Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability.

DNA transactions introduce torsional constraints that pose an inherent risk to genome integrity. While topoisomerase 1 (TOP1) activity is essential for removing DNA supercoiling, aberrant stabilization of TOP1:DNA cleavage complexes (TOP1ccs) can result in cytotoxic DNA lesions. What protects genomic hot spots of topological stress from aberrant TOP1 activity remains unknown.

Hybrid Adaptive Cubature Kalman Filter with Unknown Variance of Measurement Noise.

This paper is concerned with the filtering problem caused by the inaccuracy variance of measurement noise in real nonlinear systems. A novel weighted fusion estimation method of multiple different variance estimators is presented to estimate the variance of the measurement noise. On this basis, a hybrid adaptive cubature Kalman filtering structure is proposed.