A short review on environmental distribution and toxicity of the environmentally persistent free radicals.

Environmentally Persistent Free Radicals (EPFRs) are usually generated by the electron transfer of a certain radical precursor on the surface of a carrier. They are characterized with high activity, wide migration range, and relatively long half-life period. In this review, we summarized the literature on EPFRs published since 2010, including their environmental occurrence and potential cytotoxicity and biotoxicity.

Construction, expression, purification, characterization, and structural analysis of microbial transglutaminase variants.

Microbial transglutaminase (MTG, EC 2.3.2.

Notch1 signaling is involved in regulating Foxp3 expression in T-ALL.

Background: T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. Immune tolerance induced by CD4+CD25+ regulatory T cells (Tregs) with high expression of Foxp3 is an important hypothesis for poor therapy response. Notch1 signaling is thought to be involved in the pathogenesis of this disease.

Evaluation of optical clearing with the combined liquid paraffin and glycerol mixture.

By scanning biological tissues in vivo and in vitro with optical coherence tomography, it is found that liquid paraffin can enhance the percutaneous penetration of glycerol in deep layers of tissue and take synergistically optical clearing effect with glycerol. It is shown from experimental results that 30% - 50% liquid paraffin glycerol solutions have the best enhancement effect. Considering the refractive index of liquid paraffin and its medicinal value, we think liquid paraffin will play an important role in optical clearing as the penetration enhancer of glycerol in future clinical research.