Publications by authors named "Yueming Chu"
Melanoma poses a significant challenge to patients due to its aggressive nature and limited treatment options. Recent studies have suggested that lasalocid, a feed additive ionophore antibiotic, may have potential as an anticancer agent. However, the mechanism of lasalocid in melanoma is unclear.
View Article and Find Full Text PDFCancer is a globally complex disease with a plethora of genetic, physiological, metabolic, and environmental variations. With the increasing resistance to current anticancer drugs, efforts have been made to develop effective cancer treatments. Currently, natural products are considered promising cancer therapeutic agents due to their potent anticancer activity and low intrinsic toxicity.
View Article and Find Full Text PDFDysfunction of the Hippo pathway is common in esophageal squamous carcinoma (ESCC). Chaetocin, a small molecular compound isolated from the marine fungus, exhibits potent anticancer effects. However, the anticancer effects of chaetocin on ESCC and its potential relationship to Hippo pathway remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- Oncogenes, like the Holliday Junction Recognition Protein (HJURP), play a significant role in cancer development, acting as a chaperone for histone H3 and influencing nucleosome composition.
- HJURP is found on chromosome 2q37.1 and is crucial for assembling centromere structures, with its dysfunction linked to tumorigenesis and poor cancer prognosis.
- Research indicates that HJURP is often overexpressed in various cancers, promoting cell proliferation and invasiveness, making it a potential target for innovative cancer therapies.