Publications by authors named "Yuenan Liu"

Article Synopsis
  • - The study investigated the link between exposure to certain phthalates (PAEs) and overall mortality in diabetic patients over a ten-year period, finding that 446 out of 2806 cases died during the study. - Significant associations between specific PAEs (like DMP, DiBP, DnBP, and DEHP) and increased mortality rates were noted, but only in male participants, with hazard ratios indicating a higher risk compared to the lowest exposure quartile. - Molecular analysis suggested that PAEs influence mortality through hormonal and IL-6-related pathways, with genetic variations in related hormones also affecting how these phthalates impact health outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • COVID-19 is linked to long-lasting fatigue, and understanding how thyroid hormone levels relate to this fatigue can help improve quality of life post-infection.
  • A study in Dalian, China, followed 40 COVID-19 patients to compare those experiencing fatigue with those who weren't, assessing thyroid hormone (FT) levels and fatigue using a specific scale after six months.
  • Results showed that lower FT levels were significantly associated with fatigue, identifying a critical FT value that can predict long-term fatigue with high sensitivity.
View Article and Find Full Text PDF

Emerging evidence has linked arsenic exposure and metabolic homeostasis, but the mechanism is incompletely understood, especially at relatively low concentrations. In this study, we used a mouse model to evaluate the health impacts and metabolic toxicity of arsenic exposure in drinking water at environmentally relevant levels (0.25 and 1.

View Article and Find Full Text PDF

Relation prediction is a critical task in knowledge graph completion and associated downstream tasks that rely on knowledge representation. Previous studies indicate that both structural features and semantic information are meaningful for predicting missing relations in knowledge graphs. This has led to the development of two types of methods: structure-based methods and semantics-based methods.

View Article and Find Full Text PDF

Gut microbiome can influence the arsenic metabolism in mammals. Confusingly, gut microbiome was found to both mitigate and exacerbate arsenic toxicity. In this study, the role of gut microbiota in arsenic bioaccumulation, biotransformation, and organ toxicity in C57BL/6J mice was investigated.

View Article and Find Full Text PDF

Growing evidences supported that arsenic exposure contributes to non-alcoholic fatty liver disease (NAFLD) risk, but findings were still inconsistent. Additionally, once absorbed, arsenic is methylated into monomethyl and dimethyl arsenicals. However, no studies investigated the association of arsenic metabolism with NAFLD.

View Article and Find Full Text PDF

Background: Anoikis is a distinctive type of apoptosis. It is involved in tumor progression and metastasis. But its function in castration-resistant prostate cancer (CRPC) remains veiled.

View Article and Find Full Text PDF

As the most prominent RNA modification, N6-methyladenosine (m A) participates in the regulation of tumour initiation and progression. Circular RNAs (circRNAs) also play crucial roles in ubiquitous life processes. Whether circRNAs are required for m A regulation in renal cell carcinoma (RCC) remains unclear.

View Article and Find Full Text PDF

Growing studies investigated the association of arsenic metabolism with type 2 diabetes (T2D), however, the epidemiological evidence is inconsistent. In addition, the interaction of arsenic metabolism-related genetic risk score (GRS)-arsenic on T2D risk was unclear. The present study aimed to evaluate the association of arsenic metabolism efficiency [inorganic arsenic (iAs)%, monomethylarsonic acid (MMA)%, and dimethylarsinic acid (DMA%)] with T2D risk.

View Article and Find Full Text PDF

Prospective epidemiological evidence was lacking on the association of phthalates (PAEs) exposure with incident type 2 diabetes mellitus (T2DM) risk. In present nested case-control study, we identified 1006 T2DM cases and matched 1006 controls based on Dongfeng-Tongji cohort study, and 6 PAEs were detected in baseline serum. The conditional logistic regression model, Bayesian kernel machine regression (BKMR) model and Quantile-based g-computation were applied to evaluate the associations of determined PAEs, either as individuals or as a mixture, with incident T2DM risk.

View Article and Find Full Text PDF

Unlabelled: Fatty acid metabolism reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Increased lipid storage supports ccRCC progression, highlighting the importance of understanding the molecular mechanisms driving altered fatty acid synthesis in tumors. Here, we identified that malonyl-CoA decarboxylase (MLYCD), a key regulator of fatty acid anabolism, was downregulated in ccRCC, and low expression correlated with poor prognosis in patients.

View Article and Find Full Text PDF

Introduction: Adenoid hypertrophy is the main cause of obstructive sleep apnea in children. Previous studies have suggested that pathogenic infections and local immune system disorders in the adenoids are associated with adenoid hypertrophy. The abnormalities in the number and function of various lymphocyte subsets in the adenoids may play a role in this association.

