Publications by authors named "Yuen Seng Tiong"
Rationale: Allergic sensitization is associated with poor clinical outcomes in asthma, chronic obstructive pulmonary disease, and cystic fibrosis; however, its presence, frequency, and clinical significance in non-cystic fibrosis bronchiectasis remain unclear.
Objectives: To determine the frequency and geographic variability that exists in a sensitization pattern to common and specific allergens, including house dust mite and fungi, and to correlate such patterns to airway immune-inflammatory status and clinical outcomes in bronchiectasis.
Methods: Patients with bronchiectasis were recruited in Asia (Singapore and Malaysia) and the United Kingdom (Scotland) (n = 238), forming the Cohort of Asian and Matched European Bronchiectasis, which matched recruited patients on age, sex, and bronchiectasis severity.
Article Synopsis
- Sensitization to multiple types of mites is linked to a higher risk of persistent asthma and other allergic diseases in children living in tropical Singapore.
- In a study of 253 children, most showed sensitization to common mite allergens, with varied responses indicating different types of allergic conditions.
- A more complex allergic phenotype (having both asthma and other allergic conditions) was associated with sensitization to a wider range of mites and a family history of asthma.