MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.

Acute coronary artery blockage leads to acute myocardial infarction (AMI). Cardiomyocytes are terminally differentiated cells that rarely divide. Treatments preventing cardiomyocyte loss during AMI have a high therapeutic benefit.

Wireless-Channel Key Distribution Based on Laser Synchronization.

We propose and experimentally demonstrate a wireless-channel key distribution scheme based on laser synchronization induced by a common wireless random signal. Two semiconductor lasers are synchronized under injection of the drive signal after electrical-optical conversion and emit irregular outputs that are used to generate shared keys. Our proof-of-concept experiment using a complex drive signal achieved a secure key generation rate of up to 150 Mbit/s with a bit error rate below 3.

Physical-layer key distribution based on commonly-driven laser synchronization with random modulation of drive light.

We propose and experimentally demonstrate a physical-layer key distribution scheme using commonly-driven laser synchronization with random modulation of drive light. Two parameter-matched semiconductor lasers injected by a common complex drive light are used as entropy sources for legitimate users. Legitimate users generate their own random signal by randomly time-division multiplexing of two random sequences with a certain duration according to individual control codes, and then independently modulate the drive light.

Security optimization of synchronization in DFB lasers under constant-amplitude random-phase drive light by reducing drive-response correlation.

Common-signal-induced laser synchronization promoted a promising paradigm of high-speed physical key distribution. Constant-amplitude and random-phase (CARP) light was proposed as the common drive signal to enhance security by reducing the correlation between the drive and the laser response in intensity. However, the correlation in light phase is not examined.

Successful leadless pacemaker implantation in a patient with dextroversion of the heart: A case report.

Background: Dextroversion is defined as the presence of dextrocardia with situs solitus, dextro-loop ventricles, and normally related great arteries. Dextrocardia can pose technical challenges when interventional treatments are required. However, the challenges posed by dextroversion can be amplified due to the disruption of typical anatomical relationships, the unpredictable positioning and boundaries of cardiac structures resulting from the shift, and the pathological processes influencing rotation.

Chaos synchronization of VCSELs with common injection of polarization-random light.

We propose and numerically demonstrate chaos synchronization of two vertical-cavity surface-emitting lasers (VCSELs) induced by common injection of constant-amplitude random-polarization light for physical key distribution. Results show that synchronization is sensitive to polarization rotation of injection light, and synchronization coefficients larger than 0.9 can be achieved as the rotation-degree mismatch is smaller than ±10°.

Millimeter-wave noise generation based on a monolithically integrated dual-mode chaotic laser.

A millimeter-wave noise generation scheme is proposed in this paper. The scheme is based on a monolithically integrated dual-mode chaotic laser, which consists of a distributed Bragg feedback (DFB) section, a phase section, and an optical amplification section. The output spectrum state of the dual-mode laser can be controlled by adjusting the injection current in the three regions.

Wideband chaos synchronization using discrete-mode semiconductor lasers.

Optical chaos communication encounters difficulty in high-speed transmission due to the challenge of realizing wideband chaos synchronization. Here, we experimentally demonstrate a wideband chaos synchronization using discrete-mode semiconductor lasers (DMLs) in a master-slave open-loop configuration. The DML can generate wideband chaos with a 10-dB bandwidth of 30 GHz under simple external mirror feedback.

High-entropy-rate broadband chaos generation by using short-resonant-cavity DFB semiconductor laser with optical feedback.

Semiconductor lasers with delayed optical feedback are a promising source of optical chaos for practical applications, owing to simple configurations that are easy to integrate and synchronize. However, for traditional semiconductor lasers, the chaos bandwidth is limited by the relaxation frequency to several gigahertz. Here, we propose and experimentally demonstrate that a short-resonant-cavity distributed-feedback (SC-DFB) laser can generate broadband chaos only with simple feedback from an external mirror.

Performance improvement of coherent optical chaos communication using probabilistic shaping.

We numerically investigate the effects of probabilistic shaping on the performance improvement of coherent optical chaos communication. Results show that the decryption bit-error ratio (BER) of the 16-ary quadrature amplitude modulation (QAM) signal decreases upon increasing the probabilistic shaping factor. It is predicted that the BER of 10-GBd 16QAM can be decreased by one order of magnitude.

56 Gb/s PAM4 physical secure communication based on electro-optic self-feedback hardware temporal phase encryption and decryption.

