Activation of Glycolysis by MCM10 Increases Stemness and Paclitaxel Resistance in Gastric Cancer Cells.

Background/aims: Chemotherapy is an essential avenue for curing malignancies; however, tumor cells acquire resistance to chemotherapeutic agents, eventually leading to chemotherapy failure. At present, paclitaxel (PTX) resistance seriously hinders the therapeutic efficacy of gastric cancer (GC). Investigating the molecular mechanism of PTX resistance in GC is critical.

Identification of Biomarkers Associated with the Prognoses of Colorectal Cancer Patients.

Introduction: Colorectal cancer (CRC) is a common cancer. As metastasis and recurrence are main causes of CRC death, it is of great significance to find prognostic biomarkers.

Methods: Data related to CRC were collected from GEO database.

Primary ascending colon cancer accompanying skip metastases in left shoulder skin and left neck lymph node: A case report.

Background: Lymph node skip metastases are common in lung, breast, and thyroid cancer patients, but are rare in colon cancer patients. Specifically, lymph node skip metastases occur in 1%-3% of colon cancer patients. Previous reports have demonstrated colon cancer skip metastases involving the retropancreatic and portocaval lymph nodes and Virchow's node; however, reports involving skip metastases into the left neck lymph nodes and left shoulder skin are extremely rare, as are related reports of clinical treatment and prognosis.

MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.

Background: A rich history of studies have manifested the importance of miRNAs to cancer progression, while miR-194-3p has been seldom explored.

Objective: The purpose of this study is to unearth the way the KLK10/miR-194-3p axis modulates colorectal cancer (CRC).

Methods: Differentially expressed genes of CRC in TCGA database were analyzed.

Research for Expression and Prognostic Value of GABRD in Colon Cancer and Coexpressed Gene Network Construction Based on Data Mining.

Colon cancer is one of the top five cancers with the highest incidence rate in the world. In order to better understand the pathogenesis and progression of colon cancer, it is still necessary to investigate the abnormally expressed genes in cancer tissue. In this study, the Oncomine database was used for expression analysis, and it was found that the expression level of gamma-aminobutyric acid type A receptor subunit delta (GABRD) gene was upregulated in colon cancer tissue compared with that in normal tissue.

TRIM32 Promotes the Growth of Gastric Cancer Cells through Enhancing AKT Activity and Glucose Transportation.

Tripartite motif protein 32 (TRIM32), an E3 ubiquitin ligase, is a member of the TRIM protein family. However, the underlying function of TRIM32 in gastric cancer (GC) remains unclear. Here, we aimed to explore the function of TRIM32 in GC cells.

Clinical outcomes of laparoscopic versus open right hepatectomy for liver tumors: A meta-analysis.

Background: Laparoscopic right hepatectomy (LRH) is one of the most challenging procedures. Right liver resections have been always performed in open procedure and open right hepatectomy (ORH) was initially considered as routine way. Moreover, it is unclear how beneficial the minimally invasive technique is to patients; thus, we conducted a meta-analysis to acquire a more reliable conclusion about the feasibility and safety of LRH compared with ORH.

[Application of three-dimensional laparoscopy in radical gastric cancer surgery].

Objective: To explore the application of three-dimensional (3D) high-definition (HD) laparoscopy in radical operation for stomach carcinoma.

Methods: A total of 12 cases of radical operation for stomach carcinoma were performed under 3D laparoscopy. The procedures included total gastrectomy (n = 6) and distal gastrectomy (n = 6).

Downregulated expression of metastasis associated in colon cancer 1 (MACC1) reduces gallbladder cancer cell proliferation and invasion.

Metastasis associated in colon cancer 1 (MACC1), a key regulator of the hepatocyte growth factor (HGF)/MET signaling pathway, has been implicated in multiple human cancers. However, little is known regarding its expression and biological function in human gallbladder cancer (GBC). In this study, we focused on the clinical significance and biological functions of MACC1 in GBC and found that MACC1 protein overexpression was frequently detected in GBC tissues.

[Significance of MACC1 protein expression in esophageal carcinoma].

Objective: To explore the expression of metastasis-associated colon cancer 1 (MACC1) proteins in esophageal carcinoma and neighboring tissues.

Methods: The expressions of MACC1 were detected in 60 specimens of esophageal carcinoma and neighboring tissues with immunohistochemistry and Western blotting. All the specimens were selected from 2010-2012 of Guangfu Hospital of Jinhua, 38 males and 22 females, aged (50 ± 12) years.