Approaches to Parapharyngeal Space and Infratemporal Fossa Based on Different Anatomical Spaces.

Objectives: The parapharyngeal space (PPS) and infratemporal fossa (ITF) present significant challenges for endoscopic skull base surgery due to their complex anatomy and lack of clear bony landmarks. This study aims to propose a systematic compartmentalization of the PPS and ITF, based on key anatomical structures, to optimize surgical planning and approaches.

Methods: To retain a precise bony reference framework, the walls of the maxillary sinus and pterygoid bone were preserved.

[Clinical analysis of endonasal endoscopic surgery in esthesioneuroblastoma].

To investigate the clinical characteristics of esthesioneuroblastoma and the efficacy of endonasal endoscopic surgery combined with radiotherapy/chemotherapy. The clinical and surgical data of 17 patients with esthesioneuroblastoma who underwent endonasal endoscopic surgery in our department from September 2009 to June 2023 were retrospectively analyzed. Among all patients, the modified Kadish stage B was identified in 4 patients, C in 10 patients, and D in 3 patients.

Increased SERPINB2 potentiates 15LO1 expression via STAT6 signalling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps.

Background: SERPINB2, a biomarker of Type-2 (T2) inflammatory processes, has been described in the context of asthma. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also correlated with T2 inflammation and elevated 15LO1 induced by IL-4/13 in nasal epithelial cells. The aim of this study was to evaluate the expression and location of SERPINB2 in nasal epithelial cells (NECs) and determine whether SERPINB2 regulates 15LO1 and downstream T2 markers in NECs via STAT6 signalling.

Insights from bioinformatics analysis reveal that lipopolysaccharide induces activation of chemokine-related signaling pathways in human nasal epithelial cells.

Lipopolysaccharide (LPS) is known to elicit a robust immune response. This study aimed to investigate the impact of LPS on the transcriptome of human nasal epithelial cells (HNEpC). HNEpC were cultured and stimulated with LPS (1 μg/mL) or an equivalent amount of normal culture medium.

PM activates IL-17 signaling pathway in human nasal mucosa-derived fibroblasts.

Fine particulate matter (PM) represents a prevalent environmental pollutant in the atmosphere, capable of exerting deleterious effects on human health. Numerous studies have indicated a correlation between PM exposure and the development of chronic upper airway inflammatory diseases. The objective of this study was to investigate the impact of PM on the transcriptome of fibroblasts derived from nasal mucosa.

Endoscopic endonasal combined transoral medial approach to the nasopharynx, parapharyngeal space, and jugular foramen.

Objective: This study aimed to validate the feasibility of an endoscopic endonasal combined transoral medial approach for treating lesions in the nasopharynx, parapharyngeal space (PPS), and jugular foramen.

Methods: Anatomical and imaging information of six patients who underwent surgery via this approach were reviewed and analyzed.

Results: The feasibility and advantages of the endoscopic endonasal combined transoral medial approach, which uses an inside-to-outside medial surgical corridor, were identified.

Abnormal luminescent property of Mn(2+) in α-LiZnBO3:Mn(2+).

Mn(2+)-activated red phosphor α-LiZnBO3:Mn(2+) was synthesized by solid state reaction. ESR spectra prove that the doped ions are Mn(2+). The doped Mn(2+) ion is inclined to occupy Zn(2+) site, which is a tetrahedral coordination.