Correlation between dental fluorosis risk and bone-specific alkaline phosphatase, osteocalcin, matrix metalloproteinase and parathyroid hormone in children.

Background: The aim of this study was to investigate the association between dental fluorosis occurrence in children and bone metabolism-related indicators, including bone-specific alkaline phosphatase (BALP), osteocalcin (OC), matrix metalloproteinase (MMP-2, MMP-9, MMP-20), and parathyroid hormone (PTH).

Methods: A total of 189 cases of school-age children who underwent health examinations in our hospital were enrolled, according to the presence or absence of dental fluorosis. They were divided into the fluorosis group (n=97) and fluoride-free group (n=92), and the serum BALP, OC, MMP-2, MMP-9, MMP-20, and PTH levels of the two groups were compared and relevant clinical data were collected.

Clinical significance of activated Wnt/β-catenin signaling in apoptosis inhibition of oral cancer.

Wnt/β-catenin signaling is an evolutionarily conserved pathway and plays a crucial role in regulating cancer cell proliferation and tumorigenesis. However, the molecular mechanism behind the Wnt/β-catenin signaling-mediated carcinogenesis and apoptosis resistance in oral squamous cell carcinoma is not well characterized so far. In the present study, we have investigated the effect of β-catenin depletion of the perversely activated Wnt/β-catenin signaling pathway on apoptosis resistance and tumorigenesis of the human OSCC cell line SCC-55.

[The influence of zoledronic acid on proliferation, migration and apoptosis of fibroblasts].

Purpose: Bisphosphonates are commonly used to treat bone-derived malignant tumors currently. In recent years, with the widespread use of these drugs, reports on the difficulty of wound healing (DWH) increase remarkably. However, the mechanism is still unclear.

A Allele of Rs5498 and Rs3181092 is Correlated with Increased Risk for Periodontal Disease.

Objective: Periodontal disease (PD) is viewed today as multifactorial problems initiated and sustained by bacteria but significantly modified by the body's response to bacterial plaque. Recent studies have suggested that gene polymorphisms could be involved in the pathophysiology of periodontitis. This study aimed to investigate a possible correlation of the polymorphisms of intercellular adhesion molecule-1 () and vascular cell adhesion molecule-1 () with PD.

[Curative effects of partial caries removal in permanent molars with deep dental caries].

Purpose: To evaluate the clinical efficacy of incomplete caries removal in permanent molars with deep dental caries.

Methods: One hundred and two permanent molars with deep dental caries were treated with partial caries removal combined with tight resin restoration. The patients were followed up for more than 6 months, the pulp retention rate and subjective feelings were evaluated.

[Comparison of the results in 59 patients with mandibular fractures treated by internal rigid fixation and inter maxillary ligation].

Purpose: The purpose of this study is to explore the clinical effect of the miniplate osteosynthesis on the treatment of mandibular fractures.

Methods: 59 patients with mandibular fractures were randomly divided into two groups. In the first group,29 patients underwent arch bar splints fixation and intermaxillary ligation.