Nonreciprocal optomechanically induced transparency and enhanced ground-state cooling in a reversed-dissipation cavity system.

We explore the prospects of phase-modulated optical nonreciprocity and enhanced ground-state cooling of a mechanical resonator for the reversed-dissipation system, where the dissipative coupling between two cavities is realized through the adiabatic elimination of a low-Q mechanical mode, while a high-Q mechanical mode interacts with two mutually coupled cavities, forming a closed-loop structure. This unique system facilitates the nontrivial phenomenon of optomechanically induced transparency (OMIT), which exhibits asymmetry due to the frequency shift effect. We also observe the emergence of parity-dependent unidirectional OMIT windows (appearing under the phase-matching condition), which can be dynamically modulated by both the phase factors and the strength of the dissipative coupling.

Construction and validation of a risk assessment model for acute kidney injury in patients with acute pancreatitis in the intensive care unit.

Background: To construct and validate a risk assessment model for acute kidney injury (AKI) in patients with acute pancreatitis (AP) in the intensive care unit (ICU).

Methods: A total of 963 patients diagnosed with acute pancreatitis (AP) from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database was included. These patients were randomly divided into training set (N = 674) and validation set (N = 289) at a ratio of 7:3.

Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis.

The underlying mechanism by which growth factor receptor-bound protein 2 (Grb2) regulates necroptosis remains unexplored. In the present study, we found that rasfonin, a fungal natural product and an activator of necroptosis, enhanced Grb2 binding to receptor-interacting serine/threonine kinase 1 (RIP1), which plays a critical role in regulating programmed necrosis. Moreover, we observed that SQSTM/p62 (p62), a protein that can form necrosomes with RIP1, increased its interaction with Grb2 upon rasfonin challenge.

Diterpenoids and C Nor-Isoprenoid Identified From the Leaves and Twigs of Activating Apoptosis and Pyroptosis.

(Family Euphorbiaceae) is an annual aromatic plant endemic to Yunnan Province, China, which yields an aromatic, spicy oil used as a flavoring and fragrance. The aim of the present study was to acquire secondary metabolites from the leaves and twigs of and to evaluate their cytotoxic activity. Five new diterpenoids, croyanhuins A-E (-), and one new C nor-isoprenoid, croyanhuin F (), were isolated from the leaves and twigs of .

New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus sp.

Two new diterpenoids, hypoxyterpoids A () and B (), and four new isocoumarin derivatives, hypoxymarins A-D (-), together, with seven known metabolites ( and -) were obtained from the crude extract of the mangrove-derived fungus sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds , , , and were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4' in and C-9 in were determined by [Rh(OCOCF)]-induced ECD spectra.

Polyoxygenated sesquiterpenoids from Salvia castanea and their potential anti-Alzheime's disease bioactivities.

Salvia castanea (Family Labiatae), a perennial fragrant herb with castaneous flowers, is mainly distributed in areas with an altitude of 2500-3750 m. The roots of this plant were used as a tea drink by local residents to strengthen physical health. The aim of present study was to acquire secondary metabolites of the ethanol extract obtained from the whole plant of S.

A new highly oxygenated germacranolide from var. (C.B.Clarke) Kitam.

A new highly oxygenated germacranolide, carcerlane A (), together with four known highly oxygenated germacranolides (-), was isolated from an ethanol extract of the whole plant of var. (C.B.

Cadinane-type sesquiterpenes from the resinous exudates of Commiphora myrrha and their anti-Alzheimer's disease bioactivities.

Commiphoins A-C (1-3), three new cadinane-type sesquiterpenes, together with two known cadinane-type sesquiterpenes (4 and 5) were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were established on the basis of comprehensive spectroscopic methods, including HRESIMS, 1D and 2D NMR analyses. Compounds 1 and 3-5 were screened for anti-Alzheimer's disease (AD) activities using the AD pathological model in Caenorhabditis elegans.