Publications by authors named "Yuemei Cheng"
Network pharmacology and metabolomics elucidate the underlying effects and mechanisms of maackiain against endometrial cancer.
Biochem Biophys Res Commun
January 2025
Endometrial carcinoma (EC), a prevalent gynecological cancer, is characterized by rising incidence and mortality rates, highlighting the need for novel treatments to improve patient outcomes. Maackiain (MA) is a natural compound isolated from common herbal medicines, that has been reported to have anti-cancer effects. However, the underlying roles and mechanisms concerning EC remain unclear.
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- Endometrial cancer (EC) is a common gynecological cancer linked to chronic inflammation, and ATP5F1D plays a role in mitochondrial function, which is crucial in cancer development.
- The study identified ATP5F1D expression in EC tissues and cell lines, revealing its connection to better clinical outcomes and negative impacts on cancer cell behavior when ATP5F1D is silenced.
- Knocking down ATP5F1D reduced mitochondrial ROS production and pyroptosis in EC cells, suggesting that targeting ATP5F1D could be a potential new treatment approach to slow down EC progression.
Article Synopsis
- Endometrial cancer (EC) is the most common gynecological cancer in developed countries, and the study focuses on the role of the gene ATP5F1D, a part of the mitochondrial electron transport chain.
- Researchers analyzed tissue samples from 20 EC patients using data-independent acquisition mass spectrometry (DIA-MS) and found that ATP5F1D showed a significant 2.903-fold change in expression, indicating its potential as a diagnostic and prognostic biomarker.
- The study revealed that higher ATP5F1D expression correlates with better immune treatment responses and chemotherapy sensitivity, highlighting its importance in guiding personalized treatment strategies for EC patients.
Data-independent acquisition for proteomic applications in early-stage endometrial cancer progression.
J Obstet Gynaecol Res
February 2024
Article Synopsis
- The study investigates the molecular changes in high-grade early-stage endometrial cancer (EC) patients, who often have poor outcomes despite an early diagnosis, focusing on proteome analysis to identify dysregulated pathways.
- Using data-independent acquisition (DIA) proteomics, the researchers analyzed tissue samples from 20 EC patients and identified significant differences in protein expression, particularly the upregulation of oxidative phosphorylation (OXPHOS) pathways in high-grade tumors.
- The findings suggest that high-grade EC is linked to metabolic reprogramming, with OXPHOS-related proteins being potential biomarkers for diagnosis and possible targets for new treatment strategies.
Background: GRP78 is a molecular chaperone protein in the endoplasmic reticulum that is involved in protein assembly and quality control, and it participates in ER stress regulation of endoplasmic reticulum stress pathways. Studies have confirmed that GRP78 gene is highly expressed in a variety of tumors and is involved in different biological functions.
Purpose: The present review highlights the involvement of the GRP78 gene in regulating the development of cervical cancer by promoting the proliferation and invasion of cervical cancer cells as well as by inhibiting apoptosis and promoting the Warburg effect.
Article Synopsis
- This study focused on how malignant peritoneal cytology relates to survival outcomes in patients with uterine leiomyosarcoma and endometrial stromal sarcoma.
- Out of 733 patients analyzed, those with malignant cytology had significantly lower 5-year overall survival rates, especially in advanced cases, indicating a serious prognosis.
- The findings suggest that assessing peritoneal cytology during hysterectomy could be beneficial for predicting patient outcomes and improving prognosis evaluation.
Article Synopsis
- Nicotinamide adenine dinucleotide (NAD+) is important for tumor progression, but its specific role in endometrial cancer (EC) is not fully understood, prompting this study.
- Researchers developed a risk signature based on NAD+ metabolic-related genes (NMRGs) to predict prognosis and responses to treatments in EC patients, using data from established cancer databases.
- The study identified six key NMRGs related to patient risk levels, demonstrating that a high-risk group faced poorer outcomes and showed a connection to specific biological pathways and immune responses, highlighting the signature's potential for guiding EC patient management.
SIK2: A critical glucolipid metabolic reprogramming regulator and potential target in ovarian cancer.
J Obstet Gynaecol Res
August 2023
Article Synopsis
- The study investigates how salt-inducible kinase 2 (SIK2) influences glucose and lipid metabolism in ovarian cancer, aiming to inform potential inhibitors for personalized treatment.
- By reviewing SIK2's roles in processes like glycolysis and lipid synthesis, the research highlights its contribution to cancer cell growth, invasion, and resistance to therapies.
- The findings suggest that targeting SIK2 could offer new treatment options for ovarian cancer and other cancers, leading to further exploration of its molecular mechanisms and the development of more effective inhibitors.
Article Synopsis
- The study aimed to determine the effectiveness of adjuvant radiotherapy on overall survival (OS) in patients with uterine sarcoma, particularly identifying those who would benefit from it using a nomogram-based prognostic stratification.
- Researchers analyzed data from 2871 uterine sarcoma patients without distant metastases and found that, while adjuvant radiotherapy didn't improve OS overall, high-risk patients experienced significant survival benefits.
- The developed nomogram effectively categorized patients into three risk groups, showing that only high-risk patients gained improved 5-year OS with radiotherapy, suggesting a targeted approach in treatment.
Polyetherimide- and folic acid-modified Fe O nanospheres for enhanced magnetic hyperthermia performance.
J Biomed Mater Res B Appl Biomater
April 2023
Recent studies have highlighted the development prospects of magnetic hyperthermia in cancer therapy. A few studies on the application of Fe O nanospheres for the magnetic hyperthermia of gynecological malignancies have achieved certain efficacy, but there was no visible progress currently. In this work, Fe O nanospheres modified with polyetherimide (PEI) and folic acid (FA) were synthesized using a hydrothermal method for possible utility in biocompatible and active tumor-targeting magnetic induction hyperthermia.
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- - Ovarian cancer (OC) is a highly aggressive cancer in women, characterized by a poor prognosis and the highest mortality rates among female cancers.
- - Circular RNAs (circRNAs) are emerging as important non-coding RNAs in cancer research, demonstrating roles in tumor development and showing specific expression patterns that vary by tissue and developmental stage.
- - This text summarizes the expression of circRNAs in ovarian cancer tissues and cell lines, highlighting their involvement in key biological processes such as cell growth, immune response, and resistance to chemotherapy through interactions with microRNAs and proteins.
Cell proliferation and migration play important parts in ovarian cancer progression. BMP9, as one of the members of the TGF-β superfamily and BMP family, plays a diverse and significant array of biological roles, including cell differentiation, proliferation, apoptosis, tumorigenesis, and metabolism. However, the role and mechanism of BMP9 in ovarian cancer progression remains uncertain.
View Article and Find Full Text PDFInfluence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2.
Probiotics Antimicrob Proteins
March 2018
Multidrug-resistant bacteria are emerging as a global threat, making the search for alternative compounds urgent. Antimicrobial peptides (AMPs) became a promising hotspot due to their distinct action mechanism and possibility to be used as an alternative or complement to traditional antibiotics. However, gaining a better understanding about the relationship between antimicrobial peptides structure and its bioactivity is crucial for the development of next generation of antimicrobial agents.
View Article and Find Full Text PDFIntroduction: Neuroligins are postsynaptic cell adhesion molecules that interact with neurexins to regulate the fine balance between excitation and inhibition of synapses. Recently, accumulating evidence, involving mutation analysis, cellular assays, and mouse models, has suggested that neuroligin (NLGN) mutations affect synapse maturation and function. Previously, four missense variations [p.
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