To guarantee information security from the lowest level of optical networks, it is essential to provide physical layer security in fiber-optic communication systems. However, it is challenging to realize high speed physical secure optical communication based on advanced optical modulation formats and pure commercial hardware components. In this work, we report an experimental demonstration of a high-speed 56 Gb/s PAM4 physical-layer secure optical communication system by employing an electro-optic self-feedback hardware module for temporal self-phase encryption and decryption without consuming any additional encryption channel.

Multiple plasmon-induced transparency based on black phosphorus and graphene for high-sensitivity refractive index sensing.

A hybrid bilayer black phosphorus (BP) and graphene structure with high sensitivity is proposed for obtaining plasmon-induced transparency (PIT). By means of surface plasmon resonance in the rectangular-ring BP structure and ribbon graphene structure, a PIT effect with high refractive index sensitivity is achieved, and the surface plasmon hybridization between graphene and anisotropic BP is analyzed theoretically. Meanwhile, the PIT effect is quantitatively described using the coupled oscillator model and the strong coherent coupling phenomena are analyzed by adjusting the coupling distance between BP and graphene, the Fermi level of graphene, and the crystal orientation of BP, respectively.

Ring-core few-mode fiber and DPP-BOTDA-based distributed large-curvature sensing eligible for shape reconstruction.

This study proposes a distributed large-curvature sensor based on ring-core few-mode fiber (RC-FMF) and differential pulse-pair Brillouin optical time-domain analysis (DPP-BOTDA). The RC-FMF is adhered to a thin steel substrate and an asymmetric hump shape is reconstructed using the Frenet-Serret algorithm. The proposed curvature sensor demonstrates a larger curvature-sensing range, excellent tolerance to bending-induced optical loss, and increased Brillouin gain coefficient.

Muse cells decrease the neuroinflammatory response by modulating the proportion of M1 and M2 microglia .

Neuroinflammation hinders repair of the central nervous system (CNS). Stem cell transplantation is a very promising approach for treatment of CNS injuries. However, it is difficult to select seed cells that can both facilitate nerve regeneration and improve the microenvironment in the CNS.

Fast physical random bit generation using a millimeter-wave white noise source.

A broadband millimeter-wave (MMW) white noise signal generated by optical heterodyning of two Fabry-Perot laser diodes (FP-LDs) subject to optical feedback is demonstrated and employed for fast physical random bit generation with a simple least significant bits (LSBs) retaining method. Firstly, under suitable feedback conditions, two external-cavity feedback FP-LDs can be easily driven into chaotic states. In this process, the optical spectra of multi-longitudinal modes are significantly broadened.

Broadband and flat millimeter-wave noise source based on the heterodyne of two Fabry-Perot lasers.

We demonstrate a broadband and flat millimeter-wave (MMW) noise source based on the heterodyne of two Fabry-Perot lasers subject to optical feedback. Different mode intervals between two lasers are designed to generate beat terms at specific frequencies. As a proof-of-concept demonstration, a MMW noise signal with a 3-dB bandwidth of 50 GHz (limited by the measurement bandwidth) and flatness of less than 2.

Deep insight on mechanism and contribution of As(V) removal by thermal modification waste concrete powder.

Expanding the utilization strategy of waste concrete powder (WCP) is conducive to minimizing the environmental burden caused by construction & demolition wastes (C&DW). In this study, WCP prepared in the laboratory was thermally treated and used to remove As(V) from wastewater. Batch adsorption tests were implemented to explore the influence factors such as modification temperature (0-850 °C), pH (1.

Increased plasma sestrin2 concentrations in patients with chronic heart failure and predicted the occurrence of major adverse cardiac events: A 36-month follow-up cohort study.

Background: Previous study had demonstrated that sestrin2 (Sesn2) expression was increased in human failing heart. Although, the circulating Sesn2 concentrations in patients with chronic heart failure (CHF) remains unknown. This study investigated plasma Sesn2 concentrations in patients with CHF and the role between Sesn2 and the occurrence of major adverse cardiac events.

Development of a loop-mediated isothermal amplification method for rapid detection of caprine arthritis-encephalitis virus proviral DNA.

A rapid detection assay based on loop-mediated isothermal amplification (LAMP) has been developed for detecting caprine arthritis-encephalitis (CAEV) proviral DNA. The LAMP assay utilized a set of five primers designed against highly conserved sequences located within the p25 gene region. The assay successfully detected CAEV proviral DNA in total DNA extracts originating from cell culture, whole blood samples and separated PBMCs.

Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu.

The HIV-1 Vpu protein is required for efficient viral release from human cells. For HIV-2, the envelope (Env) protein replaces the role of Vpu. Both Vpu and HIV-2 Env enhance virus release by counteracting an innate host-cell block within human cells that is absent in African green monkey (AGM) cells.