Publications by authors named "Yuenan Chen"

Purpose: To evaluate and compare the diagnostic value of contrast-enhanced transcranial Doppler (c-TCD) and contrast-enhanced transthoracic echocardiography (c-TTE) for right to left shunt (RLS) in patent foramen ovale (PFO) by meta-analysis.

Methods: The literature included in the Cochrane Library, PubMed, and Embase were searched by using "contrast-enhanced transcranial Doppler (c-TCD), contrast-enhanced transthoracic echocardiography (c-TTE), patent foramen ovale (PFO), and right to left shunt (RLS)" as the keywords from inception through April 30, 2024. The diagnostic accuracy research quality assessment tool (QUADAS-2) was used to evaluate the quality of the included literature.

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The study aims to explore the current status of hypertension control and its predictors in patients with hypertension in China and provide evidence for preventing and controlling hypertension. A questionnaire survey was conducted among 300 hypertensive patients who visited the Second Affiliated Hospital of Anhui Medical University from February 20, 2023 to March 11, 2023. The patients were divided into a well-controlled group and an untargeted-control group according to their hypertension control status.

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Purpose: To evaluate and compare the value of conventional ultrasound-based superb microvascular imaging (SMI) and color Doppler flow imaging (CDFI) in the diagnosis of malignant thyroid nodule by meta-analysis.

Methods: The literature included in the Cochrane Library, PubMed, and Embase were searched by using " superb microvascular imaging (SMI), color Doppler flow imaging (CDFI), ultrasound, thyroid nodules" as the keywords from inception through February 1, 2023. According to the inclusion and exclusion criteria, the clinical studies using SMI and CDFI to diagnose thyroid nodules were selected, and histopathology of thyroid nodules was used as reference standard.

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Purpose: To evaluate the diagnostic value of conventional ultrasound and elastosonography in malignant thyroid nodules by meta-analysis.

Methods: The literature included in the Cochrane Library, PubMed, and Embase were searched by using "elastosonography, ultrasonography, thyroid nodules" as the keywords. The clinical studies using elastosonography and conventional ultrasound to diagnose thyroid nodules were selected, and histopathology of thyroid nodules was used as reference standards.

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Background: Emerging evidence suggests that per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors and may contribute to the etiology of diabetes.

Objectives: This study aimed to systematically review the epidemiological evidence on the associations of PFAS with mortality and morbidity of diabetes and to quantitatively evaluate the summary effect estimates of the existing literature.

Methods: We searched three electronic databases for epidemiological studies concerning PFAS and diabetes published before April 1, 2022.

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Article Synopsis
  • - The study reviews existing research on how per- and polyfluoroalkyl substances (PFAS) impact birth outcomes, finding inconsistent evidence on this issue.
  • - After analyzing 46 eligible studies, the research revealed statistically significant associations between PFAS exposure and various adverse birth outcomes, such as lower birth weight and increased risk of preterm birth.
  • - The overall evidence suggests a "moderate" level of reliability, indicating PFAS exposure is linked to various negative effects on birth outcomes like gestational age and small for gestational age.
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Traffic noise has attracted much attention as a significant and intractable public health threat. This study was designed as a systematical review to explore the association of traffic noise with different indicators of obesity, thus providing updated quantitative estimates for the pooled effect estimates of the existing literature. We conducted an extensive search for epidemiological studies that investigated the association of traffic noise with obesity in three electronic databases till February 23, 2021.

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Depression is one of the most common mental illnesses in modern society. In recent years, several studies show that there are disturbances in lipid metabolism in depressed patients. High-fat diet may lead to anxiety and depression, but the mechanisms involved remain unclear.

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Alzheimer's disease (AD) is a neurodegenerative disorder, which has become the leading cause of dementia cases globally. Synaptic failure is an early pathological feature of AD. However, the cause of synaptic failure in AD, especially the GABAergic synaptic activity remains unclear.

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Article Synopsis
  • Researchers created poly(ε-caprolactone) (PCL) nano-aggregates ranging from 50 to 330 nm using a nanoprecipitation method, resulting in various shapes like spheres and ellipsoids.
  • They used techniques like SEM, TEM, and AFM to analyze the size and shape of these nano-aggregates, finding that the smallest (∼50 nm) were amorphous and did not display melting behavior in initial heating scans.
  • The study revealed that as the size of the PCL aggregates increased beyond 150 nm, they transitioned to a semi-crystalline state, indicating that larger aggregates are more likely to crystallize, with crystallinity improving alongside size.
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Surfactant-free nanospheres and latex nanospheres of poly(methyl methacrylate) (PMMA) with diameter ranging from 20 to 220 nm are prepared by atom transfer radical polymerization (ATRP) in microemulsions and subsequent dialysis against deionized water. The glass transitions of these PMMA nanospheres are characterized using nano differential scanning calorimetry (nano-DSC) in aqueous dispersions. The glass transition temperature (Tg) of the surfactant-free PMMA nanospheres and nonionic PMMA latex nanospheres with diameters below 150 nm is less than that of the PMMA bulk, and Tg decreases with the decrease of the diameter.

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