Publications by authors named "Yuen-Kiu Cheung"
Article Synopsis
- This study develops a universal pharmacokinetic (PK) model for MMAE-based antibody-drug conjugates (ADCs) to effectively analyze the PK of various ADCs utilized in clinical settings.
- A thorough literature review gathered data from clinical trials, resulting in the collection of 109 PK profiles from 18 different MMAE-based ADCs, which were dose-normalized to confirm the model's applicability across multiple ADC types.
- The study's findings enable predictions of PK exposure metrics based on dose levels, offering a crucial resource for understanding how these drugs behave in the body and establishing links between drug exposure and treatment outcomes.
Predictors, Mediators and Moderators of Police Work-Related Stress: A Scoping Review.
Int J Environ Res Public Health
January 2023
Owing to the complication in organisation, the dangerous job nature and the rise of demonstrations and protests across the world in the past decade, police work-related stress has become a topic of global concern. This review aimed to provide an understanding of predictors, mediators and moderators of police work-related stress from a multi-level perspective. Using a scoping review approach underpinned by the six-stage methodological framework, studies were found from six electronic databases (MEDLINE, Web of Science, Sociological Abstracts, Scopus, PsycINFO and PsychiatryOnline) and grey literature sources.
View Article and Find Full Text PDFAlthough work stress, turnover intention, and work-family conflicts among police officers have been extensively investigated, no studies have explored these issues simultaneously under the context of the coronavirus pandemic. Clearly, both work and family domains have been drastically affected by this global health crisis, and it is likely that each domain has a distinctive impact on work outcomes. Using survey data based on a representative random sample of 335 police officers in Hong Kong, this study examines the impacts of resource losses and gains across family and work domains on occupational stress and turnover intention amid the pandemic.
View Article and Find Full Text PDFArticle Synopsis
- Monomethyl auristatin E (MMAE) is a key component in antibody-drug conjugates (ADCs) but lacks comprehensive studies on its whole-body pharmacokinetics (PK).
- MMAE is rapidly cleared from the plasma but shows extensive and prolonged distribution in various tissues, with high concentration ratios in well-perfused organs and a significant tumor exposure compared to plasma.
- A physiological-based pharmacokinetic (PBPK) model was developed to accurately describe MMAE's PK across plasma, tissues, and tumors, aiding in the optimization of dose and transition from preclinical to clinical settings for MMAE-containing ADCs.
Previous studies have found inconsistent results regarding the personality predictors of scholastic cheating. This study investigated whether personality was a predictor of scholastic cheating using the HEXACO-60 personality inventory and the Dark Triad (DT). A sample of 252 students completed the online questionnaire.
View Article and Find Full Text PDF