View Article and Find Full Text PDF

Introduction: Obstructive sleep apnea (OSA) has been associated with psychiatric disorders, especially depression and posttraumatic stress disorder (PTSD). genetic variants have been previously reported to confer the risk of depression and PTSD. This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) in the gene with OSA and OSA-related quantitative traits.

View Article and Find Full Text PDF

Background: Obstructive sleep apnea (OSA) is highly prevalent yet underdiagnosed. This study aimed to develop a predictive signature, as well as investigate competing endogenous RNAs (ceRNAs) and their potential functions in OSA.

Methods: The GSE135917, GSE38792, and GSE75097 datasets were collected from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database.

View Article and Find Full Text PDF

Renal cell carcinoma (RCC) is characterized by the difficulties in early diagnosis and the propensity to metastases. For advanced RCC, sunitinib targeted therapy is the clinically recommended first-line drug and the major challenge of sunitinib treatment is adaptive resistance. Therefore, it is imperative to research the mechanisms underlying sunitinib resistance.

View Article and Find Full Text PDF

Renal cell carcinoma (RCC) is a serious threat to people's health due to its rapid progression, and patients easily develop resistance to targeted therapy. The absent in melanoma 2 (AIM2) is a receptor protein that has recently been proposed to play an important role in various diseases. In this study, AIM2 was identified as a new biomarker of RCC and promoted RCC progression and sunitinib resistance in an inflammasome-independent manner.

View Article and Find Full Text PDF
Article Synopsis
  • Previous studies on obstructive sleep apnea (OSA) fell short in defining cases and understanding genetic roles, leaving OSA's heritability largely unexplained.
  • A genome-wide association study involving 20,590 Han Chinese individuals discovered two significant genetic variants linked to OSA: the intronic variant rs6455893 and the missense variant rs3746804 in a riboflavin transporter.
  • The research identified multiple genetic loci related to OSA and sleep traits, suggesting potential therapeutic targets and emphasizing the importance of riboflavin in related physiological functions.
View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the role of long noncoding RNA COL18A1-AS1 in the lipid metabolism of clear cell renal cell carcinoma (ccRCC), finding that its downregulation is linked to poorer patient prognosis.
  • - COL18A1-AS1 is silenced due to DNA methylation, and restoring its expression can inhibit tumor progression while promoting lipid consumption, a process called lipid "browning."
  • - The research identifies a mechanism where COL18A1-AS1 interacts with miR-1286 to enhance KLF12 expression, which then activates UCP1 for lipid browning, offering insights for potential therapeutic approaches for ccRCC.
View Article and Find Full Text PDF

Obstructive sleep apnea (OSA) is the most common type of sleep apnea that impacts the development or progression of many other disorders. Abnormal expression of N6-methyladenosine (m6A) RNA modification regulators have been found relating to a variety of human diseases. However, it is not yet known if m6A regulators are involved in the occurrence and development of OSA.

View Article and Find Full Text PDF

Renal cell carcinoma (RCC) is one of the most common malignancies in the urinary system. The mortality of advanced RCC remains high despite advances in systemic therapy of RCC. Considering the misdiagnosis of early-stage RCC, the identification of effective biomarkers is of great importance.

View Article and Find Full Text PDF

Background: Despite rapid advances in the treatment of prostate cancer (PCa), the optimal treatment for elderly patients with PCa remains unclear due to a lack of high-quality evidence. This study aimed to evaluate whether surgical procedures are beneficial for PCa patients aged 75 years and older and compare the effects of focal ablation and prostatectomy.

Methods: Male patients aged 75 years and older who were diagnosed with Tis-T2/N0/M0 PCa between 2000 and 2017 were retrospectively identified from the Surveillance, Epidemiology, and End Results program database.

View Article and Find Full Text PDF

Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The CENP family is overexpressed in many types of cancers, but its functions in ccRCC have not been fully clarified.

View Article and Find Full Text PDF

This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion.

View Article and Find Full Text PDF
Article Synopsis
  • Ferroptosis is a new type of cell death linked to various diseases, particularly tumors, and is shown to influence the development of clear cell renal cell carcinoma (ccRCC), although its exact molecular mechanisms are not fully understood.
  • In a study, researchers developed a four-gene signature (FeSig) associated with ferroptosis, which showed promise for predicting diagnosis and survival outcomes in ccRCC.
  • The research uncovered a potential regulatory pathway (TAZ/WNT10B axis) that connects ferroptosis to tumor immunity, suggesting its value as a new biomarker and a target for immunotherapy in ccRCC.
View Article and Find Full Text PDF

Clear cell renal cell carcinoma (ccRCC) accounts for approximately 4/5 of all kidney cancers. Accumulation of minor changes in the cellular homeostasis may be one cause of ccRCC. Therefore, we downloaded the RNA sequencing and survival data of the kidney renal cell carcinoma (KIRC) cohort from the Cancer Genome Atlas (TCGA) database.

View Article and Find Full Text PDF