Recurrent pelvic organ prolapse in a patient with history of bladder exstrophy.

Background: Increased risk of pelvic organ prolapse in women with a history of bladder exstrophy poses difficult management owing to the absence of anterior support and pelvic angle. We present a case of recurrent prolapse in the setting of bladder exstrophy and discuss factors that may warrant consideration during the evaluation of such patients.

Case: A 26-year-old nulliparous woman with a history of bladder exstrophy and pelvic organ prolapse initially repaired with a porcine graft sacral hysteropexy presented with suspected recurrent apical prolapse.

Imprecision of urinary iothalamate clearance as a gold-standard measure of GFR decreases the diagnostic accuracy of kidney function estimating equations.

Background: Evaluating the accuracy of estimated glomerular filtration rate (eGFR) derived from serum creatinine (SCr) and serum cystatin C (SCysC) equations requires gold-standard measures of GFR. However, the influence of imprecise measured GFRs (mGFRs) on estimates of equation error is unknown.

Study Design: Diagnostic test study.