Unveiling the role of taurine and SLC6A6 in tumor immune evasion: Implications for gastric cancer therapy.

Metabolic changes are key drivers of tumor progression. Understanding how metabolic reprogramming promotes tumor development and identifying key metabolic activities are essential for improving tumor diagnosis and treatment. Among the numerous transporters in the body, solute carriers (SLCs) are particularly significant, often overexpressed in cancer cells to meet the tumor's demand for nutrients and energy.

Computed Tomography Signs of Sinonasal Inflammation in Patients with Acute Dacryocystitis.

Background: Nasal and paranasal sinus abnormalities may be related to nasolacrimal duct obstructive disease but are strongly debated. Data of acute disease stage are lacking.

Objective: The purpose of this study was to determine if there are correlations between radiologic signs of sinus inflammation and acute dacryocystitis (AD).

Exploring clinical indicator variations in stroke patients with multiple risk factors: focus on hypertension and inflammatory reactions.

Background: Stroke stands as the second leading cause of death worldwide. Currently, extensive research has been conducted on stroke risk factors. However, when stroke patients contend with multiple risk factors, the impact on clinical indicators remains uncertain.

Densely Connected Networks with Multiple Features for Classifying Sound Signals with Reverberation.

In indoor environments, reverberation can distort the signalseceived by active noise cancelation devices, posing a challenge to sound classification. Therefore, we combined three speech spectral features based on different frequency scales into a densely connected network (DenseNet) to accomplish sound classification with reverberation effects. We adopted the DenseNet structure to make the model lightweight A dataset was created based on experimental and simulation methods, andhe classification goal was to distinguish between music signals, song signals, and speech signals.

Chromatic visual evoked potentials identify optic nerve dysfunction in patients with Graves' orbitopathy.

Purpose: To explore visual dysfunction in Graves' orbitopathy (GO) objectively by analyzing chromatic visual evoked potentials (cVEP) and evaluate its diagnostic efficiency for dysthyroid optic neuropathy (DON).

Methods: In this cross-sectional study, we analyzed pattern-reversal VEP (pVEP), red-green (R-G) and blue-yellow (B-Y) cVEP in 93 subjects (21 with DON, Group A, 30 with GO, Group B, and 42 healthy controls, Group C) at Wuhan Union Hospital, China.

Results: Compared with Group C, the amplitudes of B-Y cVEP were significantly lower in Group B, whereas all amplitudes of cVEP, latencies and amplitudes of pVEP in Group A were significantly impaired.

In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves' orbitopathy.

Background: To evaluate microstructural changes in the meibomian glands (MGs) in patients with active and inactive Graves' orbitopathy (GO), using in vivo confocal microscopy (IVCM), and to investigate the correlations between clinical and confocal findings.

Methods: Forty patients (80 eyes) with GO (34 eyes with active GO, 46 eyes with inactive GO), and 31 age- and sex-matched control participants (62 eyes) were enrolled consecutively. A researcher recorded the clinical activity score (CAS) for each patient.

Retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after orbital decompression for dysthyroid optic neuropathy.

Purpose: To determine the prognostic value of optical coherence tomography (OCT) measurement of the peripapillary retinal nerve fiber layer (RNFL) thickness in visual recovery after orbital decompression of patients with dysthyroid optic neuropathy (DON).

Methods: A total of 52 eyes of 37 patients who underwent orbital decompression for DON between 2013 and 2019 were retrospectively reviewed. We examined peripapillary RNFL thickness, best-corrected visual acuity (BCVA), visual field (VF) for mean deviation (MD) and pattern standard deviation (PSD), and pattern-reversed visual evoked potential (PVEP) for P100 latency and amplitude before and after surgery.

Comparison of 2-wall versus 3-wall orbital decompression against dysthyroid optic neuropathy in visual function: A retrospective study in a Chinese population.

To compare visual function of 2-wall (medial and lateral) versus 3-wall (medial, lateral, and inferior) orbital decompression in patients with dysthyroid optic neuropathy (DON).A total of 52 eyes of 37 patients underwent orbital decompression for DON between 2013 and 2019 were retrospectively reviewed. Two- or 3-wall decompression was performed in 31 eyes of 23 patients and 21 eyes of 14 patients, respectively.

Nanomotor-based adsorbent for blood Lead(II) removal and in pig models.

Blood lead (Pb(II)) removal is very important but challenging. The main difficulty of blood Pb(II) removal currently lies in the fact that blood Pb(II) is mainly complexed with hemoglobin (Hb) inside the red blood cells (RBCs). Traditional blood Pb(II) removers are mostly passive particles that do not have the motion ability, thus the efficiency of the contact between the adsorbent and the Pb(II)-contaminated Hb is relatively low.

Near-infrared-driven fluorescent nanomotors for detection of circulating tumor cells in whole blood.

It is of great significance to develop micro/nanomotors with good biosafety and high efficiency for biomedical detection. In order to enhance the contact chances between the biosensors and the analytes in the complex blood sample, we report a near-infrared light (NIR)-driven fluorescent nanomotor, which can safely and efficiently capture and detect circulating tumor cells (CTCs) in the whole blood environment without pretreating procedures. Firstly, the structure of the fluorescent nanomotor was characterized and its motion behavior in different environments was analyzed.

Ocular Manifestations and Clinical Characteristics of Children With Laboratory-Confirmed COVID-19 in Wuhan, China.

Importance: Ocular manifestations and outcomes in children with confirmed coronavirus disease 2019 (COVID-19), relevant affecting factors, and differences in ocular disease between children and adults have yet to be fully understood.

