely heavily on qualitative radiographic evaluations. This study investigates the utility of pixel value ratio (PVR), an objective quantitative measure, in assessing bone healing at the docking site during bone transport.

Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach.

Background: Muscle atrophy caused by denervation is common in neuromuscular diseases, leading to loss of muscle mass and function. However, a comprehensive understanding of the overall molecular network changes during muscle denervation atrophy is still deficient, hindering the development of effective treatments.

Method: In this study, a sciatic nerve transection model was employed in male C57BL/6 J mice to induce muscle denervation atrophy.

Empyema Caused by and Complicated by Secondary Pulmonary Infection from : A Case Report.

is a gram-positive anaerobic coccus that can cause infections in immunocompromised individuals. causing empyema has not been reported earlier. Here, we present a novel case of empyema caused by .

Bactrian Camel Milk: Chemical Composition, Bioactivities, Processing Techniques, and Economic Potential in China.

Bactrian camel (BC) milk has gained increasing attention due to its unique nutritional profile and potential bioactivities. This comprehensive review explores the chemical composition, bioactivities, processing techniques, and economic potential of BC milk in China. The distinctive chemical composition of BC milk, including protein, lipid, carbohydrate, vitamin, and mineral content, is discussed, emphasizing its differences from other mammalian milk.

CO-Based micro-respirometry for measuring bacterial load under aerobic and anaerobic conditions.

The bacterial load (BL), or total viable count, of aerobes can be measured using micro-respirometry, %O-μR, in which the consumption of dissolved O is monitored with respect to incubation time, . In %O-μR the 'bioreactor' often comprises a canonical plastic tube with a small %O sensor; it is simple, fast and accurate and used in automated, commercial instruments for measuring BL. Here we show that it is also possible to measure BL using a new form of micro-respirometry, %CO-μR, in which the production of CO in the growth medium is monitored.

Multifunctional Bioactivity Electrospinning Nanofibers Encapsulating Emodin Provide a Potential Postoperative Management Strategy for Skin Cancer.

Skin cancer is threatening more and more people's health; its postoperative recurrence and wound infection are still critical challenges. Therefore, specialty wound dressings with multifunctional bioactivity are urgently desired. Emodin is a natural anthraquinone compound that has anti-cancer and anti-bacterial properties.

Early wound infection monitoring via headspace O micro-respirometry.

A luminescence based, inexpensive, 3D printed O indicator is incorporated into a commercial, clear, occlusive wound dressing, which allows the %O in the headspace above a simulated wound to be monitored. Two wound models are used to evaluate this micro-respirometry-based system for monitoring wound infection namely, a simple 'agar plug' model and a wounded porcine skin model. Inoculation of either wound model with E.

Early goal-directed renal replacement therapy in severe pneumonia associated acute kidney injury.

Introduction: Severe pneumonia is a crucial issue in the development of acute kidney injury (AKI). This study evaluated the efficacy of early goal-directed renal replacement therapy (GDRRT) for the treatment of severe pneumonia-associated AKI.

Methods: In this real-world retrospective cohort study, we recruited 180 patients with severe pneumonia who were hospitalized and received GDRRT in a third-class general hospital in East China between January 1, 2017, and December 31, 2021.

[Effect of accordion technique and deferoxamine on promoting bone regeneration in distraction osteogenesis].

Objective: To compare the effects of hypoxia-inducible drugs using deferoxamine (DFO) and accordion technique (AT) on activating the hypoxia-inducible factor 1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway to promote bone regeneration and remodelling during consolidation phase of distraction osteogenesis (DO).

Methods: Forty-five specific-pathogen-free adult male Sprague-Dawley (SD) rats were randomly divided into the control group, DFO group, and AT group, with 15 rats in each group. All rats underwent osteotomy to establish a right femur DO model.

Management strategies for Docking Site refractures: a comparative analysis of 19 patient cases.

Aims: This study aimed to compare the clinical effectiveness of intramedullary nailing (IMN), percutaneous external plate fixation (PEPF), and re-applied external fixation (REF) in the treatment of refracture at the consolidated docking site following the removal of external fixation in patients with tibial defects who had previously undergone the Ilizarov bone transport technique.

Methods: A retrospective review was performed on patients who received IMN, PEPF, or REF for refracture at the consolidated docking site subsequent to the removal of external fixation. A collection of data was made regarding the following parameters: age, gender, defect size, treatment methods, external fixation time (EFT), external fixation index (EFI), time of refracture (TOR) subsequent to fixation removal, and docking reunion time (DRT).

Advances in artificial intelligence for meibomian gland evaluation: A comprehensive review.

Meibomian gland dysfunction (MGD) is increasingly recognized as a critical contributor to evaporative dry eye, significantly impacting visual quality. With a global prevalence estimated at 35.8 %, it presents substantial challenges for clinicians.