Objective: To investigate ocular manifestations and clinical characteristics of children with laboratory-confirmed COVID-19.

Design, Setting, And Participants: This cross-sectional study was conducted at Wuhan Children's Hospital in Wuhan, China.

Platelet-derived porous nanomotor for thrombus therapy.

The treatment difficulties of venous thrombosis include short half-life, low utilization, and poor penetration of drugs at thrombus site. Here, we develop one kind of mesoporous/macroporous silica/platinum nanomotors with platelet membrane (PM) modification (MMNM/PM) for sequentially targeting delivery of thrombolytic and anticoagulant drugs for thrombus treatment. Regulated by the special proteins on PM, the nanomotors target the thrombus site and then PM can be ruptured under near-infrared (NIR) irradiation to achieve desirable sequential drug release, including rapid release of thrombolytic urokinase (3 hours) and slow release of anticoagulant heparin (>20 days).

Erythrocyte Membrane-Wrapped Magnetic Nanotherapeutic Agents for Reduction and Removal of Blood Cr(VI).

The hazard of hexavalent chromium (Cr(VI)) from environmental pollution and medical implanted metal has been recognized widely. However, removal of trace amount of Cr(VI) in the blood circumstance faces tremendous difficulties for that most of Cr(VI) located in erythrocytes, thus there is almost no literature to report the removal of Cr(VI) in blood. Herein, a removal strategy, named as reduction-adsorption-separation, is proposed to realize the removal of Cr(VI) in blood.

Systematic Research and Evaluation Models of Nanomotors for Cancer Combined Therapy.

Limited tumor permeability of therapeutic agents is a great challenge faced by current cancer therapy methods. Herein, a kind of near infrared light (NIR)-driven nanomotor with autonomous movement, targeted ability, hierarchical porous structure, multi-drugs for cancer chemo/photothermal therapy is designed, prepared and characterized. Further, we establish a method to study the interaction between nanomotors and cells, along with their tumor permeability mechanism, including 2D cellular models, 3D multicellular tumor spheroids and in vivo models.

Novel heparin-loaded mesoporous tubular micromotors formed via template-assisted electrochemical deposition.

Based on the concept of the active drug delivery of micro- and nanomotors and the longer cycle time in the blood for drug-loaded tubular particles, it is important to develop novel tubular micromotors that could increase drug loading and achieve more effective treatments in the biomedical field. Here, a novel kind of mesoporous tubular micromotor used to load heparin (Hep) and formed via template-assisted electrochemical deposition is presented. Firstly, the mesoporous tubular micromotors were composed of poly(3,4-ethylenedioxythiophene) (PEDOT), mesoporous silica (MS) and manganese dioxide (MnO), and were simply fabricated via template-assisted electrochemical growth.

Dynamic early warning of regional atmospheric environmental carrying capacity.

Economic development cannot exceed the maximum amount that the environment can support. Therefore, atmospheric environmental policy should be formulated based on the scientific assessment of regional atmospheric environmental carrying capacity. The establishment of an early warning model of atmospheric environmental carrying capacity can dynamically analyse regional atmospheric environmental carrying capacity, which contributes to discerning the change trend of the regional atmospheric environmental carrying capacity and the risk issue of the regional atmospheric environment.

Spatial agglomeration of new energy industries on the performance of regional pollution control through spatial econometric analysis.

With the increasing prominence of China's energy security and environmental pollution issues, improving environmental control performance is significant for China to achieve a sustainable economy and environment. In this study, the impact of the spatial agglomeration of the new energy industry on the regional pollution control performance was considered in a spatial econometric model. From the two perspectives of technology patents and employees, the impact of the spatial agglomeration of the new energy industry was explored using the spatial panel data model.

A dual-responsive biosensor for blood lead detection.

Simple and accurate detection of trace heavy metals in blood is very important. A novel dual-responsive electrochemical/fluorescent biosensor based on magnetic hyperbranched polyamide with heparin modification (MHPAM-H) for blood lead detection has been successfully developed. Upon conjugated with blood lead ions, dual-biosensor could not only display electrochemical signal but also fluorescence signal owing to the enriched amino groups, cavity structure, and good fluorescence properties of HPAM.

Author Correction: Bio-inspired nitric-oxide-driven nanomotor.

The original version of this Article contained an error in the first sentence of the second paragraph of the 'Influence of HLA nanomotors on the cells (HUVECs and MCF-7)' section of the Results, which incorrectly read 'In order to verify the universality of the formation mechanism of HLA nanomotors proposed in this case, that is, the positively charged amino-enriched organic substances and the negative carboxyl groups in L-arginine combined through weak electrostatic force to form nanoparticles, three amino-enriched organic compounds (chitosan, (Mw. 5-100 million), polylysine (Mw. 3000-4000), heparin/folic acid (FA) (Mw.

Bio-inspired nitric-oxide-driven nanomotor.

Current chemical-fuel-driven nanomotors are driven by gas (e.g. H, O, NH) which only provides motion ability, and can produce waste (e.

Development of novel affinity reagents for detecting protein tyrosine phosphorylation based on superbinder SH2 domain in tumor cells.

Tyrosine phosphorylation, as a hallmark in cellular signal transduction, is important for a diverse array of cellular processes, such as proliferation, metabolism, motility, and survival. Aberrant tyrosine phosphorylation plays a causal role in many diseases, especially the cancer. Detecting protein phosphorylation status in the cancer cells or tissues is vital for assessing the pathological phase, discovering the cancer biomarkers, and identifying the drug targets.